Search Results - "Silani, Vincenzo"

Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia by Verde, Federico, Otto, Markus, Silani, Vincenzo

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related currently incurable neurodegenerative diseases. ALS is characterized by…”
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Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved? by Mitsumoto, Hiroshi, Dr, Brooks, Benjamin R, MD, Silani, Vincenzo, MD

“…Summary Amyotrophic lateral sclerosis (ALS) is one of the most rapidly progressive neurodegenerative diseases of unknown cause. Riluzole is the only drug that…”
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Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria by Strong, Michael J., Abrahams, Sharon, Goldstein, Laura H., Woolley, Susan, Mclaughlin, Paula, Snowden, Julie, Mioshi, Eneida, Roberts-South, Angie, Benatar, Michael, HortobáGyi, Tibor, Rosenfeld, Jeffrey, Silani, Vincenzo, Ince, Paul G, Turner, Martin R.

“…This article presents the revised consensus criteria for the diagnosis of frontotemporal dysfunction in amyotrophic lateral sclerosis (ALS) based on an…”
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Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis by Verde, Federico, Steinacker, Petra, Weishaupt, Jochen H, Kassubek, Jan, Oeckl, Patrick, Halbgebauer, Steffen, Tumani, Hayrettin, von Arnim, Christine A F, Dorst, Johannes, Feneberg, Emily, Mayer, Benjamin, Müller, Hans-Peter, Gorges, Martin, Rosenbohm, Angela, Volk, Alexander E, Silani, Vincenzo, Ludolph, Albert C, Otto, Markus

“…ObjectiveTo determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS).MethodsThis…”
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Primary lateral sclerosis: consensus diagnostic criteria by Turner, Martin R, Barohn, Richard J, Corcia, Philippe, Fink, John K, Harms, Matthew B, Kiernan, Matthew C, Ravits, John, Silani, Vincenzo, Simmons, Zachary, Statland, Jeffrey, van den Berg, Leonard H, Mitsumoto, Hiroshi

“…Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system. Characterised by a slowly progressive upper motor neuron syndrome,…”
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SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution by Maraschi, AnnaMaria, Gumina, Valentina, Dragotto, Jessica, Colombrita, Claudia, Mompeán, Miguel, Buratti, Emanuele, Silani, Vincenzo, Feligioni, Marco, Ratti, Antonia

“…The nuclear RNA-binding protein TDP-43 forms abnormal cytoplasmic aggregates in the brains of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia…”
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TDP-43 is recruited to stress granules in conditions of oxidative insult by Colombrita, Claudia, Zennaro, Eleonora, Fallini, Claudia, Weber, Markus, Sommacal, Andreas, Buratti, Emanuele, Silani, Vincenzo, Ratti, Antonia

“…Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic…”
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An Italian multicenter retrospective-prospective observational study on neurological manifestations of COVID-19 (NEUROCOVID) by Ferrarese, Carlo, Silani, Vincenzo, Priori, Alberto, Galimberti, Stefania, Agostoni, Elio, Monaco, Salvatore, Padovani, Alessandro, Tedeschi, Gioacchino

“…Neurological manifestations of COVID-19 have been described in both single case reports and retrospective scanty case series. They may be linked to the…”
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Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons by Ratti, Antonia, Gumina, Valentina, Lenzi, Paola, Bossolasco, Patrizia, Fulceri, Federica, Volpe, Clara, Bardelli, Donatella, Pregnolato, Francesca, Maraschi, AnnaMaria, Fornai, Francesco, Silani, Vincenzo, Colombrita, Claudia

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases characterized by the presence of neuropathological…”
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Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis by Feneberg, Emily, Oeckl, Patrick, Steinacker, Petra, Verde, Federico, Barro, Christian, Van Damme, Philip, Gray, Elizabeth, Grosskreutz, Julian, Jardel, Claude, Kuhle, Jens, Koerner, Sonja, Lamari, Foudil, Amador, Maria del Mar, Mayer, Benjamin, Morelli, Claudia, Muckova, Petra, Petri, Susanne, Poesen, Koen, Raaphorst, Joost, Salachas, François, Silani, Vincenzo, Stubendorff, Beatrice, Turner, Martin R, Verbeek, Marcel M, Weishaupt, Jochen H, Weydt, Patrick, Ludolph, Albert C, Otto, Markus

