Search Results - "Silva, Edeíldo F."

Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies by Silva, Marina M., Nascimento, Eduarda O.O., Silva, Edeíldo F., Araújo, João Xavier de, Santana, Camilla C., Grillo, Luciano Aparecido M., de Oliveira, Rafaela S., R.R.Costa, Paulo, Buarque, Camilla D., Santos, Josué Carinhanha C., Figueiredo, Isis M.

“…The interaction of small molecules with DNA has been quite important, since this biomolecule is currently the major target for a wide range of drugs in…”
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Interaction of β-Carbolines with DNA: Spectroscopic Studies, Correlation with Biological Activity and Molecular Docking by Silva, Marina M., Savariz, Franciele C., Silva-Júnior, Edeíldo F., Aquino, Thiago M. de, Sarragiotto, Maria Helena, Santos, Josué C. C., Figueiredo, Isis M.

“…Quantitative interaction of twelve β-carboline derivatives with calf thymus deoxyribonucleic acid (ctDNA) using spectroscopic techniques was evaluated. The…”
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Entry Inhibitors of RNA Viruses by Silva-Júnior, Edeildo F da

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Annonalide and derivatives: Semisynthesis, cytotoxic activities and studies on interaction of annonalide with DNA by Marques, Ricardo A., Gomes, Akenaton O.C.V., de Brito, Maria V., dos Santos, Ana L.P., da Silva, Gladyane S., de Lima, Leandro B., Nunes, Fátima M., de Mattos, Marcos C., de Oliveira, Fátima C.E., do Ó Pessoa, Cláudia, de Moraes, Manoel O., de Fátima, Ângelo, Franco, Lucas L., Silva, Marina de M., Dantas, Maria Dayanne de A., Santos, Josué C.C., Figueiredo, Isis M., da Silva-Júnior, Edeíldo F., de Aquino, Thiago M., de Araújo-Júnior, João X., de Oliveira, Maria C.F., Leslie Gunatilaka, A.A.

“…The cytotoxic activity of the pimarane diterpene annonalide (1) and nine of its semisynthetic derivatives (2–10) was investigated against the human tumor cell…”
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Targeting Chikungunya Virus Entry: Alternatives for New Inhibitors in Drug Discovery by Silva, Leandro Rocha, Rodrigues, Érica Erlanny da Silva, Taniele-Silva, Jamile, Anderson, Letícia, Araújo-Júnior, João Xavier de, Bassi, Ênio José, Silva-Júnior, Edeildo F da

“…Chikungunya virus (CHIKV) is an Alphavirus (Togaviridae) responsible for Chikungunya fever (CHIKF) that is mainly characterized by a severe polyarthralgia, in…”
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Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration by Freitas, Priscilla R., de Araújo, Ana C.J., Araújo, Isaac M., de Almeida, Ray S., Borges, João A.O., Paulo, Cícera L.R., Oliveira-Tintino, Cícera D.M., Miranda, Gustavo M., Araújo-Neto, José B., Nascimento, Igor J.S., Araújo-Júnior, João X., Silva, Julia M.A., Balbino, Tereza C.L., Silva-Júnior, Edeildo F., Aquino, Thiago M., Mendonca-Junior, Francisco J.B., Marinho, Emmanuel S., Santos, Hélcio S., Lima, Clara Mariana Gonçalves, Obaidullah, Ahmad J., Bin Emran, Talha, Cunha, Francisco A.B., Menezes, Irwin R.A., Tintino, Saulo R., Coutinho, Henrique D.M.

“…Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms…”
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Current trends in designing antiviral agents against emerging and re-emerging RNA viruses by da Silva-Júnior, Edeildo F., Zhan, Peng

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Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity by Das, Suvankar, da Silva, Cristiane J., Silva, Marina de M., Dantas, Maria Dayanne de A., de Fátima, Ângelo, Góis Ruiz, Ana Lúcia T., da Silva, Cleiton M., de Carvalho, João Ernesto, Santos, Josué C.C., Figueiredo, Isis M., da Silva-Júnior, Edeildo F., de Aquino, Thiago M., de Araújo-Júnior, João X., Brahmachari, Goutam, Modolo, Luzia Valentina

“…[Display omitted] Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA…”
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The medicinal chemistry of Chikungunya virus by da Silva-Júnior, Edeildo F., Leoncini, Giovanni O., Rodrigues, Érica E.S., Aquino, Thiago M., Araújo-Júnior, João X.

“…[Display omitted] Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for…”
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Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives by França, Paulo H. B., Da Silva-Júnior, Edeildo F., Aquino, Pedro G. V., Santana, Antônio E. G., Ferro, Jamylle N. S., De Oliveira Barreto, Emiliano, Do Ó Pessoa, Cláudia, Meira, Assuero Silva, De Aquino, Thiago M., Alexandre-Moreira, Magna S., Schmitt, Martine, De Araújo-Júnior, João X.

“…Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic…”
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Evaluation of guanylhydrazone derivatives as inhibitors of Candida rugosa digestive lipase: Biological, biophysical, theoretical studies and biotechnological application by Santana, Camilla C., Silva-Júnior, Edeíldo F., Santos, João César N., Rodrigues, Érica E. da S., da Silva, Isabella M., Araújo-Júnior, João X., do Nascimento, Ticiano G., Oliveira Barbosa, Leandro A., Dornelas, Camila B., Figueiredo, Isis M., Santos, Josué Carinhanha C., Grillo, Luciano Aparecido M.

