Search Results - "Siliciano, Janet D."

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure by Ho, Ya-Chi, Shan, Liang, Hosmane, Nina N., Wang, Jeffrey, Laskey, Sarah B., Rosenbloom, Daniel I.S., Lai, Jun, Blankson, Joel N., Siliciano, Janet D., Siliciano, Robert F.

“…Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting CD4+ T cells. T cell activation reverses latency, but <1% of…”
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In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure by Siliciano, Janet D, Siliciano, Robert F

“…Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and allow persons living with HIV-1 (PLWH) to lead relatively normal…”
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HIV-1 Integration Landscape during Latent and Active Infection by Cohn, Lillian B., Silva, Israel T., Oliveira, Thiago Y., Rosales, Rafael A., Parrish, Erica H., Learn, Gerald H., Hahn, Beatrice H., Czartoski, Julie L., McElrath, M. Juliana, Lehmann, Clara, Klein, Florian, Caskey, Marina, Walker, Bruce D., Siliciano, Janet D., Siliciano, Robert F., Jankovic, Mila, Nussenzweig, Michel C.

“…The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent proviruses. To characterize these latently infected cells, we…”
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New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo by Bullen, C Korin, Laird, Gregory M, Durand, Christine M, Siliciano, Janet D, Siliciano, Robert F

“…Latency-reversing agents (LRAs) have been tested in HIV-1–infected individuals in the hopes of activating the latent viral reservoir and contributing to…”
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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations by Deng, Kai, Pertea, Mihaela, Rongvaux, Anthony, Wang, Leyao, Durand, Christine M., Ghiaur, Gabriel, Lai, Jun, McHugh, Holly L., Hao, Haiping, Zhang, Hao, Margolick, Joseph B., Gurer, Cagan, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Deeks, Steven G., Strowig, Till, Kumar, Priti, Siliciano, Janet D., Salzberg, Steven L., Flavell, Richard A., Shan, Liang, Siliciano, Robert F.

“…Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by…”
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Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1 by Siliciano, Janet D., PhD, Siliciano, Robert F., MD, PhD

“…HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in…”
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Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay by Laird, Gregory M, Eisele, Evelyn E, Rabi, S Alireza, Lai, Jun, Chioma, Stanley, Blankson, Joel N, Siliciano, Janet D, Siliciano, Robert F

“…HIV-1 persists in infected individuals in a stable pool of resting CD4(+) T cells as a latent but replication-competent provirus. This latent reservoir is the…”
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Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane by Wang, Zheng, Gurule, Evelyn E., Brennan, Timothy P., Gerold, Jeffrey M., Kwon, Kyungyoon J., Hosmane, Nina N., Kumar, Mithra R., Beg, Subul A., Capoferri, Adam A., Ray, Stuart C., Ho, Ya-Chi, Hill, Alison L., Siliciano, Janet D., Siliciano, Robert F.

“…The latent reservoir for HIV-1 in resting CD4⁺ T cells is a major barrier to cure. Several lines of evidence suggest that the latent reservoir is maintained…”
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HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study by Henrich, Timothy J, Hatano, Hiroyu, Bacon, Oliver, Hogan, Louise E, Rutishauser, Rachel, Hill, Alison, Kearney, Mary F, Anderson, Elizabeth M, Buchbinder, Susan P, Cohen, Stephanie E, Abdel-Mohsen, Mohamed, Pohlmeyer, Christopher W, Fromentin, Remi, Hoh, Rebecca, Liu, Albert Y, McCune, Joseph M, Spindler, Jonathan, Metcalf-Pate, Kelly, Hobbs, Kristen S, Thanh, Cassandra, Gibson, Erica A, Kuritzkes, Daniel R, Siliciano, Robert F, Price, Richard W, Richman, Douglas D, Chomont, Nicolas, Siliciano, Janet D, Mellors, John W, Yukl, Steven A, Blankson, Joel N, Liegler, Teri, Deeks, Steven G

