Search Results - "Silva, Diana F"

The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson's Disease by Magalhães, João D, Esteves, Ana Raquel, Candeias, Emanuel, Silva, Diana F, Empadinhas, Nuno, Cardoso, Sandra Morais

“…Mitochondria play a key role in regulating host metabolism, immunity and cellular homeostasis. Remarkably, these organelles are proposed to have evolved from…”
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Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons by Silva, Diana F., Candeias, Emanuel, Esteves, A. Raquel, Magalhães, João D., Ferreira, I. Luísa, Nunes-Costa, Daniela, Rego, A. Cristina, Empadinhas, Nuno, Cardoso, Sandra M.

“…Background After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known etiology…”
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Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease by Fancellu, Gaia, Chand, Karam, Tomás, Daniel, Orlandini, Elisabetta, Piemontese, Luca, Silva, Diana F., Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia

“…Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the…”
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The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease by Santos, Daniel, Esteves, A. Raquel, Silva, Diana F., Januário, Cristina, Cardoso, Sandra M.

“…Accumulating data suggests that mitochondrial deficits may underline both sporadic and familial Parkinson’s disease (PD) neurodegenerative process. Impairment…”
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LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease by Esteves, A. Raquel, Silva, Diana F., Banha, Diogo, Candeias, Emanuel, Guedes, Beatriz, Cardoso, Sandra M.

“…Sporadic Parkinson's disease (sPD) is a complex multifactorial disorder which etiology remains elusive. Several mechanisms have been described to contribute to…”
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Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic by ARDUINO, Daniela M, RAQUEL ESTEVES, A, CORTES, Luisa, SILVA, Diana F, PATEL, Bindi, GRAZINA, Manuela, SWERDLOW, Russell H, OLIVEIRA, Catarina R, CARDOSO, Sandra M

“…Abnormal presence of autophagic vacuoles is evident in brains of patients with Parkinson's disease (PD), in contrast to the rare detection of autophagosomes in…”
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Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease by Fernandes, Tânia, Resende, Rosa, Silva, Diana F., Marques, Ana P., Santos, Armanda E., Cardoso, Sandra M., Domingues, M. Rosário, Moreira, Paula I., Pereira, Cláudia F.

“…Alzheimer’s disease (AD) is characterized by the accumulation of extracellular plaques composed by amyloid-β (Aβ) and intracellular neurofibrillary tangles of…”
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Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients by Marques, Ana P., Resende, Rosa, Silva, Diana F., Batista, Mariana, Pereira, Daniela, Wildenberg, Brigite, Morais, Sofia, Macedo, António, Pais, Cláudia, Melo, Joana B., Madeira, Nuno, Pereira, Cláudia F.

“…This study aims to evaluate whether mitochondrial changes occur in the early stages of bipolar disorder (BD). Using fibroblasts derived from BD patients and…”
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Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria by Esteves, A Raquel, Munoz-Pinto, Mário F, Nunes-Costa, Daniela, Candeias, Emanuel, Silva, Diana F, Magalhães, João D, Pereira-Santos, A Raquel, Ferreira, I Luisa, Alarico, Susana, Tiago, Igor, Empadinhas, Nuno, Cardoso, Sandra Morais

“…Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence…”
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Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases by Arduino, Daniela M, Esteves, A Raquel, Silva, Diana F F, Martins-Branco, Diogo, Santos, Daniel, Pimentel, Diana F Gomes, Cardoso, Sandra M

“…Cellular homeostasis relies on quality control systems so that damaged biologic structures are either repaired or degraded and entirely replaced by newly…”
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Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson’s disease by D. Magalhães, João, Candeias, Emanuel, Melo-Marques, Inês, Silva, Diana F., Esteves, A. Raquel, Empadinhas, Nuno, Cardoso, Sandra Morais

“…Parkinson’s disease (PD) is a multifactorial neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. In the prodromal…”
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Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease by Esteves, Ana R., Arduíno, Daniela M., Silva, Diana F., Viana, Sofia D., Pereira, Frederico C., Cardoso, Sandra M.

“…Alterations in microtubule-dependent transport, mitochondrial dysfunction, and autophagic pathology are involved in neurodegeneration observed in sporadic…”
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Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization by Costa, Marina, Josselin, Romane, Silva, Diana F., Cardoso, Sandra M., May, Nóra V., Chaves, Sílvia, Santos, M. Amélia

“…The intricate and multifactorial nature of Alzheimer's disease (AD) requires the development of compounds able to hit different pathophysiological targets,…”
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Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis by Branco, Diogo Martins, Arduino, Daniela M, Esteves, A Raquel, Silva, Diana F F, Cardoso, Sandra M, Oliveira, Catarina Resende

“…Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic…”
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Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines by Silva, Diana F, Selfridge, J Eva, Lu, Jianghua, E, Lezi, Roy, Nairita, Hutfles, Lewis, Burns, Jeffrey M, Michaelis, Elias K, Yan, ShiDu, Cardoso, Sandra M, Swerdlow, Russell H

“…Bioenergetic dysfunction occurs in Alzheimer's disease (AD) and mild cognitive impairment (MCI), a clinical syndrome that frequently precedes symptomatic AD…”
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The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease by Esteves, A. Raquel, Filipe, Filipa, Magalhães, João D., Silva, Diana F., Cardoso, Sandra M.

“…Macroautophagy impairment plays a key role in sporadic Alzheimer’s disease (sAD) neurodegenerative process. Nevertheless, the mechanism(s) that lead to a…”
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New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease by Keri, Rangappa S., Quintanova, Catarina, Chaves, Sílvia, Silva, Diana F., Cardoso, Sandra M., Santos, M. Amélia

“…Alzheimer's disease (AD) is a devastating age‐dependent neurodegenerative disorder. The main hallmarks are impairment of cholinergic system and accumulation in…”
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Multifunctional iron-chelators with protective roles against neurodegenerative diseases by Nunes, Andreia, Marques, Sérgio M, Quintanova, Catarina, Silva, Diana F, Cardoso, Sandra M, Chaves, Sílvia, Santos, M Amélia

“…The multifactorial nature of Alzheimer's disease (AD), and the absence of a disease modifying drug, makes the development of new multifunctional drugs an…”
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Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention by Silva, Diana F, Selfridge, J Eva, Lu, Jianghua, E, Lezi, Cardoso, Sandra M, Swerdlow, Russell H

“…Mitochondria from persons with Alzheimer's disease (AD) differ from those of age-matched control subjects. Differences in mitochondrial morphology and function…”
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Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway by Silva, Diana F F, Esteves, A Raquel, Arduino, Daniela M, Oliveira, Catarina R, Cardoso, Sandra M

“…Mitochondrial dysfunction is observed in Alzheimer's disease (AD) brain and peripheral tissues. Amyloid-β (Aβ) peptides are known to interact with several…”
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