Clinical predictors of inducible sustained ventricular tachycardia during electrophysiologic study in patients with chronic Chagas' heart disease

Clinical independent predictors of inducible sustained ventricular tachycardia (VT) during electrophysiologic study (EPS) are not known in patients with chronic Chagas' heart disease. The purpose of this investigation was to fill this gap. The medical charts of 47 patients with a positive serol...

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Bibliographic Details
Published in:	International journal of cardiology. Heart & vasculature Vol. 9; no. C; pp. 85 - 88
Main Authors:	Cardinalli-Neto, Augusto, Lorga-Filho, Adalberto M., Silva, Elissandro F., Lima, Renata P., Palmegiani, Eduardo, Bestetti, Reinaldo B.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 07-12-2015 Elsevier
Subjects:	Amiodarone Arrhythmias Chagas' disease Electrophysiologic study Trypanosoma cruzi Amiodarone Chagas' disease Arrhythmias Trypanosoma cruzi Electrophysiologic study
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Summary:	Clinical independent predictors of inducible sustained ventricular tachycardia (VT) during electrophysiologic study (EPS) are not known in patients with chronic Chagas' heart disease. The purpose of this investigation was to fill this gap. The medical charts of 47 patients with a positive serology for Chagas' disease who had undergone EPS between September 2006 and July 2012 at our institution were reviewed. Reasons for the EPS were the presence of unexplained syncope, non-sustained ventricular tachycardia (NSVT) on either resting ECG or 24h-Holter monitoring as well as a LVEF<55% and >35% at echocardiography. A stepwise logistic regression analysis was performed to identify noninvasive predictors of inducible sustained VT/ventricular fibrillation during EPS. On univariate analysis, syncopal episodes (p=0.04), amiodarone therapy (p<0.005), diastolic blood pressure (p=0.03), creatinine serum levels (p<0.001), potassium serum levels (p<0.001), and lengthening of the QRS complex (p=0.03) were associated with inducible sustained VT during EPS. In the multivariate model, amiodarone therapy (p=0.03; hazard ratio=10; Wald coefficient=4.5; 95% confidence interval 1.2 to 85.2) was the only variable retained as independent predictor of inducible sustained VT during EPS. Amiodarone therapy was the only independent variable associated with sustained VT inducibility during EPS in patients with chronic Chagas' heart disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-9067 2352-9067
DOI:	10.1016/j.ijcha.2015.10.001