Search Results - "Silva, Bruno F.B."

Structural transitions induced by shear flow and temperature variation in a nonionic surfactant/water system by Gentile, Luigi, Silva, Bruno F.B., Balog, Sandor, Mortensen, Kell, Olsson, Ulf

“…[Display omitted] ► Dynamic phase diagram of the 40wt.% C16E4/D2O system. ► Rheo-SANS, rheo-SALS, and rheology elucidate the shear-induced transitions. ►…”
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Uptake and transfection efficiency of PEGylated cationic liposome–DNA complexes with and without RGD-tagging by Majzoub, Ramsey N, Chan, Chia-Ling, Ewert, Kai K, Silva, Bruno F.B, Liang, Keng S, Jacovetty, Erica L, Carragher, Bridget, Potter, Clinton S, Safinya, Cyrus R

“…Abstract Steric stabilization of cationic liposome–DNA (CL–DNA) complexes is required for in vivo applications such as gene therapy. PEGylation (PEG:…”
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Enhanced magnetic microcytometer with 3D flow focusing for cell enumeration by Chícharo, Alexandre, Martins, Marco, Barnsley, Lester C, Taouallah, Amal, Fernandes, João, Silva, Bruno F B, Cardoso, Susana, Diéguez, Lorena, Espiña, Begoña, Freitas, Paulo P

“…We report the design and characterization of a lateral and vertical hydrodynamic focusing feature for whole cell detection on a miniaturized flow cytometer…”
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Nematic Director Reorientation at Solid and Liquid Interfaces under Flow: SAXS Studies in a Microfluidic Device by Silva, Bruno F. B, Zepeda-Rosales, Miguel, Venkateswaran, Neeraja, Fletcher, Bretton J, Carter, Lester G, Matsui, Tsutomu, Weiss, Thomas M, Han, Jun, Li, Youli, Olsson, Ulf, Safinya, Cyrus R

“…In this work we investigate the interplay between flow and boundary condition effects on the orientation field of a thermotropic nematic liquid crystal under…”
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Chain length mismatch and packing effects on the thermotropic phase behavior of salt-free catanionic surfactants by Matos, Marta R.A., Silva, Bruno F.B., Marques, Eduardo F.

“…[Display omitted] •Chain length mismatch in catanionic surfactants induces rich mesomorphism.•Unexpected trends in phase transition temperatures and enthalpies…”
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Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of rapamycin by Ramalheiro, Ana, Paris, Juan L., Silva, Bruno F.B., Pires, Liliana R.

“…[Display omitted] In this study, we developed a system for the transdermal delivery and controlled release of the hydrophobic immunosuppressive drug rapamycin,…”
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Recent advances in multiple emulsions and their application as templates by Silva, Bruno F.B., Rodríguez-Abreu, Carlos, Vilanova, Neus

“…We review recent developments on the preparation of multiple emulsions and their applications as templates for material fabrication. Emphasis is placed on…”
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Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment by Gaspar, Ricardo, Coelho, Filipe, Silva, Bruno F B

“…Cancer is an extremely complex disease, typically caused by mutations in cancer-critical genes. By delivering therapeutic nucleic acids (NAs) to patients, gene…”
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Stability Criterion for the Assembly of Core–Shell Lipid–Polymer–Nucleic Acid Nanoparticles by Paris, Juan L., Gaspar, Ricardo, Coelho, Filipe, De Beule, Pieter A. A., Silva, Bruno F. B.

“…Hybrid core–shell lipid–polycation–nucleic acid nanoparticles (LPNPs) provide unique delivery strategies for nonviral gene therapeutics. Since LPNPs consist of…”
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Rhamnolipids-based nanostructured lipid carriers: Effect of lipid phase on physicochemical properties and stability by Azevedo, Maria A., Cerqueira, Miguel A., Fuciños, Pablo, Silva, Bruno F.B., Teixeira, José A., Pastrana, Lorenzo

