Search Results - "Silva, Johnatas D."

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis by Bandeira, Elga, Oliveira, Helena, Silva, Johnatas D, Menna-Barreto, Rubem F S, Takyia, Christina M, Suk, Jung S, Witwer, Kenneth W, Paulaitis, Michael E, Hanes, Justin, Rocco, Patricia R M, Morales, Marcelo M

“…Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory…”
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Extracellular Vesicles from Different Sources of Mesenchymal Stromal Cells Have Distinct Effects on Lung and Distal Organs in Experimental Sepsis by Blanco, Natália G, Machado, Natália M, Castro, Ligia L, Antunes, Mariana A, Takiya, Christina M, Trugilho, Monique R O, Silva, Luana R, Paes Leme, Adriana F, Domingues, Romênia R, Pauletti, Bianca A, Miranda, Beatriz T, Silva, Johnatas D, Dos Santos, Claudia C, Silva, Pedro L, Rocco, Patricia R M, Cruz, Fernanda F

“…The effects of the administration of mesenchymal stromal cells (MSC) may vary according to the source. We hypothesized that MSC-derived extracellular vesicles…”
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Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis by Carneiro, Priscila J, Clevelario, Amanda L, Padilha, Gisele A, Silva, Johnatas D, Kitoko, Jamil Z, Olsen, Priscilla C, Capelozzi, Vera L, Rocco, Patricia R M, Cruz, Fernanda F

“…Silicosis is an occupational lung disease for which no effective therapy exists. We hypothesized that bosutinib, a tyrosine kinase inhibitor, might ameliorate…”
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Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model by Gonzalez, Hector, McCarthy, Sean, Masterson, Claire, Byrnes, Declan, Sallent, Ignacio, Horan, Emma, Elliman, Stephen J, Vella, Gabriele, Prina-Mello, Adriele, Silva, Johnatas D, Krasnodembskaya, Anna D, MacLoughlin, Ronan, Laffey, John G, O'Toole, Daniel

“…Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have been proposed as an alternative to cell therapy, creating new possible delivery…”
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Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis by Silva, Johnatas D, Lopes-Pacheco, Miquéias, de Castro, Ligia L, Kitoko, Jamil Z, Trivelin, Stefano A, Amorim, Natália R, Capelozzi, Vera L, Morales, Marcelo M, Gutfilen, Bianca, de Souza, Sergio A L, Weiss, Daniel J, Diaz, Bruno L, Rocco, Patricia R M

“…Even though mesenchymal stromal cells (MSCs) mitigate lung and distal organ damage in experimental polymicrobial sepsis, mortality remains high. We…”
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Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology by Lopes-Pacheco, Miquéias, Cruz, Fernanda F., Rocco, Patricia R. M., dos Santos, Claudia C., Morales, Marcelo M., Barbosa-Junior, Carlos M., Trivelin, Stefano A., De Oliveira, Gisele P., Braga, Cassia L., de Castro, Ligia L., Silva, Johnatas D., Weiss, Daniel J.

“…Although mesenchymal stromal cells (MSCs) have demonstrated beneficial effects on experimental acute respiratory distress syndrome (ARDS), preconditioning may…”
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The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis by Gonçalves-de-Albuquerque, Cassiano Felippe, Rohwedder, Ina, Silva, Adriana Ribeiro, Ferreira, Alessandra Silveira, Kurz, Angela R M, Cougoule, Céline, Klapproth, Sarah, Eggersmann, Tanja, Silva, Johnatas D, de Oliveira, Gisele Pena, Capelozzi, Vera Luiza, Schlesinger, Gabriel Gutfilen, Costa, Edlaine Rijo, Estrela Marins, Rita de Cassia Elias, Mócsai, Attila, Maridonneau-Parini, Isabelle, Walzog, Barbara, Macedo Rocco, Patricia Rieken, Sperandio, Markus, de Castro-Faria-Neto, Hugo Caire

