Search Results - "Sillence, Martin N"

The cresty neck score is an independent predictor of insulin dysregulation in ponies by Fitzgerald, Danielle M, Anderson, Stephen T, Sillence, Martin N, de Laat, Melody A

“…Generalized obesity, regional adiposity, hyperinsulinemia and hypertriglyceridemia are all potential indicators of equine metabolic syndrome (EMS). This study…”
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Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas by Galinelli, Nicolas C, Bamford, Nicholas J, de Laat, Melody A, Sillence, Martin N, Harris, Patricia A, Bailey, Simon R

“…Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin resistance and is associated with increased risk of laminitis…”
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Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis by Laat, Melody A., Sillence, Martin N., Reiche, Dania B.

“…Background Equine endocrinopathic laminitis is common and can be associated with an underlying endocrinopathy, such as equine metabolic syndrome (EMS),…”
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Incidence and risk factors for recurrence of endocrinopathic laminitis in horses by Laat, Melody A., Reiche, Dania B., Sillence, Martin N., McGree, James M.

“…Background Endocrinopathic laminitis is common in horses and ponies, but the recurrence rate of the disease is poorly defined. Objectives To determine the…”
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Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses by Rahnama, Samira, Vathsangam, Niveditha, Spence, Robert, Medina-Torres, Carlos E, Pollitt, Christopher C, de Laat, Melody A, Bailey, Simon R, Sillence, Martin N

“…Currently, there are no registered veterinary drugs for the treatment of endocrinopathic equine laminitis, and although this form of the disease is known to be…”
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Insulin and incretin responses to grazing in insulin‐dysregulated and healthy ponies by Fitzgerald, Danielle M., Walsh, Donald M., Sillence, Martin N., Pollitt, Christopher C., Laat, Melody A.

“…Background Supraphysiological insulin and incretin responses to a cereal‐based diet have been described in horses and ponies with insulin dysregulation (ID)…”
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Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies by Asplin, Katie E., Sillence, Martin N., Pollitt, Christopher C., McGowan, Catherine M.

“…The purpose of this study was to determine the effects of prolonged administration of insulin, whilst maintaining normal glucose concentrations, on hoof…”
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Carbohydrate pellets to assess insulin dysregulation in horses by Laat, Melody A., Warnken, Tobias, Delarocque, Julien, Reiche, Dania B., Grob, Anne J., Feige, Karsten, Carslake, Harry B., Durham, Andy E., Sillence, Martin N., Thane, Kristen E., Frank, Nicholas, Brojer, Johan, Lindase, Sanna, Sonntag, Johanna

“…Background A glycemic challenge test is used for the diagnosis of insulin dysregulation (ID) in horses and ponies. Different forms of the test exist where the…”
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An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis by de Laat, Melody A, Spence, Robert J, Sillence, Martin N, Pollitt, Christopher C

“…Equine laminitis is a disease of the digital epidermal lamellae typified by epidermal cell proliferation and structural collapse. Most commonly the disease is…”
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Metabolic profile distinguishes laminitis-susceptible and -resistant ponies before and after feeding a high sugar diet by Delarocque, Julien, Reiche, Dania B, Meier, Alexandra D, Warnken, Tobias, Feige, Karsten, Sillence, Martin N

“…Insulin dysregulation (ID) is a key risk factor for equine endocrinopathic laminitis, but in many cases ID can only be assessed accurately using dynamic tests…”
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The effect of different grazing conditions on the insulin and incretin response to the oral glucose test in ponies by Fitzgerald, Danielle M, Pollitt, Christopher C, Walsh, Donald M, Sillence, Martin N, de Laat, Melody A

“…The oral glucose test (OGT) is a useful tool for diagnosing insulin dysregulation (ID) and is somewhat repeatable in ponies under consistent management. This…”
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A "modified Obel" method for the severity scoring of (endocrinopathic) equine laminitis by Meier, Alexandra, de Laat, Melody, Pollitt, Christopher, Walsh, Donald, McGree, James, Reiche, Dania B, von Salis-Soglio, Marcella, Wells-Smith, Luke, Mengeler, Ulrich, Mesa Salas, Daniel, Droegemueller, Susanne, Sillence, Martin N

“…Laminitis is a common equine disease characterized by foot pain, and is commonly diagnosed using a five-grade Obel system developed in 1948 using…”
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Equine glucagon-like peptide-1 receptor physiology by Kheder, Murad H, Bailey, Simon R, Dudley, Kevin J, Sillence, Martin N, de Laat, Melody A

“…Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations…”
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β2‐Agonist administration reverses muscle wasting and improves muscle function in aged rats by Ryall, James G., Plant, David R., Gregorevic, Paul, Sillence, Martin N., Lynch, Gordon S.

“…The β2‐adrenoceptor agonist (β2‐agonist) fenoterol has potent anabolic effects on rat skeletal muscle. We conducted an extensive dose–response study to…”
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Associations between feeding and glucagon‐like peptide‐2 in healthy ponies by Sibthorpe, Poppy E. M., Fitzgerald, Danielle M., Sillence, Martin N., Laat, Melody A.

“…Background Gastrointestinal peptides, such as glucagon‐like peptide‐2 (GLP‐2), could play a direct role in the development of equine hyperinsulinaemia…”
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A starch-rich treat affects enteroinsular responses in ponies by Sibthorpe, Poppy E. M., Fitzgerald, Danielle M., Chen, Lan, Sillence, Martin N., de Laat, Melody A.

“…Abstract OBJECTIVE To determine the effect of a starch-rich treat, added to the daily diet of ponies for 10 days, on enteroinsular responses to meal…”
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The effect of diet change and insulin dysregulation on the faecal microbiome of ponies by Fitzgerald, Danielle M, Spence, Robert J, Stewart, Zachary K, Prentis, Peter J, Sillence, Martin N, de Laat, Melody A

“…The equine microbiome can change in response to dietary alteration and may play a role in insulin dysregulation. The aim of this study was to determine the…”
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Association between insulin dysregulation and adrenocorticotropic hormone in aged horses and ponies with no clinical signs of pituitary pars intermedia dysfunction by Li, Fang I, Spence, Robert J, de Laat, Melody A, Harris, Patricia A, Sonntag, Johanna, Menzies-Gow, Nicola J, Durham, Andy E, Bailey, Simon R, Sillence, Martin N

“…High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may…”
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Expression of the GCG gene and secretion of active glucagon‐like peptide‐1 varies along the length of intestinal tract in horses by Fitzgerald, Danielle M., Cash, Christina M., Dudley, Kevin J., Sibthorpe, Poppy E. M., Sillence, Martin N., Laat, Melody A.

“…Background Active glucagon‐like peptide‐1 (aGLP‐1) has been implicated in the pathogenesis of equine insulin dysregulation (ID), but its role is unclear…”
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Physiological and metabolic effects of short-term dopamine reduction in healthy horses using a tyrosine hydroxylase inhibitor (alpha-methyl-para-tyrosine) by Galinelli, Nicolas C., Bamford, Nicholas J., Erdody, Madison L., Warnken, Tobias, de Laat, Melody A., Sillence, Martin N., Harris, Patricia A., Bailey, Simon R.

“…•Plasma dopamine concentration was reduced after AMPT administration.•AMPT induced a spike in plasma prolactin, indicating central reduction of dopamine.•No…”
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