Circadian Rhythm Dysregulation and Leukemia Development: The Role of Clock Genes as Promising Biomarkers

The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to the external environment in order to maintain internal homeostasis. For the functioning of the CC, the clock genes (CG) act in different metabolic pathways through the clock-contr...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 15; p. 8212
Main Authors:	Sanford, Ana Beatriz Aguiar, da Cunha, Leidivan Sousa, Machado, Caio Bezerra, de Pinho Pessoa, Flávia Melo Cunha, Silva, Abigail Nayara dos Santos, Ribeiro, Rodrigo Monteiro, Moreira, Fabiano Cordeiro, de Moraes Filho, Manoel Odorico, de Moraes, Maria Elisabete Amaral, de Souza, Lucas Eduardo Botelho, Khayat, André Salim, Moreira-Nunes, Caroline Aquino
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-08-2022 MDPI
Subjects:	Biological clocks Biomarkers Bone marrow Cell cycle Cell division Cell growth Cell proliferation Circadian rhythm Circadian rhythms clock genes Cyclin-dependent kinases Deregulation Disease Gene expression Gene regulation Genes Hematopoietic stem cells Homeostasis Insulin resistance Kinases Leukemia Lymphoma Metabolic disorders Metabolic pathways Oscillations Physiology Proteins Review Shift work Skin cancer Stem cells
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to the external environment in order to maintain internal homeostasis. For the functioning of the CC, the clock genes (CG) act in different metabolic pathways through the clock-controlled genes (CCG), providing cellular regulation. The CC’s interruption can result in the development of different diseases, such as neurodegenerative and metabolic disorders, as well as cancer. Leukemias correspond to a group of malignancies of the blood and bone marrow that occur when alterations in normal cellular regulatory processes cause the uncontrolled proliferation of hematopoietic stem cells. This review aimed to associate a deregulated CC with the manifestation of leukemia, looking for possible pathways involving CG and their possible role as leukemic biomarkers.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23158212