Search Results - "Silva, Franck"

IChem: A Versatile Toolkit for Detecting, Comparing, and Predicting Protein–Ligand Interactions by Da Silva, Franck, Desaphy, Jeremy, Rognan, Didier

“…Structure‐based ligand design requires an exact description of the topology of molecular entities under scrutiny. IChem is a software package that reflects the…”
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Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors by Tsimberidou, Apostolia M, Beer, Philip A, Cartwright, Carrie A, Haymaker, Cara, Vo, Henry H, Kiany, Simin, Cecil, Alexander R L, Dow, James, Haque, Kemal, Silva, Franck A, Coe, Lucy, Berryman, Helen, Bone, Elisabeth A, Nogueras-Gonzalez, Graciela M, Vining, David, McElwaine-Johnn, Hilary, Wistuba, Ignacio I

“…Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study…”
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IChemPIC: A Random Forest Classifier of Biological and Crystallographic Protein–Protein Interfaces by Da Silva, Franck, Desaphy, Jérémy, Bret, Guillaume, Rognan, Didier

“…Protein–protein interactions are becoming a major focus of academic and pharmaceutical research to identify low molecular weight compounds able to modulate…”
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Game on, science - how video game technology may help biologists tackle visualization challenges by Lv, Zhihan, Tek, Alex, Da Silva, Franck, Empereur-mot, Charly, Chavent, Matthieu, Baaden, Marc

“…The video games industry develops ever more advanced technologies to improve rendering, image quality, ergonomics and user experience of their creations…”
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Docking pose selection by interaction pattern graph similarity: application to the D3R grand challenge 2015 by Slynko, Inna, Da Silva, Franck, Bret, Guillaume, Rognan, Didier

“…High affinity ligands for a given target tend to share key molecular interactions with important anchoring amino acids and therefore often present quite…”
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Ranking docking poses by graph matching of protein–ligand interactions: lessons learned from the D3R Grand Challenge 2 by da Silva Figueiredo Celestino Gomes, Priscila, Da Silva, Franck, Bret, Guillaume, Rognan, Didier

“…A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict the pose and affinity ranking of a set of Farnesoid X…”
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Enantioselective Organocatalytic Aldol Reaction of Ynones and Its Synthetic Applications by Silva, Franck, Sawicki, Marcin, Gouverneur, Véronique

“…For the first time, unmodified ynones were used in organocatalytic asymmetric aldol reactions delivering monoprotected anti-α,β-dihydroxyynones in high yields,…”
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Preclinical and phase I studies of KA2237, a selective and potent inhibitor of PI3K β/δ in relapsed refractory B cell lymphoma by Nastoupil, Loretta J., Neelapu, Sattva S., Davis, Richard Eric, Samaniego, Felipe, Fowler, Nathan H., Westin, Jason, Lee, Hun Ju, Wang, Michael, Hagemeister, Fredrick, Cecil, Alexander R. L., Dow, James, Haque, Kemal, Silva, Franck A., Whale, Andrew, Lensun, Letitia, Bone, Elisabeth A., McElwaine-Johnn, Hilary, Beer, Philip A.

“…PI3-kinase p110δ is mainly expressed in lymphocytes and is an attractive therapeutic target in B cell lymphomas. Targeting p110β may further suppress tumor…”
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Pd(II)-Catalyzed Cascade Wacker−Heck Reaction:  Chemoselective Coupling of Two Electron-Deficient Reactants by Silva, Franck, Reiter, Maud, Mills-Webb, Rebecca, Sawicki, Marcin, Klär, Daniel, Bensel, Nicolas, Wagner, Alain, Gouverneur, Véronique

“…A novel palladium(II)-catalyzed oxy-carbopalladation process was developed allowing for the orchestrated union of hydroxy ynones with ethyl acrylate, two…”
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Modeling complex biological systems: From solution chemistry to membranes and channels by Laurent, Benoist, Murail, Samuel, Da Silva, Franck, Corringer, Pierre-Jean, Baaden, Marc

“…Complex biological systems are intimately linked to their environment, a very crowded and equally complex solution compartmentalized by fluid membranes…”
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Unsupervised Classification of G‑Protein Coupled Receptors and Their Conformational States Using IChem Intramolecular Interaction Patterns by Koensgen, Florian, Da Silva, Franck, Rognan, Didier, Kellenberger, Esther

