Protective effects of a soy diet in preventing obesity-linked renal disease

Protective effects of a soy diet in preventing obesity-linked renal disease. Hypertension, hyperlipidemia, hyperfiltration, hyperinsulinemia, glomerular hypertrophy, and ultimately glomerular injury and renal failure are associated with obesity in the Zucker rat. Evidence from other laboratories sug...

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Bibliographic Details
Published in:	Kidney international Vol. 61; no. 1; pp. 96 - 104
Main Authors:	Maddox, David A., Alavi, Fred K., Silbernick, Elizabeth M., Zawada, Edward T.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-01-2002 Nature Publishing Elsevier Limited
Subjects:	Animals Biological and medical sciences Blood Pressure Caseins - pharmacology Diet dietary soy protein Diseases of the urinary system Eating Female glomerular disease Glomerular Filtration Rate hypercholesterolemia Hypercholesterolemia - diet therapy Hypercholesterolemia - etiology Hypercholesterolemia - prevention & control hyperlipidemia hypertension Hypertension, Renal - diet therapy Hypertension, Renal - etiology Hypertension, Renal - prevention & control Kidney - pathology Medical sciences Obesity - complications Organ Size overweight Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Zucker renal failure Renal Insufficiency - diet therapy Renal Insufficiency - etiology Renal Insufficiency - prevention & control Sodium - urine Soybean Proteins - pharmacology blood pressure hyperlipidemia dietary soy protein renal failure glomerular disease hypertension overweight hypercholesterolemia Human Kidney disease Obesity Urinary system disease Nutrition disorder Metabolic diseases Lipids Soybean Prevention Concomitant disease Treatment Diet Hyperlipemia Dyslipemia Nutritional status
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Summary:	Protective effects of a soy diet in preventing obesity-linked renal disease. Hypertension, hyperlipidemia, hyperfiltration, hyperinsulinemia, glomerular hypertrophy, and ultimately glomerular injury and renal failure are associated with obesity in the Zucker rat. Evidence from other laboratories suggests that soy protein might offer renal protection. At five weeks of age obese rats were placed on diets containing either soy or casein as a protein source and studied until 24 weeks of age. At six weeks of age and every four weeks thereafter, 24-hour urine collections were obtained along with measurements of systolic blood pressure (tail cuff) and blood from the tail vein. At the end of the study the kidneys were fixed and sectioned for histology. Both groups gained weight and developed systemic hypertension and hyperinsulinemia at the same rate. Glomerular filtration rate (creatinine clearance) also was similar between groups throughout the study and both groups developed glomerular hypertrophy to the same extent. The development of hypertriglyceridemia was actually accelerated in the soy-fed rats compared to the casein-fed animals. The soy diet, however, virtually completely prevented the development of hypercholesterolemia, primarily low-density lipoprotein (LDL) and/or very low-density lipoprotein (VLDL) cholesterol, and slowed the development of proteinuria and glomerular injury. The data suggest that an important determinant of the protective effects of soy was related to the prevention of hypercholesterolemia in this model. Other unmeasured differences between groups, such as differences in glomerular capillary blood pressure or the effects of the antioxidant properties of soy components also may have contributed to the protective effects of soy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0085-2538 1523-1755
DOI:	10.1046/j.1523-1755.2002.00091.x