Search Results - "Sikes, James"

A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice by Sadler, Daniel G, Treas, Lillie, Sikes, James D, Porter, Craig

“…Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in part to uncoupling protein-1 (UCP1). The impact of…”
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Restoration of anterior regeneration in a planarian with limited regenerative ability by Sikes, James M., Newmark, Phillip A.

“…Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; this study of…”
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Western Diet Modifies Platelet Activation Profiles in Male Mice by Corken, Adam, Wahl, Elizabeth C, Sikes, James D, Thakali, Keshari M

“…The correlation between obesity and cardiovascular disease has long been understood, yet scant investigations endeavored to determine the impact of an…”
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Latent regeneration abilities persist following recent evolutionary loss in asexual annelids by Bely, Alexandra E, Sikes, James M

“…Regeneration abilities have been repeatedly lost in many animal phyla. However, because regeneration research has focused almost exclusively on highly…”
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Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection by Nagarajan, Uma M, Sikes, James D, Yeruva, Laxmi, Prantner, Daniel

“…IL-1β has been implicated in the development of oviduct pathology during Chlamydia muridarum genital infection in the mouse model. The goal of this study was…”
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Parental cardiorespiratory fitness influences early life energetics and metabolic health by Sadler, Daniel G, Treas, Lillie, Ross, Taylor, Sikes, James D, Britton, Steven L, Koch, Lauren G, Piccolo, Brian D, Børsheim, Elisabet, Porter, Craig

“…High cardiorespiratory fitness (CRF) is associated with a reduced risk of metabolic disease and is linked to superior mitochondrial respiratory function. This…”
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Coordinated wound responses in a regenerative animal-algal holobiont by Nanes Sarfati, Dania, Xue, Yuan, Song, Eun Sun, Byrne, Ashley, Le, Daniel, Darmanis, Spyros, Quake, Stephen R., Burlacot, Adrien, Sikes, James, Wang, Bo

“…Animal regeneration involves coordinated responses across cell types throughout the animal body. In endosymbiotic animals, whether and how symbionts react to…”
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Protonophore treatment augments energy expenditure in mice housed at thermoneutrality by Sadler, Daniel G, Landes, Reid D, Treas, Lillie, Sikes, James, Porter, Craig

“…Sub-thermoneutral housing increases facultative thermogenesis in mice, which may mask the pre-clinical efficacy of anti-obesity strategies that target energy…”
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Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice by Paz, Henry A., Buddha, Lasya, Zhong, Ying, Sikes, James D., Wankhade, Umesh D.

“…Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role in shaping offspring microbiome composition…”
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Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices by Kennedy, Joshua L., Koziol-White, Cynthia J., Jeffus, Susanne, Rettiganti, Mallikarjuna R., Fisher, Paige, Kurten, Megan, Eze, Anthony, House, Suzanne, Sikes, James D., Askew, Emily, Putt, Claire, Panettieri, Reynold A., Jones, Stacie M., Kurten, Richard C.

“…A subset of the PCLS was then infected with RV39, with uninfected PCLS providing controls. Because PCLS airways frequently exhibit basal tone (data not shown),…”
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Regeneration in spiralians: evolutionary patterns and developmental processes by Bely, Alexandra E, Zattara, Eduardo E, Sikes, James M

“…Animals differ markedly in their ability to regenerate, yet still little is known about how regeneration evolves. In recent years, important advances have been…”
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Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis by Nagarajan, Uma M., Sikes, James D., Burris, Ramona L., Jha, Rajneesh, Popovic, Branimir, Fraungruber, Pamelia, Hennings, Leah, Haggerty, Catherine L., Nagarajan, Shanmugam

“…Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of…”
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Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model by Gurung, Manoj, Rosa, Fernanda, Yelvington, Brooke, Terry, Nathan, Read, Quentin D, Piccolo, Brian D, Moody, Becky, Tripp, Patricia, Pittman, 3rd, Hoy E, Fay, Bobby L, Ross, Talyor J, Sikes, James D, Flowers, Jessica B, Fox, Renee, LeRoith, Tanya, Talatala, Rachelanne, Bar-Yoseph, Fabiana, Yeruva, Laxmi

“…A controlled-neonatal piglet trial was conducted to evaluate the impact of a plant-based infant formula containing buckwheat and almonds as the main source of…”
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Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge by Paz, Henry A, Pilkington, Anna-Claire, Zhong, Ying, Chintapalli, Sree V, Sikes, James, Lan, Renny S, Shankar, Kartik, Wankhade, Umesh D

“…The gut microbiota plays a critical role in energy homeostasis and its dysbiosis is associated with obesity. Maternal high-fat diet (HFD) and β-adrenergic…”
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Evaluation of the Safety of a Plant-Based Infant Formula Containing Almonds and Buckwheat in a Neonatal Piglet Model by Rosa, Fernanda, Yelvington, Brooke, Terry, Nathan, Tripp, Patricia, Pittman, 3rd, Hoy E, Fay, Bobby L, Ross, Taylor J, Sikes, James D, Flowers, Jessica B, Bar-Yoseph, Fabiana, Yeruva, Laxmi

“…A randomized neonatal piglet trial was conducted to evaluate the safety and the effects of a plant-based formula containing almonds and buckwheat as the main…”
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Critical Role for Interleukin-1β (IL-1β) during Chlamydia muridarum Genital Infection and Bacterial Replication-Independent Secretion of IL-1β in Mouse Macrophages by Prantner, Daniel, Darville, Toni, Sikes, James D, Andrews, Charles W. Jr, Brade, Helmut, Rank, Roger G, Nagarajan, Uma M

“…Recent findings have implicated interleukin-1β (IL-1β) as an important mediator of the inflammatory response in the female genital tract during chlamydial…”
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Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model by Nagarajan, Uma M, Prantner, Daniel, Sikes, James D, Andrews, Charles W. Jr, Goodwin, Anna M, Nagarajan, Shanmugam, Darville, Toni

“…Type I interferons (IFNs) induced during in vitro chlamydial infection exert bactericidal and immunomodulatory functions. To determine the precise role of type…”
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Making heads from tails: Development of a reversed anterior–posterior axis during budding in an acoel by Sikes, James M., Bely, Alexandra E.

“…The anterior–posterior axis is a key feature of the bilaterian body plan. Although axis specification during embryogenesis has been studied extensively,…”
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IL-33 and IL-13 Receptors Are Upregulated in Precision Cut Lung Slices from Donors with Asthma during RV39 Infection by Waldron, Jamie L, Currey, Dorothy J, House, Suzanne E, Sikes, James D, Jones, Stacie M, Kurten, Richard, Kennedy, Joshua, MD

“…Expression was normalized to beta-actin and uninfected tissue from the same lung and the same time point…”
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C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying Lachnoclostridium [clostridium] scindens in mice by Adams, Sean H., Wright, Rachel, Piccolo, Brian D., Moody, Becky, Sikes, James, Avaritt, Nathan, Chintapalli, Sree V., Ou, Xiawei

“…In humans and animal models, Cesarean section (C‐section) has been associated with alterations in the taxonomic structure of the gut microbiome. These changes…”
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