“…Over the past decade, the ever-growing structural information on G-protein coupled receptors (GPCRs) has revealed the three-dimensional (3D) characteristics of…”
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All in One: Cavity Detection, Druggability Estimate, Cavity-Based Pharmacophore Perception, and Virtual Screening by Tran-Nguyen, Viet-Khoa, Da Silva, Franck, Bret, Guillaume, Rognan, Didier

“…Discovering the very first ligands of pharmacologically important targets in a fast and cost-efficient manner is an important issue in drug discovery. In the…”
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Exhaustive Repertoire of Druggable Cavities at Protein–Protein Interfaces of Known Three-Dimensional Structure by Da Silva, Franck, Bret, Guillaume, Teixeira, Leandro, Gonzalez, Claudio F, Rognan, Didier

“…Protein–protein interactions (PPIs) offer the unique opportunity to tailor ligands aimed at specifically stabilizing or disrupting the corresponding interfaces…”
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Gold(I)-Catalyzed Alkoxyhalogenation of β-Hydroxy-α,α-Difluoroynones by Schuler, Marie, Silva, Franck, Bobbio, Carla, Tessier, Arnaud, Gouverneur, Véronique

“…Gold standard: AuCl was found to be the only suitable catalyst for the 6‐endo‐dig ring closure of hydroxylated difluorinated ynones (see scheme), a class of…”
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IChem:AVersatile Toolkit for Detecting, Comparing, and Predicting Protein-Ligand Interactions by da Silva, Franck, Desaphy, Jérémy, Rognan, Didier

“…Structure-based ligand design requires an exact description of the topology of molecular entitiesu nder scrutiny.I Chem is a softwarep ackage that reflects the…”
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Contribuição para a Determinação da Separação Geoide e Quase Geoide (SGQG) no Território Brasileiro by Silva, Franck Rosa da, Souza, Sérgio Florêncio de, Santos Junior, Roosevelt de Lara, Ferraz, Rodrigo da Silva

“…A separação entre o geoide e o quase geoide, entendida como a diferença entre as altitudes normal e ortométrica, pode ser da ordem de centímetros, chegando a…”
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Results of a First in Human, Dose Ascending, Phase I Study Examining the Safety and Tolerability of KA2237, an Oral PI3K p110β/δ Inhibitor in Patients with Relapsed/Refractory (R/R) B-Cell Lymphoma by Nastoupil, Loretta J., Neelapu, Sattva S, Davis, Eric, Samaniego, Felipe, Fowler, Nathan H, Westin, Jason R., Lee, Hun Ju, Wang, Michael, Hagemeister, Fredrick B., Beer, Philip, Cecil, Alexander R.L., Dow, James, McHale, Duncan, Silva, Franck, Ward, Penny, Yavari, Arash, Shuttleworth, Stephen Joseph

“…Introduction: Despite therapeutic advances, there remains a considerable need for novel therapies for B-cell lymphomas. Although a high proportion of patients…”
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Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling by Briolotti, Philippe, Chaloin, Laurent, Balaguer, Patrick, Da Silva, Franck, Tománková, Veronika, Pascussi, Jean-Marc, Duret, Cédric, Fabre, Jean-Michel, Ramos, Jeanne, Klieber, Sylvie, Maurel, Patrick, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine

“…Cytochrome P450 (CYP) expression and activity are not homogeneous in the liver lobules. Indeed, CYPs are mainly expressed and induced in centrilobular…”
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Elongation of β-hydroxyenones by cross-metathesis by Silva, Franck A., Gouverneur, Véronique

“…Enantioenriched aldol products derived from enones are notoriously difficult to prepare due to their sensitivity to retro-aldolisation, elimination and the…”
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Inside Cover: Gold(I)-Catalyzed Alkoxyhalogenation of β-Hydroxy-α,α-Difluoroynones (Angew. Chem. Int. Ed. 41/2008) by Schuler, Marie, Silva, Franck, Bobbio, Carla, Tessier, Arnaud, Gouverneur, Véronique

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