Search Results - "Silva, Fábio H"

Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment by Silva, Fábio H, Karakus, Serkan, Musicki, Biljana, Matsui, Hotaka, Bivalacqua, Trinity J, Dos Santos, Jean L, Costa, Fernando F, Burnett, Arthur L

“…Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current…”
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Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: reversal by the sGC activator BAY 60-2770 by Alexandre, Eduardo C, Leiria, Luiz O, Silva, Fábio H, Mendes-Silvério, Camila B, Calmasini, Fabiano B, Davel, Ana Paula C, Mónica, Fabíola Z, De Nucci, Gilberto, Antunes, Edson

“…Obesity has emerged as a major contributing risk factor for overactive bladder (OAB), but no study examined urethral smooth muscle (USM) dysfunction as a…”
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Long‐term treatment with the beta‐3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice by Calmasini, Fabiano B., de Oliveira, Mariana G., Alexandre, Eduardo C., da Silva, Fábio H., da Silva, Carmem P.V., Candido, Tuany Z., Antunes, Edson, Mónica, Fabíola Z.

“…Aims To evaluate the effects of the beta‐3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity. Methods C57BL/6 male…”
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High‐fat diet associated with obesity induces impairment of mouse corpus cavernosum responses by Toque, Haroldo A., da Silva, Fábio H., Calixto, Marina C., Lintomen, Letícia, Schenka, André A., Saad, Mario J., Zanesco, Angelina, Antunes, Edson

“…Study Type – Aetiology (case control) 
Level of Evidence 3b What’s known on the subject? and What does the study add? Erectile dysfunction (ED) is defined as…”
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Vas deferens smooth muscle responses to the nitric oxide-independent soluble guanylate cyclase stimulator BAY 41‐2272 by da Silva, Fábio H., Claudino, Mário A., Báu, Fernando R., Rojas-Moscoso, Julio A., Mónica, Fabíola Z., De Nucci, Gilberto, Antunes, E.

“…The nitric oxide–cGMP signaling pathway modulates the ejaculatory functions. The nitric oxide (NO)-independent soluble guanylate cyclase haem-dependent…”
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Urinary dysfunction in transgenic sickle cell mice: model of idiopathic overactive bladder syndrome by Karakus, Serkan, Anele, Uzoma A, Silva, Fábio H, Musicki, Biljana, Burnett, Arthur L

“…Voiding abnormalities are common among the sickle cell disease (SCD) population, among which overactive bladder (OAB) syndrome is observed at rates as high as…”
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Sympathetic Hyperactivity, Increased Tyrosine Hydroxylase and Exaggerated Corpus Cavernosum Relaxations Associated with Oxidative Stress Plays a Major Role in the Penis Dysfunction in Townes Sickle Cell Mouse by Silva, Fábio H, Claudino, Mário A, Calmasini, Fabiano B, Alexandre, Eduardo C, Franco-Penteado, Carla, Burnett, Arthur L, Antunes, Edson, Costa, Fernando F

“…Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of…”
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Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum by Silva, Fábio H, Lanaro, Carolina, Leiria, Luiz Osório, Rodrigues, Renata Lopes, Davel, Ana Paula, Claudino, Mário A, Toque, Haroldo A, Antunes, Edson

“…Impairment of nitric oxide (NO)-mediated cavernosal relaxations in middle age contributes to erectile dysfunction. However, little information is available…”
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Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance by Silva, Fábio H, Alexandre, Eduardo C, Calmasini, Fabiano B, Calixto, Marina C, Antunes, Edson

“…Objective To evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction. Material and Methods C57BL/6 male…”
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Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment by Alexandre, Eduardo C., Calmasini, Fabiano B., Sponton, Amanda C.da S., de Oliveira, Mariana G., André, Diana M., Silva, Fábio H., Delbin, Maria Andréia, Mónica, Fabíola Z., Antunes, Edson

“…Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose…”
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Chronic treatment with resveratrol improves overactive bladder in obese mice via antioxidant activity by Alexandre, Eduardo C., Calmasini, Fabiano B., de Oliveira, Mariana G., Silva, Fábio H., da Silva, Carmem P.V., André, Diana M., Leonardo, Flávia C., Delbin, Maria A., Antunes, Edson

