Search Results - "Silva, Mauro S B"

New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development by Silva, Mauro S. B., Giacobini, Paolo

“…Research into the physiological actions of anti-Müllerian hormone (AMH) has rapidly expanded from its classical role in male sexual differentiation to the…”
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GnRH replacement rescues cognition in Down syndrome by Manfredi-Lozano, Maria, Leysen, Valerie, Adamo, Michela, Paiva, Isabel, Rovera, Renaud, Pignat, Jean-Michel, Timzoura, Fatima Ezzahra, Candlish, Michael, Eddarkaoui, Sabiha, Malone, Samuel A, Silva, Mauro S B, Trova, Sara, Imbernon, Monica, Decoster, Laurine, Cotellessa, Ludovica, Tena-Sempere, Manuel, Claret, Marc, Paoloni-Giacobino, Ariane, Plassard, Damien, Paccou, Emmanuelle, Vionnet, Nathalie, Acierno, James, Maceski, Aleksandra Maleska, Lutti, Antoine, Pfrieger, Frank, Rasika, S, Santoni, Federico, Boehm, Ulrich, Ciofi, Philippe, Buée, Luc, Haddjeri, Nasser, Boutillier, Anne-Laurence, Kuhle, Jens, Messina, Andrea, Draganski, Bogdan, Giacobini, Paolo, Pitteloud, Nelly, Prevot, Vincent

“…At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these…”
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A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice by Decoster, Laurine, Trova, Sara, Zucca, Stefano, Bulk, Janice, Gouveia, Ayden, Ternier, Gaetan, Lhomme, Tori, Legrand, Amandine, Gallet, Sarah, Boehm, Ulrich, Wyatt, Amanda, Wahl, Vanessa, Wartenberg, Philipp, Hrabovszky, Erik, Rácz, Gergely, Luzzati, Federico, Nato, Giulia, Fogli, Marco, Peretto, Paolo, Schriever, Sonja C., Bernecker, Miriam, Pfluger, Paul T., Steculorum, Sophie M., Bovetti, Serena, Rasika, Sowmyalakshmi, Prevot, Vincent, Silva, Mauro S. B., Giacobini, Paolo

“…Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive…”
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Editorial: The neuroendocrine female brain: from normal reproductive function to disease by Silva, Mauro S B, Navarro, Victor M, Chachlaki, Konstantina

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Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice by Nair, Betina B., Khant Aung, Zin, Porteous, Robert, Prescott, Melanie, Glendining, Kelly A., Jenkins, Danielle E., Augustine, Rachael A., Silva, Mauro S.B., Yip, Siew H., Bouwer, Gregory T., Brown, Colin H., Jasoni, Christine L., Campbell, Rebecca E., Bunn, Stephen J., Anderson, Greg M., Grattan, David R., Herbison, Allan E., Iremonger, Karl J.

“…Chronic stress exerts multiple negative effects on the physiology and health of an individual. In the present study, we examined hypothalamic, pituitary and…”
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Don't Trust Your Gut: When Gut Microbiota Disrupt Fertility by Silva, Mauro S B, Giacobini, Paolo

“…Emerging evidence indicates that the composition of the gut microbiome might affect metabolic homeostasis as well as reproductive fitness in women. In Nature…”
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The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release by Delli, Virginia, Silva, Mauro S.B., Prévot, Vincent, Chachlaki, Konstantina

“…Gonadotropin-releasing hormone (GnRH) is the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, and therefore of fertility and reproduction…”
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Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway by Silva, Mauro S. B., Decoster, Laurine, Trova, Sara, Mimouni, Nour E.H., Delli, Virginia, Chachlaki, Konstantina, Yu, Qiang, Boehm, Ulrich, Prevot, Vincent, Giacobini, Paolo

