Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert

Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. A total sample between 3856 and 4000 individuals. Questionnaires w...

Full description

Saved in:

Bibliographic Details
Published in:	Annals of hepatology Vol. 22; p. 100272
Main Authors:	Nunes, Jomar Diogo Costa, Silva, Diego Luz Felipe da, Fonseca, Lena Maria Barros, Felipe, Ilana Mirian Almeida, Ferreira, Beatriz Rossetti, Santana, Rodrigo de Carvalho, Martinelli, Ana de Lourdes Candolo, Silva, Antônio Augusto Moura da, Pinho, João Renato Rebello, Gouvêa, Michele Soares Gomes, Santos, Max Diego Cruz, Lima, Thais Feres Moreira, Albuquerque, Ingrid de Campos, Souza, Marinilde Teles, Moraes, Maria Josélia Diniz, Caldas, Arlene de Jesus Mendes, Souza, Letícia Alana Barros, Silva, Camila Maria Pinheiro de Mello e, Ferreira, Adalgisa de Souza Paiva
Format:	Journal Article
Language:	English
Published:	Mexico Elsevier España, S.L.U 01-05-2021 Elsevier
Subjects:	Health impact assessment Health policy Hepatitis B Health impact assessment Health policy Hepatitis B
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. A total sample between 3856 and 4000 individuals. Questionnaires were used to register sociodemographic characteristics and factors associated with transmission. Patients were tested for hepatitis B virus surface antigen (HBsAg), anti-hepatitis B core antigen (anti-HBc), and antibodies against hepatitis Delta virus (anti-HDV). Factors associated with HBV were detected by means of multivariate Poisson regression. Overall, 3983 subjects were included. Ninety-two of the participants were HBsAg-positive (2.30%, 95% CI 1.80–2.80), and anti-HBc was detected in 1535 (38.50%, 95% CI 37–40). The factors associated with the presence of anti-HBc were: (1) Municipality (P<0.001); Age (P<0.001); School education (P<0.001); Illicit drug use (P=0.001); non-HBV vaccine (P=0.041). Among the HBsAg carriers, eight were anti-HDV-positive (8.69%, 95% CI 2.90–14.40). The most frequent HBV genotype was D4. The only HDV genotype was HDV-8. HBV exhibited intermediate endemicity in the studied region. Traditional factors were associated with exposure to the virus. The presence of the HDV was confirmed. The most frequent HBV and HDV genotypes were unlike the ones currently described in Brazil.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1665-2681 2659-5982
DOI:	10.1016/j.aohep.2020.09.016