A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. In this blind, randomized controlled clinica...

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Bibliographic Details
Published in:	Revista brasileira de psiquiatria Vol. 37; no. 4; pp. 271 - 279
Main Authors:	Silva, Bruna Andrade E, Cassilhas, Ricardo C, Attux, Cecília, Cordeiro, Quirino, Gadelha, André L, Telles, Bruno A, Bressan, Rodrigo A, Ferreira, Francine N, Rodstein, Paulo H, Daltio, Claudiane S, Tufik, Sérgio, de Mello, Marco T
Format:	Journal Article
Language:	English
Published:	Brazil Associação Brasileira de Psiquiatria 01-10-2015 Associação Brasileira de Psiquiatria (ABP)
Subjects:	Adolescent Adult Analysis of Variance Antipsychotic Agents - therapeutic use BDNF Brain-Derived Neurotrophic Factor - blood concurrent exercise Exercise Therapy - methods Humans IGF-1 IGFBP-3 Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Male Middle Aged Muscle Strength - physiology Physical exercise PSYCHIATRY Quality of Life resistance exercise Resistance Training - methods schizophrenia Schizophrenia - physiopathology Schizophrenia - rehabilitation Single-Blind Method Time Factors Treatment Outcome Young Adult Physical exercise concurrent exercise IGFBP-3 BDNF IGF-1 schizophrenia resistance exercise
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Summary:	To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables were assessed. A significant time-by-group interaction was found for the RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, significant improvements on negative symptoms (p = 0.027), on the role-physical domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM test (p = 0.040) were observed in the RESEX group. No changes were observed for the other variables investigated. In this sample of patients with schizophrenia, 20 weeks of resistance or concurrent exercise program improved disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23
ISSN:	1516-4446 1809-452X 1809-452X
DOI:	10.1590/1516-4446-2014-1595