Search Results - "Silm, Katlin"
-
1
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry
Published in Nature communications (23-01-2018)“…Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms…”
Get full text
Journal Article -
2
Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles
Published in The Journal of neuroscience (12-04-2017)“…The atypical vesicular glutamate transporter type 3 (VGLUT3) is expressed by subpopulations of neurons using acetylcholine, GABA, or serotonin as…”
Get full text
Journal Article -
3
Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties
Published in Neuron (Cambridge, Mass.) (22-05-2019)“…In contrast to temporal coding by synaptically acting neurotransmitters such as glutamate, neuromodulators such as monoamines signal changes in firing rate…”
Get full text
Journal Article -
4
A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency
Published in eLife (30-10-2019)“…Glutamate secretion at excitatory synapses is tightly regulated to allow for the precise tuning of synaptic strength. Vesicular Glutamate Transporters (VGLUT)…”
Get full text
Journal Article -
5
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes
Published in The Journal of neuroscience (06-03-2013)“…The concept of a tripartite synapse including a presynaptic terminal, a postsynaptic spine, and an astrocytic process that responds to neuronal activity by…”
Get full text
Journal Article -
6
Role of adaptor protein complexes in generating functionally distinct synaptic vesicle pools
Published in The Journal of physiology (21-07-2024)“…The synaptic vesicle (SV) cycle ensures the release of neurotransmitters and the replenishment of SVs to sustain neuronal activity. Multiple endocytosis and…”
Get full text
Journal Article -
7
Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism
Published in Neuron (Cambridge, Mass.) (18-05-2016)“…The quantal nature of synaptic transmission requires a mechanism to transport neurotransmitter into synaptic vesicles without promoting non-vesicular efflux…”
Get full text
Journal Article -
8
A role for vesicular glutamate transporter 1 in synaptic vesicle clustering and mobility
Published in The European journal of neuroscience (01-05-2013)“…Synaptic vesicles (SVs) from excitatory synapses carry vesicular glutamate transporters (VGLUTs) that fill the vesicles with neurotransmitter. Although the…”
Get full text
Journal Article -
9
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine
Published in Proceedings of the National Academy of Sciences - PNAS (17-10-2023)“…The burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. At many synapses, however, high firing…”
Get full text
Journal Article -
10
One Cycle Fuels Another: The Energetics of Neurotransmitter Release
Published in Neuron (Cambridge, Mass.) (08-02-2017)“…In this issue of Neuron, Ashrafi et al. (2017) show that activity induces translocation of the insulin-regulated glucose transporter GLUT4 to the plasma…”
Get full text
Journal Article -
11
Is Aspartate an Excitatory Neurotransmitter?
Published in The Journal of neuroscience (15-07-2015)“…Recent evidence has resurrected the idea that the amino acid aspartate, a selective NMDA receptor agonist, is a neurotransmitter. Using a mouse that lacks the…”
Get full text
Journal Article -
12
A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons
Published in Neuropharmacology (15-03-2017)“…Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes,…”
Get full text
Journal Article -
13
In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice
Published in The Journal of neuroscience (26-10-2011)“…The vesicular glutamate transporter VGLUT1 loads synaptic vesicles with the neurotransmitter glutamate and thereby determines glutamate release at many…”
Get full text
Journal Article -
14
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice
Published in The Journal of neuroscience (26-10-2011)“…The vesicular glutamate transporter VGLUT1 loads synaptic vesicles with the neurotransmitter glutamate and thereby determines glutamate release at many…”
Get full text
Journal Article