Search Results - "Silberman, Rebecca E."

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo by Pfau, Sarah J, Silberman, Rebecca E, Knouse, Kristin A, Amon, Angelika

“…Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate…”
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Mechanisms for Curing Yeast Prions by Greene, Lois E, Saba, Farrin, Silberman, Rebecca E, Zhao, Xiaohong

“…Prions are infectious proteins that self-propagate by changing from their normal folded conformation to a misfolded conformation. The misfolded conformation,…”
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Aneuploidy Causes Non-genetic Individuality by Beach, Rebecca R., Ricci-Tam, Chiara, Brennan, Christopher M., Moomau, Christine A., Hsu, Pei-hsin, Hua, Bo, Silberman, Rebecca E., Springer, Michael, Amon, Angelika

“…Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought…”
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Inherent genome instability underlies trisomy 21-associated myeloid malignancies by Chen, Chun-Chin, Silberman, Rebecca E., Ma, Duanduan, Perry, Jennifer A., Khalid, Delan, Pikman, Yana, Amon, Angelika, Hemann, Michael T., Rowe, R. Grant

“…Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high incidence of childhood acute myeloid leukemia (AML). T21-associated AML is…”
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Heat shock protein 104 (Hsp104)-mediated curing of [PSI+] yeast prions depends on both [PSI+] conformation and the properties of the Hsp104 homologs by Zhao, Xiaohong, Rodriguez, Ramon, Silberman, Rebecca E., Ahearn, Joseph M., Saidha, Sheela, Cummins, Kaelyn C., Eisenberg, Evan, Greene, Lois E.

“…Prions arise from proteins that have two possible conformations: properly folded and non-infectious or misfolded and infectious. The [PSI+] yeast prion, which…”
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A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution by Rozhok, Andrii I., Silberman, Rebecca E., Higa, Kelly C., Liggett, L. Alex, Amon, Angelika, DeGregori, James

“…Aneuploidy is a feature of many cancers. Recent studies demonstrate that in the hematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells have…”
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Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers by Karaayvaz-Yildirim, Mihriban, Silberman, Rebecca E, Langenbucher, Adam, Saladi, Srinivas Vinod, Ross, Kenneth N, Zarcaro, Elena, Desmond, Andrea, Yildirim, Murat, Vivekanandan, Varunika, Ravichandran, Hiranmayi, Mylavagnanam, Ravindra, Specht, Michelle C, Ramaswamy, Sridhar, Lawrence, Michael, Amon, Angelika, Ellisen, Leif W

“…Women harboring heterozygous germline mutations of have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly…”
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