Search Results - "Silva, Luciana Madeira da"

Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity by Silva, Luciana Madeira da, Beverley, Stephen M., Miller, Louis H.

“…Target of rapamycin (TOR) kinases are key regulators of cell growth, proliferation, and structure in eukaryotes, processes that are highly coordinated during…”
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Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins by Madeira da Silva, Luciana, Owens, Katherine L, Murta, Silvane M.F, Beverley, Stephen M

“…Surface glycoconjugates play important roles in the infectious cycle of Leishmania major, including the abundant lipophosphoglycan (LPG) implicated in parasite…”
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Interplay between Immune Checkpoint Proteins and Cellular Metabolism by Lim, Sangbin, Phillips, Joshua B, Madeira da Silva, Luciana, Zhou, Ming, Fodstad, Oystein, Owen, Laurie B, Tan, Ming

“…With the recent successes in immuno-oncology, renewed interest in the role of immune checkpoint modulators, such as the B7 family proteins, has escalated. The…”
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ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling by Meng, Erhong, Mitra, Aparna, Tripathi, Kaushlendra, Finan, Michael A, Scalici, Jennifer, McClellan, Steve, Madeira da Silva, Luciana, Reed, Eddie, Shevde, Lalita A, Palle, Komaraiah, Rocconi, Rodney P

“…Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem…”
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Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer by Miree, Orlandric, Srivastava, Sanjeev Kumar, Khan, Mohammad Aslam, Sameeta, Fnu, Acharya, Srijan, Ndetan, Harrison, Singh, Karan Pal, Hertweck, Kate Louise, Dasgupta, Santanu, da Silva, Luciana Madeira, Rocconi, Rodney Paul, Carter, James Elliot, Singh, Seema, Singh, Ajay Pratap

“…Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning result in dismal survival of ovarian cancer (OC) patients. Therefore,…”
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Associations between DNA Damage and PD-L1 Expression in Ovarian Cancer, a Potential Biomarker for Clinical Response by Mann, Elise K, Lee, Kevin J, Chen, Dongquan, da Silva, Luciana Madeira, Dal Zotto, Valeria L, Scalici, Jennifer, Gassman, Natalie R

“…Programmed death ligand-1 (PD-L1) inhibitors are currently under investigation as a potential treatment option for ovarian cancer. Although this therapy has…”
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The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing by Diaz-Gonzalez, Rosario, Kuhlmann, F Matthew, Galan-Rodriguez, Cristina, Madeira da Silva, Luciana, Saldivia, Manuel, Karver, Caitlin E, Rodriguez, Ana, Beverley, Stephen M, Navarro, Miguel, Pollastri, Michael P

“…Target repurposing utilizes knowledge of "druggable" targets obtained in one organism and exploits this information to pursue new potential drug targets in…”
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ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer by Rocconi, Rodney P., Stanbery, Laura, Tang, Min, Madeira da Silva, Luciana, Walter, Adam, Monk, Bradley J., Herzog, Thomas J., Coleman, Robert L., Manning, Luisa, Wallraven, Gladice, Horvath, Staci, Bognar, Ernest, Senzer, Neil, Brun, Scott, Nemunaitis, John

“…Background Broadened use of predictive molecular and phenotypic profiling amongst oncologists has facilitated optimal integration of targeted- and…”
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Optimization of acid hydrolysis of sugarcane bagasse and investigations on its fermentability for the production of xylitol by Candida guilliermondii by Fogel, R, Garcia, R.R, Oliveira, R. da S, Palacio, D.N.M, Madeira, L. da S, Pereira, N. Jr

“…The dilute-acid hydrolysis of sugarcane bagasse was optimized using a statistical experimental design resulting in hydrolysates containing 57.25 g/L of xylose,…”
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Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α by Lim, Sangbin, Liu, Hao, Madeira da Silva, Luciana, Arora, Ritu, Liu, Zixing, Phillips, Joshua B, Schmitt, David C, Vu, Tung, McClellan, Steven, Lin, Yifeng, Lin, Wensheng, Piazza, Gary A, Fodstad, Oystein, Tan, Ming

“…B7-H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. While B7-H3 overexpression is associated with poor…”
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Analysis of the COVID-19 Vaccine Development Process: an Exploratory Study of Accelerating Factors and Innovative Environments by Defendi, Hugo Garcia Tonioli, da Silva Madeira, Luciana, Borschiver, Suzana

“…Purpose The pace of the COVID-19 vaccine development process is unprecedented and is challenging the traditional paradigm of vaccinology science. The main…”
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Prospects and Trends in the Brazilian Market for Biologically Sourced Products by da Silva Madeira, Luciana, Borschiver, Suzana, Pereira Jr, Nei

