Search Results - "Sillence, M M"

Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation by de Laat, M A, McGree, J M, Sillence, M N

“…Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often…”
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Diagnosis of equine endocrinopathies: The value of measuring blood glucose during an oral glucose test by de Laat, M.A., Sillence, M.N.

“…Blood glucose concentration is often measured during an oral glucose test (OGT), but is not thought to aid in diagnosing insulin dysregulation (ID) or…”
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The repeatability of an oral glucose test in ponies by de Laat, M. A., Sillence, M. N.

“…Summary Reasons for performing study Insulin dysregulation can be difficult to diagnose from basal insulin and glucose concentrations, so a field‐based oral…”
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Equine laminitis: Induced by 48 h hyperinsulinaemia in Standardbred horses by De Laat, M.A, McGowan, C.M, Sillence, M.N, Pollitt, C.C

“…Summary Reasons for performing study: Hyperinsulinaemia is known to induce laminitis experimentally in healthy ponies with no history of the condition. Horses…”
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The oral glucose test predicts laminitis risk in ponies fed a diet high in nonstructural carbohydrates by Meier, A.D., de Laat, M.A., Reiche, D.B., Pollitt, C.C., Walsh, D.M., McGree, J.M., Sillence, M.N.

“…The aim of this study was to investigate the relationship between laminitis development in ponies and insulin/glucose concentrations in response to the oral…”
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Glucagon‐like peptide‐2: A potential role in equine insulin dysregulation by de Laat, M. A., Fitzgerald, D. M., Sillence, M. N., Spence, R. J.

“…Summary Background Equine insulin dysregulation (ID) is a common and poorly understood disorder that increases the risk of laminitis. Recent data show that the…”
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Studies in vitro of equine intestinal glucagon-like peptide-2 secretion by Sibthorpe, P.E.M., Fitzgerald, D.M., Sillence, M.N., de Laat, M.A.

“…•GLP-2 secretion was higher from the jejunum and ileum, compared to the duodenum.•GLP-2 secretion was responsive to glucose in the jejunum.•GLP-2 secretion was…”
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The application of a new laminitis scoring method to model the rate and pattern of improvement from equine endocrinopathic laminitis in a clinical setting by Meier, A, McGree, J, Klee, R, Preuß, J, Reiche, D, de Laat, M, Sillence, M

“…Endocrinopathic, or hyperinsulinaemia-associated laminitis (HAL) is a common and debilitating equine foot disease, and although no pharmacological treatments…”
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Sustained, Low‐Intensity Exercise Achieved by a Dynamic Feeding System Decreases Body Fat in Ponies by Laat, M.A., Hampson, B.A., Sillence, M.N., Pollitt, C.C.

“…Background Obesity in horses is increasing in prevalence and can be associated with insulin insensitivity and laminitis. Current treatment strategies for…”
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Glucagon-like peptide-1, insulin-like growth factor-1, and adiponectin in insulin-dysregulated ponies: effects of feeding a high nonstructural carbohydrate diet and association with prospective laminitis by Meier, A.D., de Laat, M.A., Reiche, D.B., Sillence, M.N.

“…Endocrinopathic laminitis, related to equine metabolic syndrome and insulin dysregulation, causes marked pain and suffering in horses and represents a…”
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The equine glucose-dependent insulinotropic polypeptide receptor: A potential therapeutic target for insulin dysregulation by Kheder, M H, Sillence, M N, Bryant, L M, de Laat, M A

“…Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent…”
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The equine glucose-dependent insulinotropic polypeptide receptor: A potential therapeutic target for insulin dysregulation by Kheder, M H, Sillence, M N, Bryant, L M, de Laat, M A

“…Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent…”
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The effect of oral and intravenous dextrose on C-peptide secretion in ponies by de Laat, M A, van Haeften, J J, Sillence, M N

“…Managing equine hyperinsulinemia is crucial for preventing laminitis, but our understanding of the mechanisms involved in insulin dysregulation in this species…”
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Technologies for the control of fat and lean deposition in livestock by Sillence, M.N.

“…When the ratio of lean to fat deposition is improved, so is feed conversion efficiency. Net benefits may include lower production costs, better product…”
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The efficacy and safety of velagliflozin over 16 weeks as a treatment for insulin dysregulation in ponies by Meier, A, de Laat, M, Reiche, D, Fitzgerald, D, Sillence, M

“…A previous six-week (wk) study demonstrated the potential of the sodium-glucose linked transport inhibitor velagliflozin as a novel treatment for equine…”
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Effects of insulin on IGF-1 receptors in equine lamellar tissue in vitro by Rahnama, S., Spence, R., Vathsangam, N., Baskerville, C.L., Bailey, S.R., de Laat, M.A., Anderson, S.T., Pollitt, C.C., Sillence, M.N.

“…Although it is understood that equine endocrinopathic laminitis can be triggered by high concentrations of insulin, it is unclear whether this represents a…”
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Diurnal rhythm and effects of feeding, exercise and recombinant equine growth hormone on serum insulin concentrations in the horse by Noble, G. K, Sillence, M. N

“…REASONS FOR PERFORMING THE STUDY: As growth hormone increases lean body mass, it could be a therapy for obese horses. However, growth hormone use induces…”
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Characterization of insulin and IGF-1 receptor binding in equine liver and lamellar tissue: implications for endocrinopathic laminitis by Nanayakkara, S.N., Rahnama, S., Harris, P.A., Anderson, S.T., de Laat, M.A., Bailey, S., Sillence, M.N.

“…Although it is well established that equine laminitis can be triggered by extreme hyperinsulinemia, the mechanism of insulin action is not known. High…”
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Identification of monoclonal antibodies suitable for blocking IGF-1 receptors in the horse by Rahnama, S., Vathsangam, N., Spence, R., Anderson, S.T., de Laat, M.A., Bailey, S., Sillence, M.N.

“…Prolonged hyperinsulinemia is thought to be the cause of equine endocrinopathic laminitis, a common and crippling disease of the foot, for which there are no…”
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‘Supersize me’: On equine obesity by Sillence, M.N.

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