Search Results - "Sijmonsma, Tjeerd P."

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart by Jabs, Markus, Rose, Adam J, Lehmann, Lorenz H, Taylor, Jacqueline, Moll, Iris, Sijmonsma, Tjeerd P, Herberich, Stefanie E, Sauer, Sven W, Poschet, Gernot, Federico, Giuseppina, Mogler, Carolin, Weis, Eva-Maria, Augustin, Hellmut G, Yan, Minhong, Gretz, Norbert, Schmid, Roland M, Adams, Ralf H, Gröne, Hermann-Joseph, Hell, Rüdiger, Okun, Jürgen G, Backs, Johannes, Nawroth, Peter P, Herzig, Stephan, Fischer, Andreas

“…BACKGROUND:Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of…”
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Browning of white adipose tissue uncouples glucose uptake from insulin signaling by Mössenböck, Karin, Vegiopoulos, Alexandros, Rose, Adam J, Sijmonsma, Tjeerd P, Herzig, Stephan, Schafmeier, Tobias

“…Presence of thermogenically active adipose tissue in adult humans has been inversely associated with obesity and type 2 diabetes. While it had been shown that…”
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Brown adipose tissue harbors a distinct sub-population of regulatory T cells by Medrikova, Dasa, Sijmonsma, Tjeerd P, Sowodniok, Katharina, Richards, David M, Delacher, Michael, Sticht, Carsten, Gretz, Norbert, Schafmeier, Tobias, Feuerer, Markus, Herzig, Stephan

“…Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells…”
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Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 by Ekim Üstünel, Bilgen, Friedrich, Kilian, Maida, Adriano, Wang, Xiaoyue, Krones-Herzig, Anja, Seibert, Oksana, Sommerfeld, Anke, Jones, Allan, Sijmonsma, Tjeerd P., Sticht, Carsten, Gretz, Norbert, Fleming, Thomas, Nawroth, Peter P., Stremmel, Wolfgang, Rose, Adam J., Berriel-Diaz, Mauricio, Blüher, Matthias, Herzig, Stephan

“…Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and…”
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Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease by Hakroush, Samy, Moeller, Marcus J, Theilig, Franziska, Kaissling, Brigitte, Sijmonsma, Tjeerd P, Jugold, Manfred, Akeson, Ann L, Traykova-Brauch, Milena, Hosser, Hiltraud, Hähnel, Brunhilde, Gröne, Hermann-Josef, Koesters, Robert, Kriz, Wilhelm

“…The role of vascular endothelial growth factor (VEGF) in renal fibrosis, tubular cyst formation, and glomerular diseases is incompletely understood. We studied…”
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Transcriptional Cofactor TBLR1 Controls Lipid Mobilization in White Adipose Tissue by Rohm, Maria, Sommerfeld, Anke, Strzoda, Daniela, Jones, Allan, Sijmonsma, Tjeerd P., Rudofsky, Gottfried, Wolfrum, Christian, Sticht, Carsten, Gretz, Norbert, Zeyda, Maximilian, Leitner, Lukas, Nawroth, Peter P., Stulnig, Thomas M., Diaz, Mauricio Berriel, Vegiopoulos, Alexandros, Herzig, Stephan

“…Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of…”
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Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health by Fuhrmeister, Jessica, Zota, Annika, Sijmonsma, Tjeerd P, Seibert, Oksana, Cıngır, Şahika, Schmidt, Kathrin, Vallon, Nicola, de Guia, Roldan M, Niopek, Katharina, Berriel Diaz, Mauricio, Maida, Adriano, Blüher, Matthias, Okun, Jürgen G, Herzig, Stephan, Rose, Adam J

“…Recent studies have demonstrated that repeated short‐term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and…”
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A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice by Dihlmann, Susanne, Böckler, Dittmar, Herzig, Stephan, Sijmonsma, Tjeerd P., Peters, Andreas S., Fleming, Thomas H., Hakimi, Maani, Wortmann, Markus, Nawroth, Peter Paul

“…Objective. Glyoxalase-1 is an enzyme detoxifying methylglyoxal (MG). MG is a potent precursor of advanced glycation endproducts which are regarded to be a key…”
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Novel Class of Glycosphingolipids Involved in Male Fertility by Sandhoff, Roger, Geyer, Rudolf, Jennemann, Richard, Paret, Claudia, Kiss, Eva, Yamashita, Tadashi, Gorgas, Karin, Sijmonsma, Tjeerd P., Iwamori, Masao, Finaz, Catherine, Proia, Richard L., Wiegandt, Herbert, Gröne, Hermann-Josef

“…Mice require testicular glycosphingolipids (GSLs) for proper spermatogenesis. Mutant mice strains deficient in specific genes encoding biosynthetic enzymes of…”
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A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution by Maida, Adriano, Zota, Annika, Sjøberg, Kim A, Schumacher, Jonas, Sijmonsma, Tjeerd P, Pfenninger, Anja, Christensen, Marie M, Gantert, Thomas, Fuhrmeister, Jessica, Rothermel, Ulrike, Schmoll, Dieter, Heikenwälder, Mathias, Iovanna, Juan L, Stemmer, Kerstin, Kiens, Bente, Herzig, Stephan, Rose, Adam J

