Renal histopathological findings in dogs with visceral leishmaniasis

Renal histopathological findings in dogs with visceral leishmaniasis

Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory chang...

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Published in:Revista do Instituto de Medicina Tropical de São Paulo Vol. 55; no. 2; pp. 113 - 116
Main Authors: Rigo, Rosangela Silva, Carvalho, Cristiano Marcelo Espínola, Honer, Michael Robin, Andrade, Gisele Braziliano de, Silva, Iandara Shetter, Rigo, Leonardo, Figueiredo, Helen Rezende, Barreto, Wanessa Teixeira Gomes
Format: Journal Article
Language:English
Published: Brazil Instituto de Medicina Tropical de Sao Paulo 01-03-2013
Instituto de Medicina Tropical
Universidade de São Paulo (USP)
Subjects:
Animals
Dog Diseases - parasitology
Dog Diseases - pathology
Dogs
Female
Glomerulonephritis - parasitology
Glomerulonephritis - pathology
Glomerulonephritis - veterinary
Kidney - pathology
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - pathology
Leishmaniasis, Visceral - veterinary
Male
Renal histopathology
TROPICAL MEDICINE
Visceral leishmaniasis
Renal histopathology
Visceral leishmaniasis
Dogs
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Summary:Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory changes were present in 25.3% of the tubules, in 67.0% of interstitium and in 52.0% of glomeruli. There was no significant difference (p > 0.05) between the presence of glomerulonephritis in symptomatic and oligosymptomatic dogs. The membranous and membranoproliferative glomerulonephritis were the most frequent, both with 18.0% frequency, followed by focal segmental glomerulosclerosis with 14.0%. Changes such as cylindruria, tubular and fibrosis hypertrophy, periglomerular inflammatory infiltrate, and multifocal and diffuse peritubular inflammatory infiltrate were observed. The findings are consistent with those of other authors indicating that renal involvement is common in CVL and the standards of membranous and membranoploriferative glomerulonephritis, as well as the tubulointerstitial involvement, are frequent.
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ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46652013000200008