Search Results - "Silva, Odete A B da Cruz E"
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Exosome isolation from distinct biofluids using precipitation and column-based approaches
Published in PloS one (11-06-2018)“…The potential of exosomes as biomarker resources for diagnostics, prognostics and even for therapeutics is an area of intense research. Despite the various…”
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2
Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease
Published in International journal of molecular sciences (01-02-2024)“…Phosphorylation plays a key role in Alzheimer's disease (AD) pathogenesis, impacting distinct processes such as amyloid-beta (Aβ) peptide production and tau…”
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3
Exosomal Aβ-Binding Proteins Identified by "In Silico" Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease
Published in International journal of molecular sciences (11-04-2021)“…The potential of exosomes as biomarker resources for diagnostics and even for therapeutics has intensified research in the field, including in the context of…”
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4
Nuclear Envelope Alterations in Myotonic Dystrophy Type 1 Patient-Derived Fibroblasts
Published in International journal of molecular sciences (04-01-2022)“…Myotonic dystrophy type 1 (DM1) is a hereditary and multisystemic disease characterized by myotonia, progressive distal muscle weakness and atrophy. The…”
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5
Nuclear envelope dysfunction and its contribution to the aging process
Published in Aging cell (01-05-2020)“…The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface…”
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Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease
Published in Proteomics (Weinheim) (01-08-2023)“…Aging is the main risk factor for the appearance of age‐related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common form of…”
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7
Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility
Published in Biological reviews of the Cambridge Philosophical Society (01-08-2019)“…ABSTRACT The production of highly specialized spermatozoa from undifferentiated spermatogonia is a strictly organized and programmed process requiring…”
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8
Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease
Published in ACS chemical neuroscience (19-02-2014)“…Alzheimer’s disease is characterized by pathological aggregation of protein tau and amyloid-β peptides, both of which are considered to be toxic to neurons…”
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APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis
Published in Molecular neurobiology (01-02-2021)“…The amyloid precursor protein (APP) is a transmembrane glycoprotein central to Alzheimer’s disease (AD) with functions in brain development and plasticity,…”
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10
Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes
Published in BMC evolutionary biology (06-11-2013)“…Pseudogenes are traditionally considered "dead" genes, therefore lacking biological functions. This view has however been challenged during the last decade…”
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Fourier-Transform Infrared Spectroscopy as a Discriminatory Tool for Myotonic Dystrophy Type 1 Metabolism: A Pilot Study
Published in International journal of environmental research and public health (06-04-2021)“…Myotonic dystrophy type 1 (DM1) is a hereditary disease characterized by progressive distal muscle weakness and myotonia. Patients with DM1 have abnormal lipid…”
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12
Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems
Published in Scientific reports (21-03-2019)“…Cosurface electrode architectures are able to deliver personalized electric stimuli to target tissues. As such, this technology holds potential for a variety…”
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13
An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model
Published in PloS one (10-10-2013)“…T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the…”
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14
Editorial: Digital health and neuroscience: Recent history, current trends, and future developments
Published in Frontiers in integrative neuroscience (14-11-2022)“…According to the Food and Drug Administration (FDA)1, digital health is composed of the subfields of mobile health, health information technology, wearable…”
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15
Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease
Published in Journal of neurochemistry (01-01-2021)“…Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel…”
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Identification and characterization of the BRI2 interactome in the brain
Published in Scientific reports (23-02-2018)“…BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include…”
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Nuclear Accumulation of LAP1:TRF2 Complex during DNA Damage Response Uncovers a Novel Role for LAP1
Published in Cells (Basel, Switzerland) (29-07-2020)“…Lamina-associated polypeptide 1 (LAP1) is a nuclear envelope (NE) protein whose function remains poorly characterized. In a recent LAP1 protein interactome…”
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NMR metabolomics to study the metabolic response of human osteoblasts to non‐poled and poled poly (L‐lactic) acid
Published in Magnetic resonance in chemistry (01-11-2019)“…Untargeted nuclear magnetic resonance (NMR) metabolomics was employed, for the first time to our knowledge, to characterize the metabolome of human osteoblast…”
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19
Protein phosphatase 1 and its complexes in carcinogenesis
Published in Current cancer drug targets (01-01-2014)“…Understanding the molecular mechanisms and the signaling pathways that underlie the pathology of cancer progression is crucial for the development of novel…”
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Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform
Published in Journal of neurochemistry (01-12-2011)“…J. Neurochem. (2011) 119, 1086–1098. Fe65 is a multimodular adaptor protein that interacts with the cytosolic domain of the β‐amyloid precursor protein (APP),…”
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