“…Dietary protein intake is linked to an increased incidence of type 2 diabetes (T2D). Although dietary protein dilution (DPD) can slow the progression of some…”
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Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes by VAN VENROOIJ, Francine V, STOLK, Ronald P, BANGA, Jan-Dirk, SIJMONSMA, Tjeerd P, VAN TOL, Arie, ERKELENS, D. Willem, DALLINGA-THIE, Geesje M

“…Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes Francine V. van Venrooij , MD, PHD 1 2 ,…”
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Sulfated Glycosphingolipid as Mediator of Phagocytosis: SM4s Enhances Apoptotic Cell Clearance and Modulates Macrophage Activity by Popovic, Zoran V, Sandhoff, Roger, Sijmonsma, Tjeerd P, Kaden, Sylvia, Jennemann, Richard, Kiss, Eva, Tone, Edgar, Autschbach, Frank, Platt, Nick, Malle, Ernst, Grone, Hermann-Josef

“…Sulfoglycolipids are present on the surface of a variety of cells. The sulfatide SM4s is increased in lung, renal, and colon cancer and is associated with an…”
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An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice by Rohm, Maria, Schäfer, Michaela, Laurent, Victor, Üstünel, Bilgen Ekim, Niopek, Katharina, Algire, Carolyn, Hautzinger, Oksana, Sijmonsma, Tjeerd P, Zota, Annika, Medrikova, Dasa, Pellegata, Natalia S, Ryden, Mikael, Kulyte, Agné, Dahlman, Ingrid, Arner, Peter, Petrovic, Natasa, Cannon, Barbara, Amri, Ez-Zoubir, Kemp, Bruce E, Steinberg, Gregory R, Janovska, Petra, Kopecky, Jan, Wolfrum, Christian, Blüher, Matthias, Berriel Diaz, Mauricio, Herzig, Stephan

“…Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models…”
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Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control by Jiang, Yang, Rose, Adam J, Sijmonsma, Tjeerd P, Bröer, Angelika, Pfenninger, Anja, Herzig, Stephan, Schmoll, Dieter, Bröer, Stefan

“…Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion…”
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Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control by Jiang, Yang, Rose, Adam J., Sijmonsma, Tjeerd P., Bröer, Angelika, Pfenninger, Anja, Herzig, Stephan, Schmoll, Dieter, Bröer, Stefan

“…Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion…”
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Hepatic transforming growth factor-β 1 stimulated clone-22 D1 controls systemic cholesterol metabolism by Jäger, Julia, Greiner, Vera, Strzoda, Daniela, Seibert, Oksana, Niopek, Katharina, Sijmonsma, Tjeerd P, Schäfer, Michaela, Jones, Allan, De Guia, Roldan, Martignoni, Marc, Dallinga-Thie, Geesje M, Diaz, Mauricio B, Hofmann, Thomas G, Herzig, Stephan

“…Abstract Disturbances in lipid homeostasis are hallmarks of severe metabolic disorders and their long-term complications, including obesity, diabetes, and…”
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Chemokines bind to sulfatides as revealed by surface plasmon resonance by Sandhoff, Roger, Grieshaber, Heike, Djafarzadeh, Roghieh, Sijmonsma, Tjeerd P., Proudfoot, Amanda E.I., Handel, Tracy M., Wiegandt, Herbert, Nelson, Peter J., Gröne, Hermann-Josef

“…Chemokines bind to sulfated cell surface glycosaminoglycans and thereby modulate signaling mediated by G-protein-coupled seven-transmembrane domain chemokine…”
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Fasting‐induced liver GADD 45β restrains hepatic fatty acid uptake and improves metabolic health by Fuhrmeister, Jessica, Zota, Annika, Sijmonsma, Tjeerd P, Seibert, Oksana, Cıngır, Şahika, Schmidt, Kathrin, Vallon, Nicola, de Guia, Roldan M, Niopek, Katharina, Berriel Diaz, Mauricio, Maida, Adriano, Blüher, Matthias, Okun, Jürgen G, Herzig, Stephan, Rose, Adam J

“…Recent studies have demonstrated that repeated short‐term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and…”
Get full text

Mice lacking neutral amino acid transporter B0 AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control by Jiang, Yang, Rose, Adam J, Sijmonsma, Tjeerd P, Bröer, Angelika, Pfenninger, Anja, Herzig, Stephan, Schmoll, Dieter, Bröer, Stefan

“…Abstract Objective Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic…”
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Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells: e0118534 by Medrikova, Dasa, Sijmonsma, Tjeerd P, Sowodniok, Katharina, Richards, David M, Delacher, Michael, Sticht, Carsten, Gretz, Norbert, Schafmeier, Tobias, Feuerer, Markus, Herzig, Stephan

“…Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells…”
Get full text