“…Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune…”
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Effects of pressure support and pressure-controlled ventilation on lung damage in a model of mild extrapulmonary acute lung injury with intra-abdominal hypertension by Santos, Cintia L, Santos, Raquel S, Moraes, Lillian, Samary, Cynthia S, Felix, Nathane S, Silva, Johnatas D, Morales, Marcelo M, Huhle, Robert, Abreu, Marcelo G, Schanaider, Alberto, Silva, Pedro L, Pelosi, Paolo, Rocco, Patricia R M

“…Intra-abdominal hypertension (IAH) may co-occur with the acute respiratory distress syndrome (ARDS), with significant impact on morbidity and mortality…”
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Effects of Bone Marrow–Derived Mononuclear Cells From Healthy or Acute Respiratory Distress Syndrome Donors on Recipient Lung-Injured Mice by Silva, Johnatas D, Paredes, Bruno D, Araújo, Indianara M, Lopes-Pacheco, Miquéias, Oliveira, Milena V, Suhett, Grazielle D, Faccioli, Lanuza A P, Assis, Edson, Castro-Faria-Neto, Hugo C, Goldenberg, Regina C S, Capelozzi, Vera L, Morales, Marcelo M, Pelosi, Paolo, Xisto, Débora G, Rocco, Patricia R M

“…OBJECTIVE:The advantage of using autologous bone marrow–derived mononuclear cells to treat acute respiratory distress syndrome patients is to prevent…”
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The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology by Oliveira, Gisele P., Silva, Johnatas D., Marques, Patricia S., Gonçalves-de-Albuquerque, Cassiano F., Santos, Heloísa L., Vascocellos, Ana Paula, Takiya, Christina M., Morales, Marcelo M., Pelosi, Paolo, Mócsai, Attila, de Castro-Faria-Neto, Hugo C., Rocco, Patricia R.M.

“…Background/Aims: Evidence suggests that tyrosine-kinase inhibitors may attenuate lung inflammation and fibrosis in experimental acute respiratory distress…”
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Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model by Cruz, Fernanda F, Antunes, Mariana A, Abreu, Soraia C, Fujisaki, Lívia C, Silva, Johnatas D, Xisto, Débora G, Maron-Gutierrez, Tatiana, Ornellas, Debora S, Sá, Vanessa K, Rocha, Nazareth N, Capelozzi, Vera L, Morales, Marcelo M, Rocco, Patricia R.M

“…Highlights ► Bone marrow cells had a protective effect on lung and heart in emphysema. ► Bone marrow cells modulated inflammation and remodeling in emphysema…”
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Corrigendum: Differential Regulation of Thyroid Hormone Metabolism Target Genes during Non-thyroidal Illness Syndrome Triggered by Fasting or Sepsis in Adult Mice by Fontes, Klaus N, Cabanelas, Adriana, Bloise, Flavia F, de Andrade, Cherley Borba Vieira, Souza, Luana L, Wilieman, Marianna, Trevenzoli, Isis H, Agra, Lais C, Silva, Johnatas D, Bandeira-Melo, Christianne, Silva, Pedro L, Rocco, Patricia R M, Ortiga-Carvalho, Tania M

“…[This corrects the article on p. 828 in vol. 8, PMID: 29118715.]…”
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Differential Regulation of Thyroid Hormone Metabolism Target Genes during Non-thyroidal [corrected] Illness Syndrome Triggered by Fasting or Sepsis in Adult Mice by Fontes, Klaus N, Cabanelas, Adriana, Bloise, Flavia F, de Andrade, Cherley Borba Vieira, Souza, Luana L, Wilieman, Marianna, Trevenzoli, Isis H, Agra, Lais C, Silva, Johnatas D, Bandeira-Melo, Christianne, Silva, Pedro L, Rocco, Patricia R M, Ortiga-Carvalho, Tania M

