Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate

To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatt...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 7; p. e102876
Main Authors:	Furriel, Angélica, Campos-Silva, Pamella, Silva, Paola Cariello Guedes Picarote, Costa, Waldemar Silva, Sampaio, Francisco José Barcellos, Gregório, Bianca Martins
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16-07-2014 Public Library of Science (PLoS)
Subjects:	Acid resistance Analysis of Variance Angiogenesis Animals Antigens Biology and Life Sciences Body fat Body mass Body weight Body Weight - drug effects Body Weights and Measures Carbohydrate metabolism Carbohydrate Metabolism - drug effects Carbohydrates Cell proliferation Cellular structure Cholesterol Density Diabetes Diet Diet, High-Fat Dietary Fats - pharmacology Enzymes Epithelial cells Epithelium Fatty acids Fatty Acids - pharmacology Fibroblasts Glucose Growth factors High fat diet Immunohistochemistry Insulin Insulin resistance Insulin Resistance - physiology Lipids Male Medicine and Health Sciences Metabolism Morphology Muscles Nutrition research Obesity Overweight Physiological aspects Polyunsaturated fatty acids Prostate Prostate - anatomy & histology Prostate - drug effects Prostate - metabolism Prostate cancer Proteins Rats Rats, Wistar Research and Analysis Methods Risk analysis Risk factors Rodents Saturated fatty acids Serum levels Smooth muscle Unsaturated fatty acids Brazil Rio de Janeiro Brazil
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Summary:	To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure. Groups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group. Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: BMG. Performed the experiments: AF PCS PCGPS. Analyzed the data: BMG WSC FJBS. Contributed reagents/materials/analysis tools: WSC FJBS. Wrote the paper: AF BMG. Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0102876