Search Results - "Sikora, G"

The increasing incidence of thyroid cancer: the influence of access to care by Morris, Luc G T, Sikora, Andrew G, Tosteson, Tor D, Davies, Louise

“…The rapidly rising incidence of papillary thyroid cancer may be due to overdiagnosis of a reservoir of subclinical disease. To conclude that overdiagnosis is…”
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STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy by Leach, David G., Dharmaraj, Neeraja, Piotrowski, Stacey L., Lopez-Silva, Tania L., Lei, Yu L., Sikora, Andrew G., Young, Simon, Hartgerink, Jeffrey D.

“…Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a…”
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The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC) by Cohen, Ezra E W, Bell, R Bryan, Bifulco, Carlo B, Burtness, Barbara, Gillison, Maura L, Harrington, Kevin J, Le, Quynh-Thu, Lee, Nancy Y, Leidner, Rom, Lewis, Rebecca L, Licitra, Lisa, Mehanna, Hisham, Mell, Loren K, Raben, Adam, Sikora, Andrew G, Uppaluri, Ravindra, Whitworth, Fernanda, Zandberg, Dan P, Ferris, Robert L

“…Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000…”
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Second Primary Cancers After an Index Head and Neck Cancer: Subsite-Specific Trends in the Era of Human Papillomavirus–Associated Oropharyngeal Cancer by MORRIS, Luc G. T, SIKORA, Andrew G, PATEL, Snehal G, HAYES, Richard B, GANLY, Ian

“…Patients with head and neck squamous cell carcinoma (HNSCC) are at elevated risk of second primary malignancies (SPM), most commonly of the head and neck (HN),…”
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Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization by Lu, Geming, Zhang, Ruihua, Geng, Shuo, Peng, Liang, Jayaraman, Padmini, Chen, Chun, Xu, Feifong, Yang, Jianjun, Li, Qin, Zheng, Hao, Shen, Kimberly, Wang, Juan, Liu, Xiyu, Wang, Weidong, Zheng, Zihan, Qi, Chen-Feng, Si, Chuanping, He, John Cijiang, Liu, Kebin, Lira, Sergio A., Sikora, Andrew G., Li, Liwu, Xiong, Huabao

“…Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2…”
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Molecular Pathways: Inflammation-Associated Nitric-Oxide Production as a Cancer-Supporting Redox Mechanism and a Potential Therapeutic Target by GRIMM, Elizabeth A, SIKORA, Andrew G, EKMEKCIOGLU, Suhendan

“…It is widely accepted that many cancers express features of inflammation, driven by both microenvironmental cells and factors, and the intrinsic production of…”
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Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments by Carrero, Ivenise, Liu, Hsuan-Chen, Sikora, Andrew G., Milosavljevic, Aleksandar

“…Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer…”
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Predictors of Survival in Mucosal Melanoma of the Head and Neck by Jethanamest, Daniel, Vila, Peter M., Sikora, Andrew G., Morris, Luc G. T.

“…Background The head and neck is the most common site of mucosal melanoma, a cancer with poor prognosis. In contrast to cutaneous melanoma, mucosal melanoma of…”
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Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy by Rangel, Roberto, Pickering, Curtis R, Sikora, Andrew G, Spiotto, Michael T

“…Oral premalignant lesions (OPLs) are the precursors to oral cavity cancers, and have variable rates of progression to invasive disease. As an intermediate…”
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Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release by Jayaraman, Padmini, Parikh, Falguni, Lopez-Rivera, Esther, Hailemichael, Yared, Clark, Amelia, Ma, Ge, Cannan, David, Ramacher, Marcel, Kato, Masashi, Overwijk, Willem W, Chen, Shu-Hsia, Umansky, Viktor Y, Sikora, Andrew G

“…Inducible NO synthase (iNOS) is a hallmark of chronic inflammation that is also overexpressed in melanoma and other cancers. Whereas iNOS is a known effector…”
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Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2 by LOPEZ-RIVERA, Esther, JAYARAMAN, Padmini, AGUIRRE-GHISO, Julio, SIKORA, Andrew G, PARIKH, Falguni, DAVIES, Michael A, EKMEKCIOGLU, Suhendan, IZADMEHR, Sudeh, MILTON, Denái R, CHIPUK, Jerry E, GRIMM, Elizabeth A, ESTRADA, Yeriel

