Search Results - "Sikes, R A"

Osteopontin: Possible Role in Prostate Cancer Progression by Thalmann, G N, Sikes, R A, Devoll, R E, Kiefer, J A, Markwalder, R, Klima, I, Farach-Carson, C M, Studer, U E, Chung, L W

“…Human prostate cancer has the propensity to metastasize to the bone where reciprocal cellular interactions between prostate cancer and bone cells are known to…”
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LNCaP progression model of human prostate cancer: Androgen-independence and osseous metastasis by Thalmann, George N., Sikes, Robert A., Wu, Tony T., Degeorges, Armelle, Chang, Shi-Ming, Ozen, Mustafa, Pathak, Sen, Chung, Leland W.K.

“…BACKGROUND Clinically, the lethal phenotypes of human prostate cancer are characterized by their progression to androgen‐independence and their propensity to…”
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Establishing human prostate cancer cell xenografts in bone: Induction of osteoblastic reaction by prostate‐specific antigen‐producing tumors in athymic and SCID/bg mice using LNCaP and lineage‐derived metastatic sublines by Wu, Tony T., Sikes, Robert A., Cui, Quanjun, Thalmann, George N., Kao, Chinghai, Murphy, Cheryl F., Yang, Hua, Zhau, Haiyen E., Balian, Gary, Chung, Leland W. K.

“…LNCaP lineage‐derived human prostate cancer cell lines C4‐2 and C4‐2B4 acquire androgen independence and osseous metastatic potential in vivo. Using C4‐2 and…”
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Suramin-Induced Decrease in Prostate-Specific Antigen Expression With No Effect on Tumor Growth in the LNCaP Model of Human Prostate Cancer by Thalmann, George N., Sikes, Robert A., Chang, Shi-Ming, Johnston, Dennis A., von Eschenbach, Andrew C., Chung, Leland W. K.

“…Background: Suramin, a polysulfonated naphthylurea and a recognized antitrypanosomal agent, has shown some promise in phase II clinical trials in the…”
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Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models by KO, S.-C, CHEON, J, KAO, C, GOTOH, A, SHIRAKAWA, T, SIKES, R. A, KARSENTY, G, CHUNG, L. W. K

“…Osteocalcin (OC), a noncollagenous bone matrix protein, is expressed in high levels by osteoblasts. To determine whether the OC promoter mediates cell-specific…”
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The accuracy of selective magnetic resonance imaging compared with the findings of arthroscopy of the knee by Polly, D W, Callaghan, J J, Sikes, R A, McCabe, J M, McMahon, K, Savory, C G

“…The results of selective magnetic resonance imaging of the knee were compared with those of arthroscopy in a prospective series of fifty patients. A…”
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Human prostate cancer expresses the low affinity insulin-like growth factor binding protein IGFBP-rP1 by DEGEORGES, A, FUAN WANG, FRIERSON, H. F, SETH, A, CHUNG, L. W. K, SIKES, R. A

“…Many of the alterations in the insulin-like growth factor (IGF) axis in prostatic disease have been associated with changes in the insulin-like growth factor…”
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Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer by Hyytinen, Eija-Riitta, Frierson Jr, Henry F., Sipe, Tavis W., Li, Chang-Ling, Degeorges, Armelle, Sikes, Robert A., Chung, Leland W.K., Dong, Jin-Tang

“…BACKGROUND Three regions of chromosome 13 were previously identified for having loss of heterozygosity (LOH) in human prostate cancer. One of them, at 13q33,…”
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Transfected neu oncogene induces human prostate cancer metastasis by Zhau, Haiyen Y. E., Zhou, Jianxin, Symmans, W. Fraser, Chen, Bao-Qi, Chang, Shi-Ming, Sikes, Robert A., Chung, Leland W. K.

“…c‐erb B2/neu has been demonstrated to be a transforming oncogene in both rodent and human prostatic epithelial cells. To understand the potential role of neu…”
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Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens by Chen, M E, Lin, S H, Chung, L W, Sikes, R A

“…The LNCaP progression model of human prostate cancer consists of lineage-related sublines that differ in their androgen sensitivity and metastatic potential. A…”
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Distribution of IGFBP-rP1 in Normal Human Tissues by Degeorges, Armelle, Wang, Fuan, Frierson, Henry F., , Jr, Seth, Arun, Sikes, Robert A

“…IGFBP-rP1/mac25 is a recently described member of the insulin-like growth factor binding protein (IGFBP) family. It has structural homology to the other…”
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A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans by Cleutjens, K B, van der Korput, H A, Ehren-van Eekelen, C C, Sikes, R A, Fasciana, C, Chung, L W, Trapman, J

“…Prostate-specific antigen (PSA) is a kallikrein-like serine protease, which is almost exclusively synthesized in the luminal epithelial cells of the human…”
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Inhibition of experimentally induced mouse prostatic hyperplasia by castration or steroid antagonist administration by Sikes, R A, Thomsen, S, Petrow, V, Neubauer, B L, Chung, L W

“…Mouse prostatic hyperplasia has been induced experimentally by implanting fetal urogenital sinus tissue into the prostate gland of syngeneic mice. We compared…”
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Photodynamic therapy with photofrin II induces programmed cell death in carcinoma cell lines by He, X Y, Sikes, R A, Thomsen, S, Chung, L W, Jacques, S L

“…The mode of cell death following photodynamic therapy was investigated from the perspective of programmed cell death or apoptosis. Human prostate carcinoma…”
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Molecular determination of surgical margins using fossa biopsies at radical prostatectomy by Theodorescu, D, Frierson, Jr, H F, Sikes, R A

“…Status of the surgical margins after radical prostatectomy is a key factor for predicting postoperative outcome. Current methods used to determine margin…”
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Chemistry and pharmacology of anticancer drugs by Sikes, R A

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Integrin expression and usage by prostate cancer cell lines on laminin substrata by EDLUND, Magnus, MIYAMOTO, Tadayuki, SIKES, Robert A, OGLE, Roy, LAURIE, Gordon W, FARACH-CARSON, Mary C, OTEY, Carol A, ZHAU, Haiyen E, CHUNG, Leland W. K

“…During prostate cancer progression, invasive glandular epithelial cells move out of the ductal-acinar architecture and through the surrounding basement…”
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Comparison of the Deduced Amino Acid Sequence of Guinea Pig Adenovirus Hexon Protein with That of Other Mastadenoviruses by Feldman, Sanford H., Sikes, Robert A., Eckhoff, Gary A.

“…Purpose: We sought to isolate, clone, and determine the nucleic acid sequence of the guinea pig adenovirus (GPAdV) hexon gene. From this, the amino acid…”
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Acquisition of a tumorigenic phenotype by a rat ventral prostate epithelial cell line expressing a transfected activated neu oncogene by Sikes, R A, Chung, L W

“…The neu oncogene has been demonstrated to be a potent transforming gene in rodent fibroblasts. The overexpression of the human erbB-2/neu oncogene has been…”
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Abstract P2-09-20: 2’(3’)-O-(4-benzoylbenzoyl)adenosine 5’-triphosphate (BzATP) is a potential drug for triple negative breast cancer: Autophagy and apoptosis inducer by Lertsuwan, J, Sikes, RA

“…Triple-negative breast cancer (TNBC) is among the most aggressive and therapy resistant type of breast cancer. New therapeutic strategies and new treatments…”
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