Search Results - "Siletsky, Sergey"

Proton Pumps: Molecular Mechanisms, Inhibitors and Activators of Proton Pumping by Siletsky, Sergey A

“…Protein molecular machines, also known as proton pumps, are the most important element of biological membranes [...]…”
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Proton Pumping and Non-Pumping Terminal Respiratory Oxidases: Active Sites Intermediates of These Molecular Machines and Their Derivatives by Siletsky, Sergey A, Borisov, Vitaliy B

“…Terminal respiratory oxidases are highly efficient molecular machines. These most important bioenergetic membrane enzymes transform the energy of chemical…”
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Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets by Borisov, Vitaliy B, Siletsky, Sergey A, Paiardini, Alessandro, Hoogewijs, David, Forte, Elena, Giuffrè, Alessandro, Poole, Robert K

“…Cytochrome is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role…”
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ROS Defense Systems and Terminal Oxidases in Bacteria by Borisov, Vitaliy B., Siletsky, Sergey A., Nastasi, Martina R., Forte, Elena

“…Reactive oxygen species (ROS) comprise the superoxide anion (O2•−), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and singlet oxygen (1O2). ROS can damage…”
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Steps of the coupled charge translocation in the catalytic cycle of cytochrome c oxidase by Siletsky, Sergey A

“…Cytochrome c oxidase (COX) terminates the respiratory chain in mitochondria and in plasmatic membrane of many aerobic bacteria. The enzyme reduces dioxygen…”
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In the respiratory chain of Escherichia coli cytochromes bd-I and bd-II are more sensitive to carbon monoxide inhibition than cytochrome bo3 by Forte, Elena, Borisov, Vitaliy B., Siletsky, Sergey A., Petrosino, Maria, Giuffrè, Alessandro

“…Bacteria can not only encounter carbon monoxide (CO) in their habitats but also produce the gas endogenously. Bacterial respiratory oxidases, thus, represent…”
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Time-Resolved Electrometric Study of the F→O Transition in Cytochrome c Oxidase. The Effect of Zn2+ Ions on the Positive Side of the Membrane by Siletsky, Sergey A., Gennis, Robert B.

“…The effect of Zn 2+ on the P-side of proteoliposomes containing membrane-incorporated Rhodobacter sphaeroides cytochrome c oxidase was investigated by the…”
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Evidence for Fast Electron Transfer between the High-Spin Haems in Cytochrome bd-I from Escherichia coli by Siletsky, Sergey A, Rappaport, Fabrice, Poole, Robert K, Borisov, Vitaliy B

“…Cytochrome bd-I is one of the three proton motive force-generating quinol oxidases in the O2-dependent respiratory chain of Escherichia coli. It contains one…”
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Cytochrome c oxidase: Charge translocation coupled to single-electron partial steps of the catalytic cycle by Siletsky, Sergey A., Konstantinov, Alexander A.

“…The paper presents a survey of time-resolved studies of charge translocation by cytochrome c oxidase coupled to transfer of the 1st, 2nd 3rd and 4th electrons…”
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Photosystem II and terminal respiratory oxidases: molecular machines operating in opposite directions by Siletsky, Sergey A, Borisov, Vitaliy B, Mamedov, Mahir D

“…In the thylakoid membrane of green plants, cyanobacteria and algae, photosystem II (PSII) uses light energy to split water and generate molecular oxygen. In…”
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Time-resolved generation of membrane potential by ba3 cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and OH states by Siletsky, Sergey A., Belevich, Ilya, Belevich, Nikolai P., Soulimane, Tewfik, Wikström, Mårten

“…Two electrogenic phases with characteristic times of ~14μs and ~290μs are resolved in the kinetics of membrane potential generation coupled to single-electron…”
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Oriented Insertion of ESR-Containing Hybrid Proteins in Proteoliposomes by Petrovskaya, Lada E, Lukashev, Evgeniy P, Mamedov, Mahir D, Kryukova, Elena A, Balashov, Sergei P, Dolgikh, Dmitry A, Rubin, Andrei B, Kirpichnikov, Mikhail P, Siletsky, Sergey A

“…Microbial rhodopsins comprise a diverse family of retinal-containing membrane proteins that convert absorbed light energy to transmembrane ion transport or…”
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His57 controls the efficiency of ESR, a light-driven proton pump from Exiguobacterium sibiricum at low and high pH by Siletsky, Sergey A., Lukashev, Evgeniy P., Mamedov, Mahir D., Borisov, Vitaliy B., Balashov, Sergei P., Dolgikh, Dmitriy A., Rubin, Andrei B., Kirpichnikov, Mikhail P., Petrovskaya, Lada E.