“…The objective of the present work was to evaluate whether oral intake with resveratrol ameliorates overactive bladder in high-fat fed mice. Male C57BL6 mice…”
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The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice by Leiria, Luiz O, Silva, Fabio H, Davel, Ana Paula C, Alexandre, Eduardo C, Calixto, Marina C, De Nucci, Gilberto, Mónica, Fabíola Z, Antunes, Edson

“…Activators of soluble guanylyl cyclase are of potential interest as treatment for cardiovascular diseases but to our knowledge they have never been proposed to…”
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On the security aspects of Internet of Things: A systematic literature review by Macedo, Evandro L. C., de Oliveira, Egberto A. R., Silva, Fabio H., Mello, Rui R., Franca, Felipe M. G., Delicato, Flavia C., de Rezende, Jose F., de Moraes, Luis F. M.

“…Internet of Things (IoT) has gained increasing visibility among emerging technologies and undoubtedly changing our daily life. Its adoption is strengthened by…”
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Lipopolysaccharide reduces urethral smooth muscle contractility via cyclooxygenase activation by Calmasini, Fabiano B., Alexandre, Eduardo C., Oliveira, Mariana G., Silva, Fábio H., Soares, António G., Costa, Soraia K.P., Antunes, Edson

“…Lipopolysaccharide (LPS) is a component of gram-negative bacteria wall that elicits inflammatory response in the host through the toll-like receptor 4 (TLR4)…”
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How important is the α 1 -adrenoceptor in primate and rodent proximal urethra? Sex differences in the contribution of α 1 -adrenoceptor to urethral contractility by Alexandre, Eduardo C, de Oliveira, Mariana G, Campos, Rafael, Kiguti, Luiz R, Calmasini, Fabiano B, Silva, Fábio H, Grant, Andrew D, Yoshimura, Naoki, Antunes, Edson

“…Urethral smooth muscle (USM) contributes to urinary continence by contracting during the urine storage phase, which is mainly mediated by activation of…”
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Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle‐Aged Rats: Prevention by Antioxidant Therapy by Silva, Fábio H., Mónica, Fabíola Z., Báu, Fernando R., Brugnerotto, Ana F., Priviero, Fernanda B.M., Toque, Haroldo A., Antunes, Edson

“…Prevalence of erectile dysfunction (ED) increases progressively with aging, but the ED pathophysiology at its early stages is still poorly investigated. This…”
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Prolonged Therapy with the Soluble Guanylyl Cyclase Activator BAY 60-2770 Restores the Erectile Function in Obese Mice by Silva, Fábio H., Leiria, Luiz O., Alexandre, Eduardo C., Davel, Ana Paula C., Mónica, Fabíola Z., De Nucci, Gilberto, Antunes, Edson

“…Cardiovascular and endocrine-metabolic diseases associated with increased oxidative stress such as obesity lead to erectile dysfunction (ED). Activators of…”
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Implication of Rho‐kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle‐aged rats by Calmasini, Fabiano B., Silva, Fabio H., Alexandre, Eduardo C., Rodrigues, Renata L., Barbosa, Ana Paula L., Ferrucci, Danilo L., Carvalho, Hernandes F., Anhê, Gabriel F., Pupo, Andre S., Antunes, Edson

“…Aims Aging is highly associated with benign prostate hyperplasia (BPH). We investigated here the alterations of the contractile and relaxant machinery in…”
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Circulating Concentrations of Adipocytokines and Their Receptors in the Isolated Corpus Cavernosum and Femoral Artery from Trained Rats on a High-Fat Diet by Sponton, Amanda C S, Silva, Fábio H, Araujo, Hygor N, Valgas da Silva, Carmem P, de Moraes, Camila, Antunes, Edson, Zanesco, Angelina, Delbin, Maria A

“…The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity…”
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TSPO ligand FGIN‐1‐27 controls priapism in sickle cell mice via endogenous testosterone production by Musicki, Biljana, Karakus, Serkan, La Favor, Justin D., Chen, Haolin, Silva, Fabio H., Sturny, Mikael, Zirkin, Barry R., Burnett, Arthur L.

“…Priapism, a prolonged penile erection in the absence of sexual arousal, is common among patients with sickle cell disease (SCD). Hypogonadism is also common in…”
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