“…OBJECTIVETo examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis…”
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EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force by Andersen, Peter M., Abrahams, Sharon, Borasio, Gian D., de Carvalho, Mamede, Chio, Adriano, Van Damme, Philip, Hardiman, Orla, Kollewe, Katja, Morrison, Karen E., Petri, Susanne, Pradat, Pierre-Francois, Silani, Vincenzo, Tomik, Barbara, Wasner, Maria, Weber, Markus

“…Background:  The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. Objectives:  To provide evidence‐based or…”
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A susceptibility-weighted imaging qualitative score of the motor cortex may be a useful tool for distinguishing clinical phenotypes in amyotrophic lateral sclerosis by Conte, Giorgio, Sbaraini, Sara, Morelli, Claudia, Casale, Silvia, Caschera, Luca, Contarino, Valeria Elisa, Scola, Elisa, Cinnante, Claudia, Trogu, Francesca, Triulzi, Fabio, Silani, Vincenzo

“…Objectives To distinguish amyotrophic lateral sclerosis (ALS) and its subtypes from ALS mimics and healthy controls based on the assessment of iron-related…”
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Long-Lasting Cognitive Abnormalities after COVID-19 by Ferrucci, Roberta, Dini, Michelangelo, Groppo, Elisabetta, Rosci, Chiara, Reitano, Maria Rita, Bai, Francesca, Poletti, Barbara, Brugnera, Agostino, Silani, Vincenzo, D'Arminio Monforte, Antonella, Priori, Alberto

“…Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study the occurrence of cognitive abnormalities in the months…”
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The preferences of people with amyotrophic lateral sclerosis on riluzole treatment in Europe by Ludolph, Albert C., Grandjean, Harish, Reviers, Evy, De Micheli, Valentina, Bianchi, Cosetta, Cardosi, Leonardo, Russ, Hermann, Silani, Vincenzo

“…The Patient Preference Survey aims to understand unmet needs related to riluzole management in people with Amyotrophic Lateral Sclerosis (ALS) and to identify…”
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GRN−/− iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis by Bossolasco, Patrizia, Cimini, Sara, Maderna, Emanuela, Bardelli, Donatella, Canafoglia, Laura, Cavallaro, Tiziana, Ricci, Martina, Silani, Vincenzo, Marucci, Gianluca, Rossi, Giacomina

“…Heterozygous mutations in the gene coding for progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) while homozygous mutations are linked to…”
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Advance care planning and mental capacity in ALS: a current challenge for an unsolved matter by Poletti, Barbara, Carelli, Laura, Lunetta, Christian, Ticozzi, Nicola, Silani, Vincenzo

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Unilateral freezing of gait or “magnetic feet phenomenon” caused by ischemic lesion involving fronto-striatal networks by Lerario, Alberto, Girotti, Floriano, Sassone, Jenny, Poletti, Barbara, Ciammola, Andrea, Silani, Vincenzo

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Testing olfactory dysfunction in acute and recovered COVID-19 patients: a single center study in Italy by Pasquini, Jacopo, Maremmani, Carlo, Salvadori, Stefano, Silani, Vincenzo, Ticozzi, Nicola

“…Background Olfactory dysfunction in coronavirus disease 2019 (COVID-19) is common during acute illness and appears to last longer than other symptoms. The aim…”
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Rising evidence for neurological involvement in COVID-19 pandemic by Calcagno, Narghes, Colombo, Eleonora, Maranzano, Alessio, Pasquini, Jacopo, Keller Sarmiento, Ignacio Juan, Trogu, Francesca, Silani, Vincenzo

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Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis by Iakovleva, Viktoriia, Verde, Federico, Cinnante, Claudia, Sillani, Alessandro, Conte, Giorgio, Corsini, Elena, Ciusani, Emilio, Erbetta, Alessandra, Silani, Vincenzo, Ticozzi, Nicola

“…Bibrachial amyotrophy associated with an extradural CSF collection and infratentorial superficial siderosis (SS) are rare conditions that may occasionally…”
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