Search Results - "Silva, Dahara Keyse Carvalho"
-
1
In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N -Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis
Published in Frontiers in pharmacology (16-12-2020)“…Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause…”
Get full text
Journal Article -
2
Molecular Hybridization Strategy on the Design, Synthesis, and Structural Characterization of Ferrocene- N -acyl Hydrazones as Immunomodulatory Agents
Published in Molecules (Basel, Switzerland) (30-11-2022)“…Immunomodulatory agents are widely used for the treatment of immune-mediated diseases, but the range of side effects of the available drugs makes necessary the…”
Get full text
Journal Article -
3
Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy
Published in Frontiers in cellular and infection microbiology (12-11-2021)“…Chagas disease is a parasitic infection caused by the intracellular protozoan . Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the…”
Get full text
Journal Article -
4
A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp
Published in Frontiers in pharmacology (22-03-2022)“…Leishmaniasis are endemic diseases caused by different species of intracellular parasites of the genus . Due to the high toxicity and drug resistance of…”
Get full text
Journal Article -
5
Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway
Published in Pharmaceuticals (Basel, Switzerland) (21-02-2024)“…Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it…”
Get full text
Journal Article -
6
Therapeutic Applications of Physalins: Powerful Natural Weapons
Published in Frontiers in pharmacology (05-04-2022)“…Physalins, or 16,24-cyclo-13,14-seco steroids, are compounds belonging to the class of withanolides that can be found in plants of Solanaceae family, mainly in…”
Get full text
Journal Article -
7
Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction
Published in International immunopharmacology (01-12-2018)“…Immunosuppressive drugs are widely used for the treatment of immune-mediated diseases and inflammation, but the toxicity and side effects of the available…”
Get full text
Journal Article -
8
Molecular Hybridization Strategy on the Design, Synthesis, and Structural Characterization of Ferrocene-IN/I-acyl Hydrazones as Immunomodulatory Agents
Published in Molecules (Basel, Switzerland) (01-11-2022)“…Immunomodulatory agents are widely used for the treatment of immune-mediated diseases, but the range of side effects of the available drugs makes necessary the…”
Get full text
Journal Article -
9
Betulinic acid derivative BA5, a dual NF-kB/calcineurin inhibitor, alleviates experimental shock and delayed hypersensitivity
Published in European journal of pharmacology (15-11-2017)“…Betulinic acid (BA) is a naturally occurring triterpenoid with several biological properties already described, including immunomodulatory activity. Here we…”
Get full text
Journal Article -
10
Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-?B Signaling Pathway
Published in Pharmaceuticals (Basel, Switzerland) (01-02-2024)“…Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it…”
Get full text
Journal Article