Search Results - "Silber, Ariel M."

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector by Mantilla, Brian S, Marchese, Letícia, Casas-Sánchez, Aitor, Dyer, Naomi A, Ejeh, Nicholas, Biran, Marc, Bringaud, Frédéric, Lehane, Michael J, Acosta-Serrano, Alvaro, Silber, Ariel M

“…Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector,…”
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Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features by Michels, Paul A.M., Villafraz, Oriana, Pineda, Erika, Alencar, Mayke B., Cáceres, Ana J., Silber, Ariel M., Bringaud, Frédéric

“…The human pathogenic trypanosomatid species collectively called the “TriTryp parasites” – Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. – have…”
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Natural products as a source for treating neglected parasitic diseases by Ndjonka, Dieudonné, Rapado, Ludmila Nakamura, Silber, Ariel M, Liebau, Eva, Wrenger, Carsten

“…Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are…”
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Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline by Villafraz, Oriana, Biran, Marc, Pineda, Erika, Plazolles, Nicolas, Cahoreau, Edern, Ornitz Oliveira Souza, Rodolpho, Thonnus, Magali, Allmann, Stefan, Tetaud, Emmanuel, Rivière, Loïc, Silber, Ariel M, Barrett, Michael P, Zíková, Alena, Boshart, Michael, Portais, Jean-Charles, Bringaud, Frédéric

“…Trypanosoma brucei, a protist responsible for human African trypanosomiasis (sleeping sickness), is transmitted by the tsetse fly where the procyclic forms of…”
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Responsible Science Assessment: downplaying indexes, boosting quality by Kowaltowski, Alicia J, Silber, Ariel M, Oliveira, Marcus F

“…Scientists are facing enormous pressures posed by growing scientific communities and stagnant/reduced funding. In this scenario, mechanisms of knowledge…”
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The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues by Aldfer, Mustafa M, Alfayez, Ibrahim A, Elati, Hamza A A, Gayen, Nilanjana, Elmahallawy, Ehab Kotb, Milena Murillo, Ana, Marsiccobetre, Sabrina, Van Calenbergh, Serge, Silber, Ariel M, de Koning, Harry P

“…Among the scarce validated drug targets against Chagas disease (CD), caused by , the parasite's nucleoside salvage system has recently attracted considerable…”
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How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell by Nascimento, Janaina F, Souza, Rodolpho O O, Alencar, Mayke B, Marsiccobetre, Sabrina, Murillo, Ana M, Damasceno, Flávia S, Girard, Richard B M M, Marchese, Letícia, Luévano-Martinez, Luis A, Achjian, Renan W, Haanstra, Jurgen R, Michels, Paul A M, Silber, Ariel M

“…ATP hydrolysis is required for the synthesis, transport and polymerization of monomers for macromolecules as well as for the assembly of the latter into…”
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Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms by Lima, Alex R J, de Araujo, Christiane B, Bispo, Saloe, Patané, José, Silber, Ariel M, Elias, M Carolina, da Cunha, Julia P C

“…Trypanosoma cruzi alternates between replicative and nonreplicative life forms, accompanied by a shift in global transcription levels and by changes in the…”
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Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi by Shiratsubaki, Isabel S, Fang, Xin, Souza, Rodolpho O O, Palsson, Bernhard O, Silber, Ariel M, Siqueira-Neto, Jair L

“…Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This…”
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Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis by Dos Santos, Denis Amilton, Souza, Higo Fernando Santos, Silber, Ariel M, de Souza, Tatiana de Arruda Campos Brasil, Ávila, Andréa Rodrigues

“…The apicomplexan parasite is the causative agent of toxoplasmosis, a global disease that significantly impacts human health. The clinical manifestations are…”
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Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi by Magdaleno, Anahí, Ahn, Il-Young, Paes, Lisvane Silva, Silber, Ariel M

“…It is well established that L-proline has several roles in the biology of trypanosomatids. In Trypanosoma cruzi, the etiological agent of Chagas' disease, this…”
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Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci by Lima, Alex Ranieri Jerônimo, Silva, Herbert Guimarães de Sousa, Poubel, Saloe, Rosón, Juliana Nunes, de Lima, Loyze Paola Oliveira, Costa-Silva, Héllida Marina, Gonçalves, Camila Silva, Galante, Pedro A F, Holetz, Fabiola, Motta, Maria Cristina Machado, Silber, Ariel M, Elias, M Carolina, da Cunha, Julia Pinheiro Chagas

“…Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters…”
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Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci by Lima, Alex Ranieri Jerônimo, de Sousa Silva, Herbert Guimarães, Poubel, Saloe Bispo, Rosón, Juliana Nunes, de Lima, Loyze Paola Oliveira, Costa-Silva, Héllida Marina, Gonçalves, Camila Silva, Galante, Pedro A. F, Holetz, Fabiola, Motta, Maria Cristina Machado, Silber, Ariel M, Elias, M. Carolina, da Cunha, Julia Pinheiro Chagas

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CD4⁺ CD25⁺ Foxp3⁺ Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host Responses? by Gonçalves, Raquel M, Salmazi, Karina C, Santos, Bianca A.N, Bastos, Melissa S, Rocha, Sandra C, Boscardin, Sílvia B, Silber, Ariel M, Kallás, Esper G, Ferreira, Marcelo U, Scopel, Kézia K.G

“…Clearing blood-stage malaria parasites without inducing major host pathology requires a finely tuned balance between pro- and anti-inflammatory responses. The…”
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The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake by Merli, Marcelo L, Pagura, Lucas, Hernández, Josefina, Barisón, María Julia, Pral, Elizabeth M F, Silber, Ariel M, Cricco, Julia A

“…Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis…”
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Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania by Trinconi, Cristiana T., Miguel, Danilo C., Silber, Ariel M., Brown, Christopher, Mina, John G.M., Denny, Paul W., Heise, Norton, Uliana, Silvia R.B.

“…Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in…”
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Targeting L-Proline Uptake as New Strategy for Anti-chagas Drug Development by Fargnoli, Lucía, Panozzo-Zénere, Esteban A, Pagura, Lucas, Barisón, María Julia, Cricco, Julia A, Silber, Ariel M, Labadie, Guillermo R

“…L-Proline is an important amino acid for the pathogenic protists belonging to and genera. In , the etiological agent of Chagas disease, this amino acid is…”
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Aspartate aminotransferase: bridging carbohydrate and energy metabolism in Plasmodium falciparum by Wrenger, Carsten, Muller, Ingrid B, Silber, Ariel M, Jordanova, Rositsa, Lamzin, Victor S, Groves, Matthew R

“…In this mini-review we briefly examine and summarize evidence on the role of the plasmodial aspartate aminotransferase (AspAT) of the malarial parasite. Recent…”
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Trypanosome Prereplication Machinery Contains a Single Functional Orc1/Cdc6 Protein, Which Is Typical of Archaea by Godoy, Patrícia Diogo de Melo, Nogueira-Junior, Luis Antonio, Paes, Lisvane S, Cornejo, Alberto, Martins, Rafael Miyazawa, Silber, Ariel M, Schenkman, Sergio, Elias, M Carolina

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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l‐Proline is essential for the intracellular differentiation of Trypanosoma cruzi by Tonelli, Renata R., Silber, Ariel M., Almeida‐de‐Faria, Marinez, Hirata, Izaura Y., Colli, Walter, Alves, Maria Júlia M.

“…Summary Using as the host cell, a proline‐requiring mutant of Chinese hamster ovary cell (CHO‐K1), it was possible to arrest the differentiation of amastigote…”
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