Search Results - "Silva, Leyre"

Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 by Llopiz, Diana, Ruiz, Marta, Silva, Leyre, Sarobe, Pablo

“…Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these…”
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Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies by Aparicio, Belén, Ruiz, Marta, Casares, Noelia, Silva, Leyre, Egea, Josune, Pérez, Patricia, Albericio, Guillermo, Esteban, Mariano, García-Arriaza, Juan, Lasarte, Juan J, Sarobe, Pablo

“…Current vaccines against SARS-CoV-2, based on the original Wuhan sequence, induce antibodies with different degrees of cross-recognition of new viral variants…”
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Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer by Aparicio, Belén, Repáraz, David, Ruiz, Marta, Llopiz, Diana, Silva, Leyre, Vercher, Enric, Theunissen, Patrick, Tamayo, Ibon, Smerdou, Cristian, Igea, Ana, Santisteban, Marta, Gónzalez-Deza, Cristina, Lasarte, Juan J., Hervás-Stubbs, Sandra, Sarobe, Pablo

“…Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the…”
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Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance by Garza, Rocío García, Sarobe, Pablo, Merino, Juana, Lasarte, Juan J., D'Avola, Delia, Belsue, Virginia, Delgado, José A., Silva, Leyre, Iñarrairaegui, Mercedes, Sangro, Bruno, Sola, Jesus J., Pardo, Fernando, Quiroga, Jorge, Herrero, J. Ignacio

“…Recipients of liver transplantation (LT) may develop immunological tolerance. Factors predictive of tolerance are not clearly understood. Transplant recipients…”
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Erratum: Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies by Aparicio, Belén, Ruiz, Marta, Casares, Noelia, Silva, Leyre, Egea, Josune, Pérez, Patricia, Albericio, Guillermo, Esteban, Mariano, García-Arriaza, Juan, Lasarte, Juan J, Sarobe, Pablo

“…[This corrects the article DOI: 10.3389/fimmu.2022.1044025.]…”
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Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination by Repáraz, David, Ruiz, Marta, Silva, Leyre, Aparicio, Belén, Egea, Josune, Guruceaga, Elizabeth, Ajona, Daniel, Senent, Yaiza, Conde, Enrique, Navarro, Flor, Barace, Sergio, Alignani, Diego, Hervás-Stubbs, Sandra, Lasarte, Juan José, Llopiz, Diana, Sarobe, Pablo

“…Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. To enhance vaccine potency and improve…”
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Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses Against Hepatocellular Carcinoma by Silva, Leyre, Egea, Josune, Villanueva, Lorea, Ruiz, Marta, Llopiz, Diana, Repáraz, David, Aparicio, Belén, Lasarte-Cia, Aritz, Lasarte, Juan José, Ruiz de Galarreta, Marina, Lujambio, Amaia, Sangro, Bruno, Sarobe, Pablo

“…Therapies based on immune checkpoint inhibitors (ICPI) have yielded promising albeit limited results in patients with hepatocellular carcinoma (HCC). Vaccines…”
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Neoantigens as potential vaccines in hepatocellular carcinoma by Repáraz, David, Ruiz, Marta, Llopiz, Diana, Silva, Leyre, Vercher, Enric, Aparicio, Belén, Egea, Josune, Tamayo-Uria, Ibon, Hervás-Stubbs, Sandra, García-Balduz, Jorge, Castro, Carla, Iñarrairaegui, Mercedes, Tagliamonte, Maria, Mauriello, Angela, Cavalluzzo, Beatrice, Buonaguro, Luigi, Rohrer, Charlotte, Heim, Kathrin, Tauber, Catrin, Hofmann, Maike, Thimme, Robert, Sangro, Bruno, Sarobe, Pablo

“…BackgroundNeoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential…”
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The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer by Villanueva, Lorea, Silva, Leyre, Llopiz, Diana, Ruiz, Marta, Iglesias, Tamara, Lozano, Teresa, Casares, Noelia, Hervas-Stubbs, Sandra, Rodríguez, María José, Carrascosa, José L., Lasarte, Juan José, Sarobe, Pablo

“…Tumor infiltrating lymphocytes have been associated with a better prognostic and with higher response rates in patients treated with checkpoint inhibiting…”
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Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection by Zabaleta, Aintzane, D'Avola, Delia, Echeverria, Itziar, Llopiz, Diana, Silva, Leyre, Villanueva, Lorea, Riezu-Boj, José Ignacio, Larrea, Esther, Pereboev, Alexander, Lasarte, Juan José, Rodriguez-Lago, Iago, Iñarrairaegui, Mercedes, Sangro, Bruno, Prieto, Jesús, Sarobe, Pablo