“…Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and sexual satisfaction. While the hypothalamus is known to…”
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Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism by Fernandois, Daniela, Rusidzé, Mariam, Mueller-Fielitz, Helge, Sauve, Florent, Deligia, Eleonora, Silva, Mauro S.B., Evrard, Florence, Franco-García, Aurelio, Mazur, Daniele, Martinez-Corral, Ines, Jouy, Nathalie, Rasika, S., Maurage, Claude-Alain, Giacobini, Paolo, Nogueiras, Ruben, Dehouck, Benedicte, Schwaninger, Markus, Lenfant, Francoise, Prevot, Vincent

“…Estrogen secretion by the ovaries regulates the hypothalamic-pituitary-gonadal axis during the reproductive cycle, influencing gonadotropin-releasing hormone…”
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Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome by Silva, Mauro S.B., Desroziers, Elodie, Hessler, Sabine, Prescott, Melanie, Coyle, Chris, Herbison, Allan E., Campbell, Rebecca E.

“…Enhanced GABA activity in the brain and a hyperactive hypothalamic-pituitary-gonadal axis are associated with polycystic ovary syndrome (PCOS), the most common…”
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Overactivation of GnRH neurons is sufficient to trigger polycystic ovary syndrome-like traits in female mice by Silva, Mauro S.B., Decoster, Laurine, Delpouve, Gaspard, Lhomme, Tori, Ternier, Gaetan, Prevot, Vincent, Giacobini, Paolo

“…Polycystic ovary syndrome (PCOS) is the most common endocrine disorder leading to anovulatory infertility. Abnormalities in the central neuroendocrine system…”
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Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome by Barbotin, Anne-Laure, Mimouni, Nour El Houda, Kuchcinski, Grégory, Lopes, Renaud, Viard, Romain, Rasika, Sowmyalakshmi, Mazur, Daniele, Silva, Mauro S.B., Simon, Virginie, Boursier, Angèle, Pruvo, Jean-Pierre, Yu, Qiang, Candlish, Michael, Boehm, Ulrich, Bello, Federica Dal, Medana, Claudio, Pigny, Pascal, Dewailly, Didier, Prevot, Vincent, Catteau-Jonard, Sophie, Giacobini, Paolo

“…Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder affecting between 5 and 18% of women worldwide. An elevated frequency of…”
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Polycystic Ovary Syndrome and the Neuroendocrine Consequences of Androgen Excess by Silva, Mauro S B, Campbell, Rebecca E

“…Polycystic ovary syndrome (PCOS) is a major endocrine disorder strongly associated with androgen excess and frequently leading to female infertility. Although…”
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7996 Neuroanatomic Characterization of Mouse Kisspeptin Neurons in the Bed Nucleus of the Stria Terminalis by Zdon, Samuel Thomas, Silva, Mauro S B, Navarro, Victor Manuel

“…Abstract Disclosure: S.T. Zdon: None. M.S. Silva: None. V.M. Navarro: None. Kisspeptin (Kiss1) neurons are essential for reproductive function as they are…”
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Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS by Silva, Mauro Sb, Prescott, Melanie, Campbell, Rebecca E

“…Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical…”
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OR17-06 Clinical And Mechanistic Insight For The Therapeutic Potential Of Intranasal Kisspeptin Administration To Treat Reproductive Disorders In Humans by Mills, Edouard G, Swedrowska, Magda, Delli, Virginia, Chachlaki, Konstantina, Silva, Mauro S B, Decoster, Laurine, Ternier, Gaetan, Thurston, Layla, Phylactou, Maria, Patel, Bijal, Yang, Lisa, Clarke, Sophie A, Muzi, Beatrice, Alexander, Emma C, Choudhury, Muhammad, Bech, Paul, Abbara, Ali, Forbes, Ben, Giacobini, Paolo, Prevot, Vincent, Comninos, Alexander N, Dhillo, Waljit S

“…Abstract Disclosure: E.G. Mills: None. M. Swedrowska: None. V. Delli: None. K. Chachlaki: None. M. Silva: None. L. Decoster: None. G. Ternier: None. L…”
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