“…It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2…”
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Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods by White, Jennifer A, Kufera, Joshua T, Bachmann, Niklas, Dai, Weiwei, Simonetti, Francesco R, Armstrong, Ciara, Lai, Jun, Beg, Subul, Siliciano, Janet D, Siliciano, Robert F

“…Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4 + T…”
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Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies by Eriksson, Susanne, Graf, Erin H, Dahl, Viktor, Strain, Matthew C, Yukl, Steven A, Lysenko, Elena S, Bosch, Ronald J, Lai, Jun, Chioma, Stanley, Emad, Fatemeh, Abdel-Mohsen, Mohamed, Hoh, Rebecca, Hecht, Frederick, Hunt, Peter, Somsouk, Ma, Wong, Joseph, Johnston, Rowena, Siliciano, Robert F, Richman, Douglas D, O'Doherty, Una, Palmer, Sarah, Deeks, Steven G, Siliciano, Janet D

“…HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small,…”
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Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation by SIFEI XING, BULLEN, Cynthia K, MARGOLIS, David M, SILICIANO, Janet D, SILICIANO, Robert F, SHROFF, Neeta S, LIANG SHAN, YANG, Hung-Chih, MANUCCI, Jordyn L, BHAT, Shridhar, HAO ZHANG, MARGOLICK, Joseph B, QUINN, Thomas C

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CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells by Cockerham, Leslie R, Siliciano, Janet D, Sinclair, Elizabeth, O'Doherty, Una, Palmer, Sarah, Yukl, Steven A, Strain, Matt C, Chomont, Nicolas, Hecht, Frederick M, Siliciano, Robert F, Richman, Douglas D, Deeks, Steven G

“…The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also…”
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Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques by Walker-Sperling, Victoria E. K., Mercado, Noe B., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Lewis, Mark, Murry, Jeffrey P., Yang, Yunling, Geleziunas, Romas, Robb, Merlin L., Michael, Nelson L., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Barouch, Dan H.

“…The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies have shown that therapeutic vaccination or broadly…”
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Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough by Han, Yefei, Lin, Yijie B, An, Wenfeng, Xu, Jie, Yang, Hung-Chih, O'Connell, Karen, Dordai, Dominic, Boeke, Jef D, Siliciano, Janet D, Siliciano, Robert F

“…Integrated HIV-1 genomes are found within actively transcribed host genes in latently infected CD4(+) T cells. Readthrough transcription of the host gene might…”
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Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors by BLANKSON, Joel N, BAILEY, Justin R, THAYIL, Seema, YANG, Hung-Chih, LASSEN, Kara, JUN LAI, GANDHI, Shiv K, SILICIANO, Janet D, WILLIAMS, Thomas M, SILICIANO, Robert F

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Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy by BRENNAN, Timothy P, WOODS, John O, SEDAGHAT, Ahmad R, SILICIANO, Janet D, SILICIANO, Robert F, WILKE, Claus O

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Influence of Host Gene Transcription Level and Orientation on HIV-1 Latency in a Primary-Cell Model by Shan, Liang, Yang, Hung-Chih, Rabi, S Alireza, Bravo, Hector C, Shroff, Neeta S, Irizarry, Rafael A, Zhang, Hao, Margolick, Joseph B, Siliciano, Janet D, Siliciano, Robert F

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Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions by Hill, Alison L, Rosenbloom, Daniel I S, Siliciano, Janet D, Siliciano, Robert F

“…Funding: This work was supported by National Institutes of Health DP5OD019851, T15LM007079, R01GM117591, R01AI043222; Martin Delaney CARE and DARE…”
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Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size by Rosenbloom, Daniel I S, Bacchetti, Peter, Stone, Mars, Deng, Xutao, Bosch, Ronald J, Richman, Douglas D, Siliciano, Janet D, Mellors, John W, Deeks, Steven G, Ptak, Roger G, Hoh, Rebecca, Keating, Sheila M, Dimapasoc, Melanie, Massanella, Marta, Lai, Jun, Sobolewski, Michele D, Kulpa, Deanna A, Busch, Michael P

“…Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing…”
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