Search Results - "Silva, Manuel T"

Secondary necrosis: The natural outcome of the complete apoptotic program by Silva, Manuel T.

“…The predominant definition of apoptosis considers that the elimination of the apoptosing cell is by heterolytic degradation following phagocytosis by an…”
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When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system by Silva, Manuel T.

“…The presence of two dedicated phagocytic cells working cooperatively represents an advantageous innate immune strategy that allows the efficient and safe…”
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Macrophage phagocytosis of neutrophils at inflammatory/infectious foci: a cooperative mechanism in the control of infection and infectious inflammation by Silva, Manuel T.

“…Review discusses macrophage phagocytosis of neutrophils in the protective response to infection as a cooperative mechanism which combines pro‐antimicrobial and…”
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Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens by Silva, Manuel T.

“…Neutrophils and macrophages cooperate as inducers and effectors of adaptive immune responses to infection by microbial extracellular and intracellular…”
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Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism by Silva, Manuel T.

“…Review discusses bacterial mechanism promoting immune evasion and release of tissue‐damaging phagocyte molecules by induction of macrophage and neutrophil…”
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Neutrophils and macrophages: the main partners of phagocyte cell systems by Silva, Manuel T, Correia-Neves, Margarida

“…Biological cellular systems are groups of cells sharing a set of characteristics, mainly key function and origin. Phagocytes are crucial in the host defense…”
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Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer by Silva, Manuel T, MD, Portaels, Françoise, Prof, Pedrosa, Jorge, Prof

“…Summary The necrotising skin infection Buruli ulcer is at present the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. Buruli…”
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Buruli ulcer by Portaels, Françoise, PhD, Silva, Manuel T., MD, PhD, Meyers, Wayne M., MD, PhD

“…Abstract Buruli ulcer is an indolent necrotizing disease of the skin, subcutaneous tissue, and bone that is caused by Mycobacterium ulcerans . Buruli ulcer is…”
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First cultivation and characterization of Mycobacterium ulcerans from the environment by Portaels, Françoise, Meyers, Wayne M, Ablordey, Anthony, Castro, António G, Chemlal, Karim, de Rijk, Pim, Elsen, Pierre, Fissette, Krista, Fraga, Alexandra G, Lee, Richard, Mahrous, Engy, Small, Pamela L C, Stragier, Pieter, Torrado, Egídio, Van Aerde, Anita, Silva, Manuel T, Pedrosa, Jorge

“…Mycobacterium ulcerans disease, or Buruli ulcer (BU), is an indolent, necrotizing infection of skin, subcutaneous tissue and, occasionally, bones. It is the…”
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Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen by Gama, José B, Ohlmeier, Steffen, Martins, Teresa G, Fraga, Alexandra G, Sampaio-Marques, Belém, Carvalho, Maria A, Proença, Fernanda, Silva, Manuel T, Pedrosa, Jorge, Ludovico, Paula

“…Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The tissue damage characteristic of BU lesions is known to be driven by the…”
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Hyperosmotic stress induces metacaspase‐ and mitochondria‐dependent apoptosis in Saccharomyces cerevisiae by Silva, Rui D., Sotoca, Roberto, Johansson, Björn, Ludovico, Paula, Sansonetty, Filipe, Silva, Manuel T., Peinado, José M., Côrte‐Real, Manuela

“…Summary During the last years, several reports described an apoptosis‐like programmed cell death process in yeast in response to different environmental…”
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Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination by Fraga, Alexandra G, Martins, Teresa G, Torrado, Egídio, Huygen, Kris, Portaels, Françoise, Silva, Manuel T, Castro, António G, Pedrosa, Jorge

“…Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcerans that can result in extensive necrotizing cutaneous lesions due to the…”
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Amoebae as potential environmental hosts for Mycobacterium ulcerans and other mycobacteria, but doubtful actors in Buruli ulcer epidemiology by Gryseels, Sophie, Amissah, Diana, Durnez, Lies, Vandelannoote, Koen, Leirs, Herwig, De Jonckheere, Johan, Silva, Manuel T, Portaels, Françoise, Ablordey, Anthony, Eddyani, Miriam

“…The reservoir and mode of transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer, remain unknown. Ecological, genetic and epidemiological…”
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Evidence for an Intramacrophage Growth Phase of Mycobacterium ulcerans by Torrado, Egídio, Fraga, Alexandra G, Castro, António G, Stragier, Pieter, Meyers, Wayne M, Portaels, Françoise, Silva, Manuel T, Pedrosa, Jorge

“…Mycobacterium ulcerans is the etiologic agent of Buruli ulcer (BU), an emerging tropical skin disease. Virulent M. ulcerans secretes mycolactone, a cytotoxic…”
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Mycobacterium ulcerans Triggers T-Cell Immunity followed by Local and Regional but Not Systemic Immunosuppression by Fraga, Alexandra G, Cruz, Andrea, Martins, Teresa G, Torrado, Egídio, Saraiva, Margarida, Pereira, Daniela R, Meyers, Wayne M, Portaels, Françoise, Silva, Manuel T, Castro, António G, Pedrosa, Jorge

“…Buruli ulcer is a neglected infectious disease caused by Mycobacterium ulcerans and is characterized by necrotic cutaneous lesions induced by the exotoxin…”
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Local and regional re-establishment of cellular immunity during curative antibiotherapy of murine Mycobacterium ulcerans infection by Martins, Teresa G, Gama, José B, Fraga, Alexandra G, Saraiva, Margarida, Silva, Manuel T, Castro, António G, Pedrosa, Jorge

“…Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated…”
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Aquatic insects and Mycobacterium ulcerans: an association relevant to Buruli ulcer control? by Silva, Manuel T, Portaels, Françoise, Pedrosa, Jorge

“…Texeira and colleagues discuss the association between arthropods and M. ulcerans in the light of a new study in PLoS Medicine …”
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Infection with Mycobacterium ulcerans Induces Persistent Inflammatory Responses in Mice by Oliveira, Martinha S, Fraga, Alexandra G, Torrado, Egídio, Castro, António G, Pereira, João P, Longatto Filho, Adhemar, Milanezi, Fernanda, Schmitt, Fernando C, Meyers, Wayne M, Portaels, Françoise, Silva, Manuel T, Pedrosa, Jorge

“…Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses,…”
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Classical labeling of bacterial pathogens according to their lifestyle in the host: inconsistencies and alternatives by Silva, Manuel T

“…An ample understanding of the complex interactions between host and pathogen will improve our ability to develop new prophylactic and therapeutic measures…”
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Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infection by Martins, Teresa G, Trigo, Gabriela, Fraga, Alexandra G, Gama, José B, Longatto-Filho, Adhemar, Saraiva, Margarida, Silva, Manuel T, Castro, António G, Pedrosa, Jorge

“…Buruli ulcer (BU) is a necrotizing disease of the skin, subcutaneous tissue and bone caused by Mycobacterium ulcerans. It has been suggested that the immune…”
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