“…•Rhamnolipids were used for the production of nanostructured lipid carriers (NLCs).•The ratio between solid and liquid lipid influence the properties of…”
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Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation by Krupnik, Leonard, Avaro, Jonathan, Liebi, Marianne, Anaraki, Neda Iranpour, Kohlbrecher, Joachim, Sologubenko, Alla, Handschin, Stephan, Rzepiela, Andrzej J., Appel, Christian, Totu, Tiberiu, Blanchet, Clement E., Alston, Amy E. Barton, Digigow, Reinaldo, Philipp, Erik, Flühmann, Beat, Silva, Bruno F.B., Neels, Antonia, Wick, Peter

“…Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions…”
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Influence of the media ionic strength on the formation and in vitro biological performance of polycation-DNA complexes by Coelho, Filipe, Botelho, Claudia, Paris, Juan L., Marques, Eduardo F., Silva, Bruno F.B.

“…•Polyplex formation in physiological buffer is pathway-dependent.•Polyplex size and colloidal stability depend on ionic strength during…”
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Cationic lipid-based formulations for encapsulation and delivery of anti-EFG1 2′ OMethylRNA oligomer by Araújo, Daniela, Gaspar, Ricardo, Mil-Homens, Dalila, Henriques, Mariana, Silva, Bruno F B, Silva, Sónia

“…Abstract The effective protection and delivery of antisense oligomers to its site of action is a challenge without an optimal strategy. Some of the most…”
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Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P)H multi-photon fluorescence lifetime imaging by Faria, Ana R., Silvestre, Oscar F., Maibohm, Christian, Adão, Ricardo M. R., Silva, Bruno F. B., Nieder, Jana B.

“…Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen species. Here, for the first time, we encapsulate the poorly…”
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Unravelling a Mechanism of Action for a Cecropin A‑Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks by Silva, Tânia, Claro, Bárbara, Silva, Bruno F. B, Vale, Nuno, Gomes, Paula, Gomes, Maria Salomé, Funari, Sérgio S, Teixeira, José, Uhríková, Daniela, Bastos, Margarida

“…An understanding of the mechanism of action of antimicrobial peptides is fundamental to the development of new and more active antibiotics. In the present…”
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pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy by Vieira, Ana Mg, Silvestre, Oscar F, Silva, Bruno Fb, Ferreira, Celso Jo, Lopes, Ivo, Gomes, Andreia C, Espiña, Begoña, Sárria, Marisa P

“…Yessotoxin (YTX), a marine-derived drug, was encapsulated in PEGylated pH-sensitive nanoliposomes, covalently functionalized (strategy I) with SDF-1α and by…”
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In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture by Paris, Juan L, Coelho, Filipe, Teixeira, Alexandra, Diéguez, Lorena, Silva, Bruno F B, Abalde-Cela, Sara

“…Complexes combining nucleic acids with lipids and polymers (lipopolyplexes) show great promise for gene therapy since they enable compositional, physical and…”
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Sustained Release of a Streptococcus pneumoniae Endolysin from Liposomes for Potential Otitis Media Treatment by Silva, Maria Daniela, Paris, Juan L, Gama, Francisco Miguel, Silva, Bruno F. B, Sillankorva, Sanna

“…Local delivery of antimicrobials for otitis media treatment would maximize therapeutic efficacy while minimizing side effects. However, drug transport across…”
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PEGylated cationic liposome–DNA complexation in brine is pathway-dependent by Silva, Bruno F.B., Majzoub, Ramsey N., Chan, Chia-Ling, Li, Youli, Olsson, Ulf, Safinya, Cyrus R.

“…Cationic liposome–DNA (CL–DNA) complexes, are regarded as promising materials for safe and efficient delivery of genes for therapeutical applications. In order…”
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Fluorescence microscopy colocalization of lipid–nucleic acid nanoparticles with wildtype and mutant Rab5–GFP: A platform for investigating early endosomal events by Majzoub, Ramsey N., Chan, Chia-Ling, Ewert, Kai K., Silva, Bruno F.B., Liang, Keng S., Safinya, Cyrus R.

“…Endosomal entrapment is known to be a major bottleneck to successful cytoplasmic delivery of nucleic acids (NAs) using cationic liposome–NA nanoparticles…”
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