“…[Display omitted] •Five guanylhydrazone derivatives were evaluated as lipase inhibitors in vitro.•The derivative LQM11 was the most active with IC50 of…”
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Indole-3-guanylhydrazone hydrochloride mitigates long-term cognitive impairment in a neonatal sepsis model with involvement of MAPK and NFκB pathways by Heimfarth, Luana, Carvalho, Alexandra Maria Santos, Quintans, Jullyana de Souza Siqueira, Pereira, Erik Willyame Menezes, Lima, Natália Teles, Bezerra Carvalho, Mikaella Tuanny, Barreto, Rosana de Souza Siqueira, Moreira, José Cláudio Fonseca, da Silva-Júnior, Edeildo F., Schmitt, Martine, Bourguignon, Jean-Jacques, de Aquino, Thiago M., Araújo-Júnior, João X. de, Quintans-Júnior, Lucindo J.

“…Neonatal sepsis is defined as a systemic inflammatory response caused by a suspected or proven infection, occurring in the first month of life, and remains one…”
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Inclusion complex between β-cyclodextrin and hecogenin acetate produces superior analgesic effect in animal models for orofacial pain by Carvalho, Yasmim M.B.G., Menezes, Paula P., Sousa, Bruna M.H., Lima, Bruno S., Trindade, Igor A.S., Serafini, Mairim R., Pereira, Erik W.M., Rezende, Marilia M., Quintans, Jullyana S.S., Quintans-Júnior, Lucindo J., Nakamura, Celso V., Silva-Júnior, Edeildo F., Crispim, Alessandre C., Aquino, Thiago M., Araújo, Adriano A.S.

“…[Display omitted] Hecogenin acetate (HA) is a steroidal sapogenin-acetylated with pharmacological properties which have already been described in the…”
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Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents by Sandes, Silvia M.S., Heimfarth, Luana, Brito, Renan G., Santos, Priscila L., Gouveia, Daniele N., Carvalho, Alexandra M.S., Quintans, Jullyana S.S., da Silva-Júnior, Edeildo F., de Aquino, Thiago M., França, Paulo H.B., de Araújo-Júnior, João X., Albuquerque-Júnior, Ricardo L.C., Zengin, Gokhan, Schmitt, Martine, Bourguignon, Jean-Jacques, Quintans-Júnior, Lucindo J.

“…Indole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine. Mice were treated with LQM01…”
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Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme β-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease by Silva-Junior, Edeildo F, Barcellos Franca, Paulo H, Quintans-Junior, Lucindo J, Mendonca-Junior, Francisco J B, Scotti, Luciana, Scotti, Marcus T, de Aquino, Thiago M, de Araujo-Junior, Joao X

“…Alzheimer`s disease (AD) affects mainly elderly people over 60 years of age. Currently, there are more than 35 million people with this disease worldwide. The…”
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2-(Pyridin-4yl)benzothiazole and Its Benzimidazole-Analogue: Biophysical and in silico Studies on Their Interaction with Urease and in vitro Anti-Helicobacter pylori Activities by Pereira, Camila, de Lyra, Ana, Oliveira, Breno, Nascimento, Igor, da Silva-Júnior, Edeildo, de Aquino, Thiago, Sisto, Francesca, Figueiredo, Isis, Martins, Felipe, Modolo, Luzia, Santos, Josué, de Fátima, Ângelo

“…In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole…”
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Correlation between DNA/HSA-interactions and antimalarial activity of acridine derivatives: Proposing a possible mechanism of action by de M. Silva, Marina, Macedo, Taís S., Teixeira, Helena Mariana P., Moreira, Diogo Rodrigo M., Soares, Milena B.P., da C. Pereira, Ana Ligia, de L. Serafim, Vanessa, Mendonça-Júnior, Francisco J.B., do Carmo A. de Lima, Maria, de Moura, Ricardo O., da Silva-Júnior, Edeildo F., de Araújo-Júnior, João Xavier, de A. Dantas, Maria Dayanne, de O. O. Nascimento, Eduarda, Maciel, Thamilla Maria S., de Aquino, Thiago Mendonça, Figueiredo, Isis M., Santos, Josué C.C.

“…Acridines are considered an important class of compounds due to their wide variety of biological activities. In this work, we synthesized four acridine…”
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TNF-α Inhibitors from Natural Compounds: An Overview, CADD Approaches, and their Exploration for Anti-inflammatory Agents by Dos Santos Nascimento, Igor José, da Silva-Júnior, Edeildo Ferreira

“…Inflammation is a natural process that occurs in the organism in response to harmful external agents. Despite being considered beneficial, exaggerated cases…”
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Molecular Docking Studies Applied to a Dataset of Cruzain Inhibitors by da Silva-Junior, Edeildo Ferreira, Barcellos Franca, Paulo Henrique, Ribeiro, Frederico Favaro, Bezerra Mendonca-Junior, Francisco Jaime, Scotti, Luciana, Scotti, Marcus Tullius, de Aquino, Thiago Mendonca, de Araujo-Junior, Joao Xavier

“…Chagas' disease is one of the main causes of heart failure in developing countries. The disadvantages of current therapy include the undesirable side-effects,…”
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