Search Results - "Sillaber, I."

Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation by Webhofer, C, Gormanns, P, Tolstikov, V, Zieglgänsberger, W, Sillaber, I, Holsboer, F, Turck, C W

“…Currently used antidepressants elevate monoamine levels in the synaptic cleft. There is good reason to assume that this is not the only source for…”
Get full text

Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system by Keck, M.E, Welt, T, Müller, M.B, Erhardt, A, Ohl, F, Toschi, N, Holsboer, F, Sillaber, I

“…Repetitive transcranial magnetic stimulation (rTMS) is suggested to be a potentially useful treatment in major depression. In order to optimize rTMS for…”
Get full text

Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems by Park, D I, Dournes, C, Sillaber, I, Ising, M, Asara, J M, Webhofer, C, Filiou, M D, Müller, M B, Turck, C W

“…The aim of this study was to identify molecular pathways related to antidepressant response. We administered paroxetine to the DBA/2J mice for 28 days…”
Get full text

Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice by Thoeringer, CK, Erhardt, A., Sillaber, I., Mueller, MB, Ohl, F., Holsboer, F., Keck, ME

“…Gamma-aminobutyric acid (GABA) system plays a pivotal role in the pathophysiology of anxiety and mood disorders. This study was aimed to assess the anxiolytic…”
Get full text

Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response by Ganea, K, Menke, A, Schmidt, M V, Lucae, S, Rammes, G, Liebl, C, Harbich, D, Sterlemann, V, Storch, C, Uhr, M, Holsboer, F, Binder, E B, Sillaber, I, Müller, M B

“…Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful…”
Get full text

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence by ERHARDT, A, SILLABER, I, WELT, T, MÜLLER, M. B, SINGEWALD, N, KECK, M. E

“…Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic…”
Get full text

Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids by Müller, M B, Landgraf, R, Preil, J, Sillaber, I, Kresse, A E, Keck, M E, Zimmermann, S, Holsboer, F, Wurst, W

“…Deficiency of CRH receptor 1 (CRHR1) severely impairs the stress response of the hypothalamic-pituitary-adrenocortical (HPA) system and reduces anxiety-related…”
Get full text

Critical role of the embryonic mid–hindbrain organizer in the behavioral response to amphetamine and methylphenidate by Tilleman, H, Kofman, O, Nashelsky, L, Livneh, U, Roz, N, Sillaber, I, Biegon, A, Rehavi, M, Brodski, C

“…Abstract The embryonic mid–hindbrain organizer, which is composed of a transient cell population in the brainstem, controls the development of dopaminergic and…”
Get full text

Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area — Possible novel signalling pathways by Tsolakidou, A., Trümbach, D., Panhuysen, M., Pütz, B., Deussing, J., Wurst, W., Sillaber, I., Holsboer, F., Rein, T.

“…Stress exposure can lead to the precipitation of psychiatric disorders in susceptible individuals, but the molecular underpinnings are incompletely understood…”
Get full text

Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain by Izawa, R., Jaber, M., Deroche-Gamonet, V., Sillaber, I., Kellendonk, C., Le Moal, M., Tronche, F., Piazza, P.V.

“…Several findings suggest that glucocorticoid hormones influence the propensity of an individual to develop cocaine abuse. These hormones activate two related…”
Get full text

P.1.36 Identification and validation of new antidepressant-responsive gene candidates in mouse brain by Ganea, K, Sillaber, I, Henniger, M.S.H, Liebl, C, Panhuysen, M, Pütz, B, Schmidt, M.V, Sterlemann, V, Storch, C, Müller, M.B

Get full text

Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide by Sillaber, I, Montkowski, A, Landgraf, R, Barden, N, Holsboer, F, Spanagel, R

“…In vivo microdialysis experiments were conducted in transgenic mice with impaired glucocorticoid receptor function resulting from expression of antisense…”
Get full text

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress by Wurst, Wolfgang, Müller, Marianne B, Zimmermann, Stephan, Sillaber, Inge, Hagemeyer, Thomas P, Deussing, Jan M, Timpl, Peter, Kormann, Michael S D, Droste, Susanne K, Kühn, Ralf, Reul, Johannes M H M, Holsboer, Florian

“…Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate…”
Get full text

Enhanced and Delayed Stress-Induced Alcohol Drinking in Mice Lacking Functional CRH1 Receptors by Sillaber, Inge, Rammes, Gerhard, Zimmermann, Stephan, Mahal, Beatrice, Zieglgänsberger, Walter, Wurst, Wolfgang, Holsboer, Florian, Spanagel, Rainer

“…There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral…”
Get full text

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 by Wurst, Wolfgang, Timpl, Peter, Spanagel, Rainer, Sillaber, Inge, Kresse, Adelheid, Reul, Johannes M. H. M, Stalla, Günter K, Blanquet, Veronique, Steckler, Thomas, Holsboer, Florian

“…Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the…”
Get full text

The Glucocorticoid Receptor as a Potential Target to Reduce Cocaine Abuse by Deroche-Gamonet, Veronique, Sillaber, Inge, Aouizerate, Bruno, Izawa, Ryozuke, Jaber, Mohamed, Ghozland, Sandy, Kellendonk, Christoph, Le Moal, Michel, Spanagel, Rainer, Schutz, Gunther, Tronche, Francois, Piazza, Pier Vincenzo

“…Several findings suggest that glucocorticoid hormones are involved in determining the propensity of an individual to develop cocaine abuse. These hormones…”
Get full text

Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2 by Preil, J, Müller, M B, Gesing, A, Reul, J M, Sillaber, I, van Gaalen, M M, Landgrebe, J, Holsboer, F, Stenzel-Poore, M, Wurst, W

“…Recent investigations in mouse lines either deficient for the CRH receptor 1 (CRHR1) or 2 (CRHR2) suggest that the CRH neuronal system may comprise two…”
Get full text

Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain-Hindbrain Organizer by Brodski, Claude, Weisenhorn, Daniela M. Vogt, Signore, Massimo, Sillaber, Inge, Oesterheld, Matthias, Broccoli, Vania, Acampora, Dario, Simeone, Antonio, Wurst, Wolfgang

“…Midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric…”
Get full text

The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol by Spanagel, Rainer, Siegmund, Soren, Cowen, Michael, Schroff, Karl-Christian, Schumann, Gunter, Fiserova, Magdalena, Sillaber, Inge, Wellek, Stefan, Singer, Manfred, Putzke, Jorg

“…In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient…”
Get full text

Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain by Keck, Martin E., Sillaber, Inge, Ebner, Karl, Welt, Tobias, Toschi, Nicola, Kaehler, Stefan T., Singewald, Nicolas, Philippu, Athineos, Elbel, Gregor K., Wotjak, Carsten T., Holsboer, Florian, Landgraf, Rainer, Engelmann, Mario

“…Using intracerebral microdialysis in urethane‐anaesthetized adult male Wistar rats, we monitored the effects of acute repetitive transcranial magnetic…”
Get full text