Effects of exercise training on papain-induced pulmonary emphysema in Wistar rats

Departments of 1 Medicine and 2 Pathology, Faculty of Medicine, University of São Paulo, and 3 Department of Physiotherapy, UNICID, University City of São Paulo, São Paulo, Brazil Submitted 6 January 2005 ; accepted in final form 29 August 2005 The purpose of the present study was to evaluate the ro...

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Published in:	Journal of applied physiology (1985) Vol. 100; no. 1; pp. 281 - 285
Main Authors:	Flo, Claudia, Lopes, Fernanda D. T. Q. S, Kasahara, David I, Silva, Anna Cecilia D, Jesus, Rita C. C, Rivero, Dolores H. R. F, Saldiva, Paulo H. N, Martins, Milton A, Jacob-Filho, Wilson
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Am Physiological Soc 01-01-2006 American Physiological Society
Subjects:	Airway Resistance Animals Biological and medical sciences Disease Models, Animal Emphysema Emphysema - chemically induced Emphysema - physiopathology Exercise Fundamental and applied biological sciences. Psychology Lung Compliance Male Papain Physical Conditioning, Animal - methods Physical Exertion Pulmonary arteries Rats Rats, Wistar Rodents Physical exercise Lung disease Physical training Rat Respiratory disease Enzyme Chronic disease Cysteine endopeptidases Rodentia experimental emphysema Papain Respiratory system Peptidases Vertebrata Mammalia Bronchus disease Hydrolases Obstructive pulmonary disease Emphysema chronic obstructive pulmonary disease
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Summary:	Departments of 1 Medicine and 2 Pathology, Faculty of Medicine, University of São Paulo, and 3 Department of Physiotherapy, UNICID, University City of São Paulo, São Paulo, Brazil Submitted 6 January 2005 ; accepted in final form 29 August 2005 The purpose of the present study was to evaluate the role of exercise training on the development of papain-induced emphysema in rats. Our hypothesis was that the increase in pulmonary tissue stretching associated with exercise could increase the severity of a protease-induced emphysema. Wistar rats were randomly assigned to four groups ( n = 10 for each group) that received, respectively, intratracheal infusion of papain (6 mg in 1 ml of 0.9% NaCl) or vehicle and were submitted or not to a protocol of exercise on a treadmill. Rats exercised at 13.3 m/min, 6 days/wk, for 9 wk (increasing exercise time, from 10 to 35 min). We measured respiratory system elastance and resistance, the size and weight of the heart, and pulmonary mean linear intercept (Lm). After 9 wk of exercise training, there were no differences in respiratory system resistance and elastance values among the four experimental groups. Volume of the heart was significantly greater in rats submitted to exercise training ( P = 0.007) compared with sedentary rats due to increases in volumes of both right and left cardiac chambers. Lm was significantly greater in rats that received papain compared with saline-infused rats ( P = 0.025). Surprisingly, this was true, even though there was no significant decrease in elastance, possibly due to connective tissue remodeling. However, Lm was significantly greater in papain + exercise rats compared with rats that received papain and were not submitted to exercise. We conclude that exercise training can increase alveolar damage induced by papain infusion. experimental emphysema; papain; chronic obstructive pulmonary disease Address for reprint requests and other correspondence: M. A. Martins, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de Sao Paulo, Av. Dr. Arnaldo 455, Sala 1216, 01246-903 São Paulo SP, Brazil (e-mail: mmartins{at}usp.br )
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	8750-7587 1522-1601
DOI:	10.1152/japplphysiol.00024.2005