Search Results - "Silva, Patrícia A"

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research by Pinto, Bárbara, Henriques, Ana C, Silva, Patrícia M A, Bousbaa, Hassan

“…Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing…”
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An RNA Pseudoknot Is Required for Production of Yellow Fever Virus Subgenomic RNA by the Host Nuclease XRN1 by SILVA, Patricia A. G. C, PEREIRA, Carina F, DALEBOUT, Tim J, SPAAN, Willy J. M, BREDENBEEK, Peter J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity by Moreira, Joana, Silva, Patrícia M A, Castro, Eliseba, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…Recently, the diarylpentanoid ( ) has been identified as a potent in vitro growth inhibitor of cancer cells, with a GI value between 0.17 and 0.45 µM, showing…”
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Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic by Henriques, Ana C., Silva, Patrícia M. A., Sarmento, Bruno, Bousbaa, Hassan

“…Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated…”
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Second-Generation Antimitotics in Cancer Clinical Trials by Novais, Pedro, Silva, Patrícia M. A., Amorim, Isabel, Bousbaa, Hassan

“…Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics, mainly microtubule-targeting agents (MTAs), such as taxanes…”
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Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance by Cunha, Andrea, Silva, Patrícia M. A, Sarmento, Bruno, Queirós, Odília

“…The “Warburg effect” consists of a metabolic shift in energy production from oxidative phosphorylation to glycolysis. The continuous activation of glycolysis…”
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Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids by Barbosa, Flávia, Araújo, Joana, Gonçalves, Virgínia M F, Palmeira, Andreia, Cunha, Andrea, Silva, Patrícia M A, Fernandes, Carla, Pinto, Madalena, Bousbaa, Hassan, Queirós, Odília, Tiritan, Maria Elizabeth

“…Cancer is a complex disease characterized by several alterations, which confer, to the cells, the capacity to proliferate uncontrollably and to resist cellular…”
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Translational control of UIS4 protein of the host-parasite interface is mediated by the RNA binding protein Puf2 in Plasmodium berghei sporozoites by Silva, Patrícia A. G. C., dos Santos Guerreiro, Ana Maria, Santos, Jorge, Braks, Joanna A. M., Janse, Chris J., Mair, Gunnar

“…Copyright: © 2016 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits…”
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Combination Therapy as a Promising Way to Fight Oral Cancer by Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis and high mortality rates. Conventional treatment strategies, such…”
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BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity by Novais, Pedro, Silva, Patrícia M A, Moreira, Joana, Palmeira, Andreia, Amorim, Isabel, Pinto, Madalena, Cidade, Honorina, Bousbaa, Hassan

“…Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular…”
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Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer by Calheiros-Lobo, Mafalda, Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in incidence, with oral squamous cell carcinoma (OSCC) as the predominant…”
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Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure-Activity Relationship Studies by Moreira, Joana, Silva, Patrícia M A, Barros, Matilde, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid ( ) based on the combination of subunits of two promising antiproliferative…”
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Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction by Pinto, Bárbara, Silva, João P N, Silva, Patrícia M A, Barbosa, Daniel José, Sarmento, Bruno, Tavares, Juliana Carvalho, Bousbaa, Hassan

“…Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives…”
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Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein by Nunes, Mariana, Silva, Patrícia M A, Coelho, Ricardo, Pinto, Carla, Resende, Albina, Bousbaa, Hassan, Almeida, Gabriela M, Ricardo, Sara

“…Debulking surgery followed by chemotherapy are the standard of care for high-grade serous carcinoma. After an initial good response to treatment, the majority…”
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Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing by Silva, João P N, Pinto, Bárbara, Monteiro, Luís, Silva, Patrícia M A, Bousbaa, Hassan

“…Many proteins regulating mitosis have emerged as targets for cancer therapy, including the kinesin spindle protein (KSP) and Aurora kinase B (AurB). KSP is…”
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New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation by Moreira, Joana, Ribeiro, Diana, Silva, Patrícia M A, Nazareth, Nair, Monteiro, Madalena, Palmeira, Andreia, Saraiva, Lucília, Pinto, Madalena, Bousbaa, Hassan, Cidade, Honorina

“…The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the…”
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Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity by Durães, Fernando, Silva, Patrícia M. A., Novais, Pedro, Amorim, Isabel, Gales, Luís, Esteves, Cátia I. C., Guieu, Samuel, Bousbaa, Hassan, Pinto, Madalena, Sousa, Emília

“…Thioxanthones are bioisosteres of the naturally occurring xanthones. They have been described for multiple activities, including antitumor. As such, the…”
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Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel by Fonseca, Joana, Marques, Sandra, Silva, Patrícia M A, Brandão, Pedro, Cidade, Honorina, Pinto, Madalena M, Bousbaa, Hassan

“…We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (1), induced cytotoxicity…”
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A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel by França, Fábio, Silva, Patrícia M A, Soares, José X, Henriques, Ana C, Loureiro, Daniela R P, Azevedo, Carlos M G, Afonso, Carlos M M, Bousbaa, Hassan

“…Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a…”
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High CDC20 expression is associated with poor prognosis in oral squamous cell carcinoma by Moura, Inês M. B., Delgado, Maria L., Silva, Patrícia M. A., Lopes, Carlos A., do Amaral, José B., Monteiro, Luís S., Bousbaa, Hassan

“…Objectives Human Cell Division Cycle 20 (CDC20) homolog is a crucial target of the spindle assembly checkpoint. It is an activator of the Anaphase‐Promoting…”
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