Search Results - "Silkstone, Gary G. A."

Taming hemoglobin chemistry—a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation by Cooper, Chris E., Simons, Michelle, Dyson, Alex, Leiva Eriksson, Nélida, Silkstone, Gary G. A., Syrett, Natalie, Allen-Baume, Victoria, Bülow, Leif, Ronda, Luca, Mozzarelli, Andrea, Singer, Mervyn, Reeder, Brandon J.

“…The clinical utility of hemoglobin-based oxygen carriers (HBOC) is limited by adverse heme oxidative chemistry. A variety of tyrosine residues were inserted on…”
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Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality by Cooper, Chris E, Silkstone, Gary G A, Simons, Michelle, Gretton, Svetlana, Rajagopal, Badri S, Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Popa, Gina, Sheng, XiaoBo, Bird, Matthew, Choi, Ji-Won, Piano, Riccardo, Ronda, Luca, Bettati, Stefano, Paredi, Gianluca, Mozzarelli, Andrea, Reeder, Brandon J

“…In order to infuse hemoglobin into the vasculature as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the molecule to…”
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Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute by Cooper, Chris E., Silkstone, Gary G.A., Simons, Michelle, Rajagopal, Badri, Syrett, Natalie, Shaik, Thoufieq, Gretton, Svetlana, Welbourn, Elizabeth, Bülow, Leif, Eriksson, Nélida Leiva, Ronda, Luca, Mozzarelli, Andrea, Eke, Andras, Mathe, Domokos, Reeder, Brandon J.

“…Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes…”
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Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design by Silkstone, Gary G A, Silkstone, Rebecca S, Wilson, Michael T, Simons, Michelle, Bülow, Leif, Kallberg, Kristian, Ratanasopa, Khuanpiroon, Ronda, Luca, Mozzarelli, Andrea, Reeder, Brandon J, Cooper, Chris E

“…Hemoglobin (Hb)-based oxygen carriers (HBOC) have been engineered to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results…”
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Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers by Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G A, Rajagopal, Badri S, Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B, Alayash, Abdu I, Reeder, Brandon J, Cooper, Chris E

“…Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been engineered to replace or augment the oxygen carrying capacity of erythrocytes. However, clinical…”
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Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit by Cooper, Chris E, Bird, Matthew, Sheng, XiaoBo, Choi, Ji-Won, Silkstone, Gary G A, Simons, Michelle, Syrett, Natalie, Piano, Riccardo, Ronda, Luca, Bettati, Stefano, Paredi, Gianluca, Mozzarelli, Andrea, Reeder, Brandon J

“…In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule…”
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