“…Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide synthase (iNOS) is overexpressed in melanoma and other cancers,…”
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Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma by Elhalawani, Hesham, Mohamed, Abdallah S R, Elgohari, Baher, Lin, Timothy A, Sikora, Andrew G, Lai, Stephen Y, Abusaif, Abdelrahman, Phan, Jack, Morrison, William H, Gunn, G Brandon, Rosenthal, David I, Garden, Adam S, Fuller, Clifton D, Sandulache, Vlad C

“…The incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the US is rapidly increasing, driven largely by the epidemic of human papillomavirus…”
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Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer by Parikh, Falguni, Duluc, Dorothée, Imai, Naoko, Clark, Amelia, Misiukiewicz, Krzys, Bonomi, Marcello, Gupta, Vishal, Patsias, Alexis, Parides, Michael, Demicco, Elizabeth G, Zhang, David Y, Kim-Schulze, Seunghee, Kao, Johnny, Gnjatic, Sacha, Oh, Sangkon, Posner, Marshall R, Sikora, Andrew G

“…While viral antigens in human papillomavirus (HPV)-related oropharyngeal cancer (HPVOPC) are attractive targets for immunotherapy, the effects of existing…”
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Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects by Veeramachaneni, Ratna, Yu, Wangjie, Newton, Jared M, Kemnade, Jan O, Skinner, Heath D, Sikora, Andrew G, Sandulache, Vlad C

“…BackgroundMetformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional…”
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Transoral robotic resection and reconstruction for head and neck cancer by Genden, Eric M., Kotz, Tamar, Tong, Charles C. L., Smith, Claris, Sikora, Andrew G., Teng, Marita S., Packer, Stuart H., Lawson, William L., Kao, Johnny

“…Objectives/Hypothesis: To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and…”
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TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy by Jayaraman, Padmini, Parikh, Falguni, Newton, Jared M., Hanoteau, Aurelie, Rivas, Charlotte, Krupar, Rosemarie, Rajapakshe, Kimal, Pathak, Ravi, Kanthaswamy, Kavin, MacLaren, Cassie, Huang, Shixia, Coarfa, Cristian, Spanos, Chad, Edwards, Dean P., Parihar, Robin, Sikora, Andrew G.

“…Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a…”
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Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma by Krupar, Rosemarie, Hautmann, Matthias G., Pathak, Ravi R., Varier, Indu, McLaren, Cassandra, Gaag, Doris, Hellerbrand, Claus, Evert, Matthias, Laban, Simon, Idel, Christian, Sandulache, Vlad, Perner, Sven, Bosserhoff, Anja K., Sikora, Andrew G.

“…Tumor immune microenvironment and tumor metabolism are major determinants of chemoradiotherapy response. The interdependency and prognostic significance of…”
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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy by Hanoteau, Aurelie, Newton, Jared M, Krupar, Rosemarie, Huang, Chen, Liu, Hsuan-Chen, Gaspero, Angelina, Gartrell, Robyn D, Saenger, Yvonne M, Hart, Thomas D, Santegoets, Saskia J, Laoui, Damya, Spanos, Chad, Parikh, Falguni, Jayaraman, Padmini, Zhang, Bing, Van der Burg, Sjoerd H, Van Ginderachter, Jo A, Melief, Cornelis J M, Sikora, Andrew G

“…Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is…”
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Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer by Tong, Charles C. L., Kao, Johnny, Sikora, Andrew G.

“…The estimated annual incidence of oral cavity and pharyngeal cancer is 39,000 in the United States and 260,000 cases worldwide. Despite significant advances in…”
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Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response by Ahmed, Kazi Mokim, Veeramachaneni, Ratna, Deng, Defeng, Putluri, Nagireddy, Putluri, Vasanta, Cardenas, Maria F, Wheeler, David A, Decker, William K, Frederick, Andy I, Kazi, Sawad, Sikora, Andrew G, Sandulache, Vlad C, Frederick, Mitchell J

“…BackgroundThe existence of immunologically ‘cold tumors’ frequently found across a wide spectrum of tumor types represents a significant challenge for cancer…”
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