Search Results - "Silander, K"

Testing the advantages and disadvantages of short- and long- read eukaryotic metagenomics using simulated reads by Pearman, William S, Freed, Nikki E, Silander, Olin K

“…The first step in understanding ecological community diversity and dynamics is quantifying community membership. An increasingly common method for doing so is…”
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Automated Reconstruction of Whole-Genome Phylogenies from Short-Sequence Reads by Bertels, Frederic, Silander, Olin K., Pachkov, Mikhail, Rainey, Paul B., van Nimwegen, Erik

“…Studies of microbial evolutionary dynamics are being transformed by the availability of affordable high-throughput sequencing technologies, which allow…”
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A genome-wide analysis of promoter-mediated phenotypic noise in Escherichia coli by Silander, Olin K, Nikolic, Nela, Zaslaver, Alon, Bren, Anat, Kikoin, Ilya, Alon, Uri, Ackermann, Martin

“…Gene expression is subject to random perturbations that lead to fluctuations in the rate of protein production. As a consequence, for any given protein,…”
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Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software by Kaiser, Matthias, Jug, Florian, Julou, Thomas, Deshpande, Siddharth, Pfohl, Thomas, Silander, Olin K., Myers, Gene, van Nimwegen, Erik

“…Much is still not understood about how gene regulatory interactions control cell fate decisions in single cells, in part due to the difficulty of directly…”
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predictability of molecular evolution during functional innovation by Blank, Diana, Wolf, Luise, Ackermann, Martin, Silander, Olin K.

“…Determining the molecular changes that give rise to functional innovations is a major unresolved problem in biology. The paucity of examples has served as a…”
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Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in Escherichia coli by Breckell, Georgia L, Silander, Olin K

“…Abstract DNA methylation in bacteria frequently serves as a simple immune system, allowing recognition of DNA from foreign sources, such as phages or selfish…”
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Expression noise facilitates the evolution of gene regulation by Wolf, Luise, Silander, Olin K, van Nimwegen, Erik

“…Although it is often tacitly assumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve from a state without…”
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Understanding the evolutionary fate of finite populations: the dynamics of mutational effects by Silander, Olin K, Tenaillon, Olivier, Chao, Lin

“…The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not…”
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Use of Genomics to Track Coronavirus Disease Outbreaks, New Zealand by Geoghegan, Jemma L, Douglas, Jordan, Ren, Xiaoyun, Storey, Matthew, Hadfield, James, Silander, Olin K, Freed, Nikki E, Jelley, Lauren, Jefferies, Sarah, Sherwood, Jillian, Paine, Shevaun, Huang, Sue, Sporle, Andrew, Baker, Michael G, Murdoch, David R, Drummond, Alexei J, Welch, David, Simpson, Colin R, French, Nigel, Holmes, Edward C, de Ligt, Joep

“…Real-time genomic sequencing has played a major role in tracking the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),…”
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Patterns of evolutionary conservation of essential genes correlate with their compensability by Bergmiller, Tobias, Ackermann, Martin, Silander, Olin K

“…Essential genes code for fundamental cellular functions required for the viability of an organism. For this reason, essential genes are often highly conserved…”
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Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment by Sulit, A. K., Daigneault, M., Allen-Vercoe, E., Silander, O. K., Hock, B., McKenzie, J., Pearson, J., Frizelle, F. A., Schmeier, S., Purcell, R.

“…Immune responses can have opposing effects in colorectal cancer (CRC), the balance of which may determine whether a cancer regresses, progresses, or…”
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Efficiency of the synthetic self‐splicing RiboJ ribozyme is robust to cis‐ and trans‐changes in genetic background by Vlková, Markéta, Morampalli, Bhargava Reddy, Silander, Olin K.

“…The expanding knowledge of the variety of synthetic genetic elements has enabled the construction of new and more efficient genetic circuits and yielded novel…”
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A simple screen to identify promoters conferring high levels of phenotypic noise by Freed, Nikki E, Silander, Olin K, Stecher, Bärbel, Böhm, Alex, Hardt, Wolf-Dietrich, Ackermann, Martin

“…Genetically identical populations of unicellular organisms often show marked variation in some phenotypic traits. To investigate the molecular causes and…”
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Concordant geographic and genetic structure revealed by genotyping‐by‐sequencing in a New Zealand marine isopod by Pearman, William S., Wells, Sarah J., Silander, Olin K., Freed, Nikki E., Dale, James

“…Population genetic structure in the marine environment can be influenced by life‐history traits such as developmental mode (biphasic, with distinct adult and…”
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Long-read sequencing reveals atypical mitochondrial genome structure in a New Zealand marine isopod by Pearman, William S, Wells, Sarah J, Dale, James, Silander, Olin K, Freed, Nikki E

“…Most animal mitochondrial genomes are small, circular and structurally conserved. However, recent work indicates that diverse taxa possess unusual…”
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Genome‐wide association study and meta‐analysis in Northern European populations replicate multiple colorectal cancer risk loci by Tanskanen, Tomas, van den Berg, Linda, Välimäki, Niko, Aavikko, Mervi, Ness‐Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Bexe Lindskog, Elinor, Tõnisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hänninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti‐Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen‐Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka‐Pekka, Al‐Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo, Aaltonen, Lauri A.

“…Genome‐wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in…”
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Epistasis between deleterious mutations and the evolution of recombination by Kouyos, Roger D., Silander, Olin K., Bonhoeffer, Sebastian

“…Epistasis and the evolution of recombination are closely intertwined: epistasis generates linkage disequilibria (i.e. statistical associations between…”
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Replication of restless legs syndrome loci in three European populations by Kemlink, D, Polo, O, Frauscher, B, Gschliesser, V, Högl, B, Poewe, W, Vodicka, P, Vavrova, J, Sonka, K, Nevsimalova, S, Schormair, B, Lichtner, P, Silander, K, Peltonen, L, Gieger, C, Wichmann, H E, Zimprich, A, Roeske, D, Müller-Myhsok, B, Meitinger, T, Winkelmann, J

“…Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p,…”
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Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families by Wedenoja, J, Loukola, A, Tuulio-Henriksson, A, Paunio, T, Ekelund, J, Silander, K, Varilo, T, Heikkilä, K, Suvisaari, J, Partonen, T, Lönnqvist, J, Peltonen, L

“…Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several…”
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P.2.d.001 Neurocognitive impairments in bipolar disorder are restricted to a subgroup of patients by Sparding, T, Silander, K, Hansen, S, Landén, M

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