Search Results - "Sikkema, Hendrik R"

In silico method for selecting residue pairs for single-molecule microscopy and spectroscopy by Sikkema, Hendrik R., Poolman, Bert

“…Obtaining (dynamic) structure related information on proteins is key for understanding their function. Methods as single-molecule Förster Resonance Energy…”
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Cell Fuelling and Metabolic Energy Conservation in Synthetic Cells by Sikkema, Hendrik R., Gaastra, Bauke F., Pols, Tjeerd, Poolman, Bert

“…We are aiming for a blue print for synthesizing (moderately complex) subcellular systems from molecular components and ultimately for constructing life…”
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A synthetic metabolic network for physicochemical homeostasis by Pols, Tjeerd, Sikkema, Hendrik R., Gaastra, Bauke F., Frallicciardi, Jacopo, Śmigiel, Wojciech M., Singh, Shubham, Poolman, Bert

“…One of the grand challenges in chemistry is the construction of functional out-of-equilibrium networks, which are typical of living cells. Building such a…”
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Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins by van 't Klooster, Joury S, Cheng, Tan-Yun, Sikkema, Hendrik R, Jeucken, Aike, Moody, Branch, Poolman, Bert

“…Yeast tolerates a low pH and high solvent concentrations. The permeability of the plasma membrane (PM) for small molecules is low and lateral diffusion of…”
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Heterodimer Formation of the Homodimeric ABC Transporter OpuA by Alvarez-Sieiro, Patricia, Sikkema, Hendrik R., Poolman, Bert

“…Many proteins have a multimeric structure and are composed of two or more identical subunits. While this can be advantageous for the host organism, it can be a…”
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Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA by Sikkema, Hendrik R, van den Noort, Marco, Rheinberger, Jan, de Boer, Marijn, Krepel, Sabrina T, Schuurman-Wolters, Gea K, Paulino, Cristina, Poolman, Bert

“…(Micro)organisms are exposed to fluctuating environmental conditions, and adaptation to stress is essential for survival. Increased osmolality (hypertonicity)…”
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Membrane Lipid Requirements of the Lysine Transporter Lyp1 from Saccharomyces cerevisiae by van 't Klooster, Joury S., Cheng, Tan-Yun, Sikkema, Hendrik R., Jeucken, Aike, Moody, D. Branch, Poolman, Bert

“…Membrane lipids act as solvents and functional cofactors for integral membrane proteins. The yeast plasma membrane is unusual in that it may have a high lipid…”
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