Search Results - "Silletti, J"

Differential Localization of Rho GTPases in Live Cells: Regulation by Hypervariable Regions and RhoGDI Binding by Michaelson, David, Silletti, Joseph, Murphy, Gretchen, D'Eustachio, Peter, Rush, Mark, Philips, Mark R.

“…Determinants of membrane targeting of Rho proteins were investigated in live cells with green fluorescent fusion proteins expressed with or without Rhoguanine…”
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Ras signalling on the endoplasmic reticulum and the Golgi by Philips, Mark R, Chiu, Vi K, Bivona, Trever, Hach, Angela, Sajous, J. Bernard, Silletti, Joseph, Wiener, Heidi, Johnson, Ronald L, Cox, Adrienne D

“…Current models evoke the plasma membrane (PM) as the exclusive platform from which Ras regulates signalling. We developed a fluorescent probe that reports…”
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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi by Choy, E, Chiu, V K, Silletti, J, Feoktistov, M, Morimoto, T, Michaelson, D, Ivanov, I E, Philips, M R

“…We show that Nras is transiently localized in the Golgi prior to the plasma membrane (PM). Moreover, green fluorescent protein (GFP)-tagged Nras illuminated…”
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Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases by Michaelson, David, Ali, Wasif, Chiu, Vi K, Bergo, Martin, Silletti, Joseph, Wright, Latasha, Young, Stephen G, Philips, Mark

“…The CAAX motif at the C terminus of most monomeric GTPases is required for membrane targeting because it signals for a series of three posttranslational…”
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Rap1 Up-Regulation and Activation on Plasma Membrane Regulates T Cell Adhesion by Bivona, Trever G., Wiener, Heidi H., Ahearn, Ian M., Silletti, Joseph, Chiu, Vi K., Philips, Mark R.

“…Rap1 and Ras are closely related GTPases that share some effectors but have distinct functions. We studied the subcellular localization of Rap1 and its sites…”
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Carboxyl Methylation of Ras Regulates Membrane Targeting and Effector Engagement by Chiu, Vi K., Silletti, Joseph, Dinsell, Victoria, Wiener, Heidi, Loukeris, Kristina, Ou, Guoming, Philips, Mark R., Pillinger, Michael H.

“…Post-translational modification of Ras proteins includes prenylcysteine-directed carboxyl methylation. Because Ras participates in Erk activation by epidermal…”
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