“…The aim of this paper was to select the most interesting Brazilian biopharmaceuticals, with the best market opportunity for production. The biopharmaceuticals…”
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Unraveling the etiology of ovarian cancer racial disparity in the deep south: Is it nature or nurture? by Ross, Jerlinda, Braswell, Katelyn V, da Silva, Luciana Madeira, Mujica, Frances, Stutsman, Sam, Finan, Michael A, Nicolson, William, Harmon, Mary Danner, Missanelli, Megan, Cohen, Alex, Singh, Ajay, Scalici, Jennifer M, Rocconi, Rodney P

“…Abstract Background Our objective was to evaluate racial treatment and survival disparities in black women with ovarian cancer in the Deep South and to…”
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Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling by Zhu, Bing, Lindsey, Ashley, Li, Nan, Lee, Kevin, Ramirez-Alcantara, Veronica, Canzoneri, Joshua C, Fajardo, Alexandra, Madeira da Silva, Luciana, Thomas, Meagan, Piazza, John T, Yet, Larry, Eberhardt, Brian T, Gurpinar, Evrim, Otali, Dennis, Grizzle, William, Valiyaveettil, Jacob, Chen, Xi, Keeton, Adam B, Piazza, Gary A

“…Phosphodiesterase 10A (PDE10) is a cyclic nucleotide (e.g. cGMP) degrading enzyme highly expressed in the brain striatum where it plays an important role in…”
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Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin by Lee, Kevin J, Chang, Wen-Chi L, Chen, Xi, Valiyaveettil, Jacob, Ramirez-Alcantara, Veronica, Gavin, Elaine, Musiyenko, Alla, Madeira da Silva, Luciana, Annamdevula, Naga S, Leavesley, Silas J, Ward, Antonio, Mattox, Tyler, Lindsey, Ashley S, Andrews, Joel, Zhu, Bing, Wood, Charles, Neese, Ashleigh, Nguyen, Ashley, Berry, Kristy, Maxuitenko, Yulia, Moyer, Mary Pat, Nurmemmedov, Elmar, Gorman, Greg, Coward, Lori, Zhou, Gang, Keeton, Adam B, Cooper, Harry S, Clapper, Margie L, Piazza, Gary A

“…Previous studies have reported that phosphodiesterase 10A (PDE10) is overexpressed in colon epithelium during early stages of colon tumorigenesis and essential…”
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The Landscape of Neutralizing Monoclonal Antibodies (nAbs) for Treatment and Prevention of COVID-19 by de Almeida Oliveira, Aline, Praia Borges Freire, Diana, Rodrigues de Andrade, Ana, de Miranda Marques, Amanda, da Silva Madeira, Luciana, Moreno Senna, José Procópio, Freitas Brasileiro da Silveira, Ivna Alana, de Castro Fialho, Beatriz

“…Purpose After nearly 3 years of the COVID-19 pandemic, even though a vast body of knowledge and products (including vaccines and treatments) have been…”
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Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer by Borneman, Rebecca M, Gavin, Elaine, Musiyenko, Alla, Richter, Wito, Lee, Kevin J, Crossman, David K, Andrews, Joel F, Wilhite, Annelise M, McClellan, Steven, Aragon, Ileana, Ward, Antonio B, Chen, Xi, Keeton, Adam B, Berry, Kristy, Piazza, Gary A, Scalici, Jennifer M, da Silva, Luciana Madeira

“…A leading theory for ovarian carcinogenesis proposes that inflammation associated with incessant ovulation is a driver of oncogenesis. Consistent with this…”
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Long-Term Follow-Up of Gemogenovatucel-T (Vigil) Survival and Molecular Signals of Immune Response in Recurrent Ovarian Cancer by Rocconi, Rodney P., Stanbery, Laura, Madeira da Silva, Luciana, Barrington, Robert A., Aaron, Phylicia, Manning, Luisa, Horvath, Staci, Wallraven, Gladice, Bognar, Ernest, Walter, Adam, Nemunaitis, John

“…Aim: To determine the relationship between gene expression profile (GEP) and overall survival (OS) by NanoString following treatment with Vigil. Patients and…”
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DNA damage measurements within tissue samples with Repair Assisted Damage Detection (RADD) by Lee, Kevin J., Mann, Elise, da Silva, Luciana Madeira, Scalici, Jennifer, Gassman, Natalie R.

“…Exposures to genotoxic carcinogens and reactive species result in strand breaks and a spectrum of covalent modifications to DNA that can induce mutations and…”
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Author Correction: ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer by Rocconi, Rodney P., Stanbery, Laura, Tang, Min, Madeira da Silva, Luciana, Walter, Adam, Monk, Bradley J., Herzog, Thomas J., Coleman, Robert L., Manning, Luisa, Wallraven, Gladice, Horvath, Staci, Bognar, Ernest, Senzer, Neil, Brun, Scott, Nemunaitis, John

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