“…The lack of antiviral cellular immune responses in patients with chronic hepatitis C virus (HCV) infection suggests that T-cell vaccines may provide…”
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Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model by Llopiz, Diana, Ruiz, Marta, Villanueva, Lorea, Iglesias, Tamara, Silva, Leyre, Egea, Josune, Lasarte, Juan J., Pivette, Perrine, Trochon-Joseph, Véronique, Vasseur, Bérangère, Dixon, Graham, Sangro, Bruno, Sarobe, Pablo

“…Immune checkpoint inhibitors are currently tested in different combinations in patients with advanced hepatocellular carcinoma (HCC). Nivolumab, an anti-PD-1…”
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Inhibition of adjuvant-induced TAM receptors potentiates cancer vaccine immunogenicity and therapeutic efficacy by Llopiz, Diana, Ruiz, Marta, Silva, Leyre, Repáraz, David, Aparicio, Belén, Egea, Josune, Lasarte, Juan J., Redin, Esther, Calvo, Alfonso, Angel, Matthew, Berzofsky, Jay A., Stroncek, David, Sarobe, Pablo

“…Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a…”
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IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination by Llopiz, Diana, Ruiz, Marta, Infante, Stefany, Villanueva, Lorea, Silva, Leyre, Hervas-Stubbs, Sandra, Alignani, Diego, Guruceaga, Elizabeth, Lasarte, Juan J, Sarobe, Pablo

“…Vaccination induces immunostimulatory signals that are often accompanied by regulatory mechanisms such as IL-10, which control T-cell activation and inhibit…”
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FRI476 - Identification of neoantigens as potential vaccines in hepatocellular carcinoma by Reparaz, David, Ruiz, Maria, Llopiz, Diana, Silva, Leyre, Vercher, Enric, Tamayo, Ibon, Hervás-Stubbs, Sandra, Lasarte, Juan J., Iñarrairaegui, Mercedes, Buonaguro, Luigi, Tagliamonte, Maria, Mauriello, Angela, Cavalluzzo, Beatrice, Sangro, Bruno, Sarobe, Pablo

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Identification of neoantigens as potential vaccines in hepatocellular carcinoma by Reparaz, David, Ruiz, Maria, Llopiz, Diana, Silva, Leyre, Vercher, Enric, Tamayo, Ibon, Hervás-Stubbs, Sandra, Lasarte, Juan J., Iñarrairaegui, Mercedes, Buonaguro, Luigi, Tagliamonte, Maria, Mauriello, Angela, Cavalluzzo, Beatrice, Sangro, Bruno, Sarobe, Pablo

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Immune monitoring of immunosuppression withdrawal of liver transplant recipients by García de la Garza, Rocío, Sarobe, Pablo, Merino, Juana, Lasarte, Juan J, D'Avola, Delia, Belsue, Virginia, Delgado, José A, Silva, Leyre, Iñarrairaegui, Mercedes, Sangro, Bruno, Sola, Iosu, Pardo, Fernando, Quiroga, Jorge, Ignacio Herrero, J

“…Abstract Several studies have shown that some liver transplant recipients may tolerate immunosuppression withdrawal. Mechanisms and biomarkers of tolerance are…”
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Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells by Echeverria, Itziar, Pereboev, Alexander, Silva, Leyre, Zabaleta, Aintzane, Riezu‐Boj, José Ignacio, Bes, Marta, Cubero, María, Borras‐Cuesta, Francisco, Lasarte, Juan José, Esteban, Juan Ignacio, Prieto, Jesús, Sarobe, Pablo

“…Injection of dendritic cells (DCs) presenting viral proteins constitutes a promising approach to stimulate T cell immunity against hepatitis C virus (HCV)…”
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Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance: Tolerance in Lt by de la Garza, Rocío García, Sarobe, Pablo, Merino, Juana, Lasarte, Juan J., D'Avola, Delia, Belsue, Virginia, Delgado, José A., Silva, Leyre, Iñarrairaegui, Mercedes, Sangro, Bruno, Sola, Jesus J., Pardo, Fernando, Quiroga, Jorge, Herrero, J. Ignacio

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Vaccination Against Hepatitis C Virus With Dendritic Cells Transduced With an Adenovirus Encoding NS3 Protein by Zabaleta, Aintzane, Llopiz, Diana, Arribillaga, Laura, Silva, Leyre, Riezu-Boj, José Ignacio, Lasarte, Juan José, Borrás-Cuesta, Francisco, Prieto, Jesús, Sarobe, Pablo

“…Chronic infection by hepatitis C virus (HCV) is characterized by the absence of efficient antiviral T-cell responses. Thus, vaccination strategies to induce…”
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