Stages of care for patients with chronic hepatitis C at a hospital in southern Brazil
Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseas...
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| Published in: | World journal of hepatology Vol. 15; no. 8; pp. 973 - 984 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Baishideng Publishing Group Inc
27-08-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseases. Despite the rising incidence of PSC, there is no proven medical therapy that can alter the natural history of the disease. While liver transplantation (LT) is the most effective approach for managing advanced liver disease caused by PSC, post-transplantation recurrence of PSC remains a challenge. Therefore, ongoing research aims to develop better therapies for PSC, and continued efforts are necessary to improve outcomes for patients with PSC. This article provides an overview of PSC’s pathogenesis, clinical presentation, and management options, including LT trends and future aspects. It also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with PSC. Additionally, the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is discussed. Ongoing research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author: Manoela Badinelli Vaucher, MD, Doctor, Department of Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245 Centro Histórico, Porto Alegre 90050-170, Rio Grande do Sul, Brazil. manuvaucher@hotmail.com Author contributions: Vaucher MB analyzed the data and wrote the manuscript; Silva CU performed the research; Varella IRS contributed to data analysis and helped perform the research; Kim AYS contributed analytic tools and reviewed the manuscript; and Kliemann DA designed the research study and reviewed the manuscript. |
| ISSN: | 1948-5182 1948-5182 |
| DOI: | 10.4254/wjh.v15.i8.973 |