microRNAs deregulation in head and neck squamous cell carcinoma

microRNAs deregulation in head and neck squamous cell carcinoma

Head and neck (HN) squamous cell carcinoma (SCC) is the eighth most common human cancer worldwide. Besides tobacco and alcohol consumption, genetic and epigenetic alterations play an important role in HNSCC occurrence and progression. microRNAs (miRNAs) are small noncoding RNAs that regulate cell cy...

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Bibliographic Details
Published in:Head & neck Vol. 43; no. 2; pp. 645 - 667
Main Authors: Carron, Juliana, Torricelli, Caroline, Silva, Janet K., Queiroz, Gabriela S. R., Ortega, Manoela M., Lima, Carmen S. P., Lourenço, Gustavo J.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-02-2021
Wiley Subscription Services, Inc
Subjects:
Apoptosis
Cell cycle
Cell differentiation
Epigenetics
Gene expression
Head & neck cancer
head and neck cancer
MicroRNAs
miRNA
SNVs
Squamous cell carcinoma
therapy
Tobacco
Tumor cells
microRNAs
head and neck cancer
therapy
SNVs
epigenetics
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Summary:Head and neck (HN) squamous cell carcinoma (SCC) is the eighth most common human cancer worldwide. Besides tobacco and alcohol consumption, genetic and epigenetic alterations play an important role in HNSCC occurrence and progression. microRNAs (miRNAs) are small noncoding RNAs that regulate cell cycle, proliferation, development, differentiation, and apoptosis by interfering in gene expression. Expression profiling of miRNAs showed that some miRNAs are upregulated or downregulated in tumor cells when compared with the normal cells. The present review focuses on the role of miRNAs deregulations in HNSCC, enrolled in risk, development, outcome, and therapy sensitivity. Moreover, the influence of single nucleotide variants in miRNAs target sites, miRNAs seed sites, and miRNAs‐processing genes in HNSCC was also revised. Due to its potential for cancer diagnosis, progression, and as a therapeutic target, miRNAs may bring new perspectives in HNSCC understanding and therapy, especially for those patients with no or insufficient treatment options.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26533