“…ESR, a light-driven proton pump from Exiguobacterium sibiricum, contains a lysine residue (Lys96) in the proton donor site. Substitution of Lys96 with a…”
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Cytochrome bd from Escherichia coli catalyzes peroxynitrite decomposition by Borisov, Vitaliy B, Forte, Elena, Siletsky, Sergey A, Sarti, Paolo, Giuffrè, Alessandro

“…Cytochrome bd is a prokaryotic respiratory quinol oxidase phylogenetically unrelated to heme-copper oxidases, that was found to promote virulence in some…”
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In Escherichia coli Ammonia Inhibits Cytochrome bo3 But Activates Cytochrome bd-I by Forte, Elena, Siletsky, Sergey A., Borisov, Vitaliy B.

“…Interaction of two redox enzymes of Escherichia coli, cytochrome bo3 and cytochrome bd-I, with ammonium sulfate/ammonia at pH 7.0 and 8.3 was studied using…”
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Microsecond time-resolved absorption spectroscopy used to study CO compounds of cytochrome bd from Escherichia coli by Siletsky, Sergey A, Zaspa, Andrey A, Poole, Robert K, Borisov, Vitaliy B

“…Cytochrome bd is a tri-heme (b558, b595, d) respiratory oxygen reductase that is found in many bacteria including pathogenic species. It couples the electron…”
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Proton transfer reactions in donor site mutants of ESR, a retinal protein from Exiguobacterium sibiricum by Petrovskaya, Lada E., Lukashev, Evgeniy P., Siletsky, Sergey A., Imasheva, Eleonora S., Wang, Jennifer M., Mamedov, Mahir D., Kryukova, Elena A., Dolgikh, Dmitriy A., Rubin, Andrei B., Kirpichnikov, Mikhail P., Balashov, Sergei P., Lanyi, Janos K.

“…Light-driven proton transport by microbial retinal proteins such as archaeal bacteriorhodopsin involves carboxylic residues as internal proton donors to the…”
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Elimination of proton donor strongly affects directionality and efficiency of proton transport in ESR, a light-driven proton pump from Exiguobacterium sibiricum by Siletsky, Sergey A., Mamedov, Mahir D., Lukashev, Evgeniy P., Balashov, Sergei P., Dolgikh, Dmitriy A., Rubin, Andrei B., Kirpichnikov, Mikhail P., Petrovskaya, Lada E.

“…ESR from Exiguobacterium sibiricum is a retinal protein which functions as a proton pump. Unusual feature of ESR is that a lysine residue is present at a site…”
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Application of direct electrometry in studies of microbial rhodopsins reconstituted in proteoliposomes by Siletsky, Sergey A., Mamedov, Mahir D., Lukashev, Evgeniy P., Balashov, Sergei P., Petrovskaya, Lada E.

“…  Microbial rhodopsins are the family of retinal-containing proteins that perform primarily the light-driven transmembrane ion transport and sensory functions…”
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Electrogenic steps of light-driven proton transport in ESR, a retinal protein from Exiguobacterium sibiricum by Siletsky, Sergey A., Mamedov, Mahir D., Lukashev, Evgeniy P., Balashov, Sergei P., Dolgikh, Dmitriy A., Rubin, Andrei B., Kirpichnikov, Mikhail P., Petrovskaya, Lada E.

“…A retinal protein from Exiguobacterium sibiricum (ESR) functions as a light-driven proton pump. Unlike other proton pumps, it contains Lys96 instead of a usual…”
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