“…Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the…”
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Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma by Saraiva, Simone A, Silva, Adriana L, Xisto, Débora G, Abreu, Soraia C, Silva, Johnatas D, Silva, Pedro L, Teixeira, Tatiana P.F, Parra, Edwin R, Carvalho, Ana Laura N, Annoni, Raquel, Mauad, Thais, Capelozzi, Vera L, Silva, Patricia M.R, Martins, Marco A, Rocco, Patricia R.M

“…Abstract The impact of obesity on the inflammatory process has been described in asthma, however little is known about the influence of diet-induced obesity on…”
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Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome by Silva, Johnatas D., Lopes-Pacheco, Miquéias, Paz, Ana H. R., Cruz, Fernanda F., Melo, Elga B., de Oliveira, Milena V., Xisto, Débora G., Capelozzi, Vera L., Morales, Marcelo M., Pelosi, Paolo, Cirne-Lima, Elizabeth, Rocco, Patricia R. M.

“…OBJECTIVES:Mesenchymal stem cells–based therapies have shown promising effects in experimental acute respiratory distress syndrome. Different mesenchymal stem…”
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Effects of Mesenchymal Stem Cell Therapy on the Time Course of Pulmonary Remodeling Depend on the Etiology of Lung Injury in Mice by Maron-Gutierrez, Tatiana, Silva, Johnatas D, Asensi, Karina D, Bakker-Abreu, Ilka, Shan, Yuexin, Diaz, Bruno L, Goldenberg, Regina C S, Mei, Shirley H J, Stewart, Duncan J, Morales, Marcelo M, Rocco, Patricia R M, Dos Santos, Claudia C

“…OBJECTIVE:Recent evidence suggests that mesenchymal stem cells may attenuate lung inflammation and fibrosis in acute lung injury. However, so far, no study has…”
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Therapeutic effect of Lipoxin A 4  in malaria-induced acute lung injury by Pádua, Tatiana A, Torres, Natalia D, Candéa, André L P, Costa, Maria Fernanda Souza, Silva, Johnatas D, Silva-Filho, João Luiz, Costa, Fabio T M, Rocco, Patricia R M, Souza, Mariana C, Henriques, Maria G

“…Acute lung injury (ALI) models are characterized by neutrophil accumulation, tissue damage, alteration of the alveolar capillary membrane, and physiological…”
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Sevoflurane, Compared With Isoflurane, Minimizes Lung Damage in Pulmonary but Not in Extrapulmonary Acute Respiratory Distress Syndrome in Rats by Araújo, Mariana N, Santos, Cíntia L, Samary, Cynthia S, Heil, Luciana B B, Cavalcanti, Vinicius C M, Cruz, Fernanda F, Felix, Nathane S, Silva, Johnatas D, Morales, Marcelo M, Pelosi, Paolo, Fernandes, Fatima C, Villela, Nivaldo R, Silva, Pedro L, Rocco, Patricia R M

“…BACKGROUND:Volatile anesthetics modulate inflammation in acute respiratory distress syndrome (ARDS). However, it is unclear whether they act differently…”
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Therapeutic effect of Lipoxin A4 in malaria‐induced acute lung injury by Pádua, Tatiana A., Torres, Natalia D., Candéa, André L. P., Costa, Maria Fernanda Souza, Silva, Johnatas D., Silva‐Filho, João Luiz, Costa, Fabio T. M., Rocco, Patricia R. M., Souza, Mariana C., Henriques, Maria G.

“…Acute lung injury (ALI) models are characterized by neutrophil accumulation, tissue damage, alteration of the alveolar capillary membrane, and physiological…”
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Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury by de Araújo, Carla C, Silva, Johnatas D, Samary, Cynthia S, Guimarães, Isabela H, Marques, Patrícia S, Oliveira, Gisele P, do Carmo, Luana G R R, Goldenberg, Regina C, Bakker-Abreu, Ilka, Diaz, Bruno L, Rocha, Nazareth N, Capelozzi, Vera L, Pelosi, Paolo, Rocco, Patricia R M

“…Physical activity modulates inflammation and immune response in both normal and pathologic conditions. We investigated whether regular and moderate exercise…”
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