Permissive or Trophic Enteral Nutrition and Full Enteral Nutrition Had Similar Effects on Clinical Outcomes in Intensive Care: A Systematic Review of Randomized Clinical Trials

Permissive or Trophic Enteral Nutrition and Full Enteral Nutrition Had Similar Effects on Clinical Outcomes in Intensive Care: A Systematic Review of Randomized Clinical Trials

The aim of this study was to systematically review the effect of permissive underfeeding/trophic feeding on the clinical outcomes of critically ill patients. A systematic review of randomized clinical trials to evaluate the mortality, length of stay, and mechanical ventilation duration in patients r...

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Bibliographic Details
Published in:Nutrition in clinical practice Vol. 33; no. 3; pp. 388 - 396
Main Authors: Silva, Camila F. A., Vasconcelos, Simone G., da Silva, Thales A., Silva, Flávia M.
Format: Journal Article
Language:English
Published: United States 01-06-2018
Subjects:
Critical Care
critical illness
Critical Illness - therapy
Enteral Nutrition
Humans
intensive care unit
Length of Stay
Nursing
Nutritional Status
nutritional support
permissive underfeeding
Randomized Controlled Trials as Topic
Respiration, Artificial
Treatment Outcome
enteral nutrition
intensive care unit
nutritional support
critical illness
permissive underfeeding
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Summary:The aim of this study was to systematically review the effect of permissive underfeeding/trophic feeding on the clinical outcomes of critically ill patients. A systematic review of randomized clinical trials to evaluate the mortality, length of stay, and mechanical ventilation duration in patients randomized to either hypocaloric or full‐energy enteral nutrition was performed. Data sources included PubMed and Scopus and the reference lists of the articles retrieved. Two independent reviewers participated in all phases of this systematic review as proposed by the Cochrane Handbook, and the review was reported according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. A total of 7 randomized clinical trials that included a total of 1,717 patients were reviewed. Intensive care unit length of stay and mechanical ventilation duration were not statistically different between the intervention and control groups in all randomized clinical trials, and mortality rate was also not different between the groups. In conclusion, hypocaloric enteral nutrition had no significantly different effects on morbidity and mortality in critically ill patients when compared with full‐energy nutrition. It is still necessary to determine the safety of this intervention in this group of patients, the optimal amount of energy provided, and the duration of this therapy.
Bibliography:Conflict of interest: None declared.
Financial disclosure: None declared.
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ISSN:0884-5336
1941-2452
DOI:10.1002/ncp.10001