Search Results - "Siliciano, R F"

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy by Dinoso, J.B, Kim, S.Y, Wiegand, A.M, Palmer, S.E, Gange, S.J, Cranmer, L, O'Shea, A, Callender, M, Spivak, A, Brennan, T, Kearney, M.F, Proschan, M.A, Mican, J.M, Rehm, C.A, Coffin, J.M, Mellors, J.W, Siliciano, R.F, Maldarelli, F

“…In HIV-1-infected individuals on currently recommended antiretroviral therapy (ART), viremia is reduced to <50 copies of HIV-1 RNA per milliliter, but…”
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Marked Intraindividual Variability in Antiretroviral Concentrations May Limit the Utility of Therapeutic Drug Monitoring by Nettles, Richard E., Kieffer, Tara L., Parsons, Teresa, Johnson, James, Cofrancesco, Joseph, Gallant, Joel E., Carson, Kathryn A., Siliciano, Robert F., Flexner, Charles

“…Background. Effective therapeutic drug monitoring for antiretrovirals requires a better understanding of intraindividual variability in pharmacokinetics…”
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Discovery of Entry Inhibitors for HIV-1 via a New De Novo Protein Design Framework by Bellows, M.L., Taylor, M.S., Cole, P.A., Shen, L., Siliciano, R.F., Fung, H.K., Floudas, C.A.

“…A new (to our knowledge) de novo design framework with a ranking metric based on approximate binding affinity calculations is introduced and applied to the…”
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Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy by Finzi, Diana, Hermankova, Monika, Pierson, Theodore, Carruth, Lucy M., Buck, Christopher, Chaisson, Richard E., Quinn, Thomas C., Chadwick, Karen, Margolick, Joseph, Brookmeyer, Ronald, Gallant, Joel, Markowitz, Martin, Ho, David D., Richman, Douglas D., Siliciano, Robert F.

“…The hypothesis that quiescent CD4$^+$ T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus-type 1 (HIV-1) in patients on…”
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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection by Chun, Tae-Wook, Carruth, Lucy, Finzi, Diana, Shen, Xuefei, DiGiuseppe, Joseph A, Taylor, Harry, Hermankova, Monika, Chadwick, Karen, Margolick, Joseph, Quinn, Thomas C, Kuo, Yen-Hong, Brookmeyer, Ronald, Zeiger, Martha A, Barditch-Crovo, Patricia, Siliciano, Robert F

“…The capacity of HIV-1 to establish latent infection of CD4+ T cells may allow viral persistence despite immune responses and antiretroviral therapy…”
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A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1–Infected Adults on Antiretroviral Therapy by Spivak, Adam M., Andrade, Adriana, Eisele, Evelyn, Hoh, Rebecca, Bacchetti, Peter, Bumpus, Namandjé N., Emad, Fatemeh, Buckheit, Robert, McCance-Katz, Elinore F., Lai, Jun, Kennedy, Margene, Chander, Geetanjali, Siliciano, Robert F., Siliciano, Janet D., Deeks, Steven G.

“…Background. Transcriptionally silent human immunodeficiency virus type 1 (HIV-1) DNA persists in resting memory CD4 + T cells despite antiretroviral therapy…”
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The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site by Buck, C B, Shen, X, Egan, M A, Pierson, T C, Walker, C M, Siliciano, R F

“…Several retroviruses have recently been shown to promote translation of their gag gene products by internal ribosome entry. In this report, we show that mRNAs…”
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Characterization of Chemokine Receptor Utilization of Viruses in the Latent Reservoir for Human Immunodeficiency Virus Type 1 by Pierson, T, Hoffman, T L, Blankson, J, Finzi, D, Chadwick, K, Margolick, J B, Buck, C, Siliciano, J D, Doms, R W, Siliciano, R F

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Latency and reservoirs for HIV-1 by Siliciano, R F

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Treatment of Human Immunodeficiency Virus Infection with Hydroxyurea, Didanosine, and a Protease Inhibitor before Seroconversion Is Associated with Normalized Immune Parameters and Limited Viral Reservoir by Lori, Franco, Jessen, Heiko, Lieberman, Judy, Finzi, Diana, Rosenberg, Eric, Tinelli, Carmine, Walker, Bruce, Siliciano, Robert F., Lisziewicz, Julianna

“…Current treatments for human immunodeficiency virus (HIV) require uninterrupted drug administration because they are unable to reconstitute the immune response…”
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A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions by Gupta, K, Ott, D, Hope, T J, Siliciano, R F, Boeke, J D

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Proliferative Responses to Human Immunodeficiency Virus Type 1 (HIV-1) Antigens in HIV-1—Infected Patients with Immune Reconstitution by Blankson, Joel N., Gallant, Joel E., Siliciano, Robert F.

“…Cell-mediated immunity is affected early in human immunodeficiency virus type 1 (HIV-1) infection. HIV-1—specific CD4+ T cell proliferative responses are not…”
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Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Cytolytic T Lymphocyte Responses in Seronegative Adults by a Nonreplicating, Host-Range-Restricted Canarypox Vector (ALVAC) Carrying the HIV-1MN env Gene by Egan, Michael A., Pavlat, Wendy A., Tartaglia, James, Paoletti, Enzo, Weinhold, K. J., Clements, Mary Lou, Siliciano, Robert F.

“…CD8+ cytolytic T lymphocytes (CTL) are likely to be an important component of effective vaccines against human immunodeficiency virus type 1 (HIV-1). CTL can…”
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THE CHALLENGE OF VIRAL RESERVOIRS IN HIV-1 INFECTION by Blankson, Joel N, Persaud, Deborah, Siliciano, Robert F

“…A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more…”
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Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI by Chun, T W, Chadwick, K, Margolick, J, Siliciano, R F

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HIV-1 suppression by early treatment with hydroxyurea, didanosine, and a protease inhibitor by Lisziewicz, Julianna, Jessen, Heiko, Finzi, Diana, Siliciano, Robert F, Lori, Franco

“…A study investigated the antiviral efficacy of combination therapies for HIV-1 suppression by targeting simultaneously reservoir cells and the virus. The…”
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Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion by Siliciano, R F, Lawton, T, Knall, C, Karr, R W, Berman, P, Gregory, T, Reinherz, E L

“…The primary human T cell response to HIV was analyzed by isolating from seronegative donors T cell clones specific for HIV gp120. T cell epitopes restricted by…”
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Reservoirs for HIV-1: Mechanisms for Viral Persistence in the Presence of Antiviral Immune Responses and Antiretroviral Therapy by Pierson, Theodore, McArthur, Justin, Siliciano, Robert F

“…The success of combination antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite…”
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The human NTT gene : Identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4+ T cells by LIU, A. Y, TORCHIA, B. S, MIGEON, B. R, SILICIANO, R. F

“…We describe the cloning and characterization of the NTT gene (noncoding transcript in T cells), identified by differential display RT-PCR based on the…”
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Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy by Siliciano, Robert F, Finzi, Diana, Blankson, Joel, Siliciano, Janet D, Margolick, Joseph B, Chadwick, Karen, Pierson, Theodore, Smith, Kendall, Lisziewicz, Julianna, Lori, Franco, Flexner, Charles, Quinn, Thomas C, Chaisson, Richard E, Rosenberg, Eric, Walker, Bruce, Gange, Stephen, Gallant, Joel

“…Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection…”
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