Search Results - "Sijben, Hubert J."

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery by Sijben, Hubert J., van den Berg, Julie J. E., Broekhuis, Jeremy D., IJzerman, Adriaan P., Heitman, Laura H.

“…Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays…”
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MPP + -Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition by Mocking, Tamara A M, Sijben, Hubert J, Vermeulen, Yimé W, IJzerman, Adriaan P, Heitman, Laura H

“…The organic cation transporters OCT1-3 ( ) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and…”
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Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors by Sijben, Hubert J., van Oostveen, Wieke M., Hartog, Peter B. R., Stucchi, Laura, Rossignoli, Andrea, Maresca, Giovanna, Scarabottolo, Lia, IJzerman, Adriaan P., Heitman, Laura H.

“…The human norepinephrine transporter (NET) is an established drug target for a wide range of psychiatric disorders. Conventional methods that are used to…”
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Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters by Sijben, Hubert J, Dall' Acqua, Laura, Liu, Rongfang, Jarret, Abigail, Christodoulaki, Eirini, Onstein, Svenja, Wolf, Gernot, Verburgt, Simone J, Le Dévédec, Sylvia E, Wiedmer, Tabea, Superti-Furga, Giulio, IJzerman, Adriaan P, Heitman, Laura H

“…Excitatory amino acid transporters (EAAT/SLC1) mediate Na -dependent uptake of extracellular glutamate and are potential drug targets for neurological…”
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Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3 ) variants using in silico and in vitro approaches by Gorostiola González, Marina, Sijben, Hubert J, Dall' Acqua, Laura, Liu, Rongfang, IJzerman, Adriaan P, Heitman, Laura H, van Westen, Gerard J P

“…Glutamate is an essential excitatory neurotransmitter and an intermediate for energy metabolism. Depending on the tumor site, cancer cells have increased or…”
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Targeting solute carriers to modulate receptor–ligand interactions by Sijben, Hubert J., Superti-Furga, Giulio, IJzerman, Adriaan P., Heitman, Laura H.

“…Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of…”
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An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters by Dvorak, Vojtech, Wiedmer, Tabea, Ingles-Prieto, Alvaro, Altermatt, Patrick, Batoulis, Helena, Bärenz, Felix, Bender, Eckhard, Digles, Daniela, Dürrenberger, Franz, Heitman, Laura H, IJzerman, Adriaan P, Kell, Douglas B, Kickinger, Stefanie, Körzö, Daniel, Leippe, Philipp, Licher, Thomas, Manolova, Vania, Rizzetto, Riccardo, Sassone, Francesca, Scarabottolo, Lia, Schlessinger, Avner, Schneider, Vanessa, Sijben, Hubert J, Steck, Anna-Lena, Sundström, Hanna, Tremolada, Sara, Wilhelm, Maria, Wright Muelas, Marina, Zindel, Diana, Steppan, Claire M, Superti-Furga, Giulio

“…The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and…”
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Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays by van Veggel, Lieve, Mocking, Tamara A.M., Sijben, Hubert J., Liu, Rongfang, Gorostiola González, Marina, Dilweg, Majlen A., Royakkers, Jeroen, Li, Anna, Kumar, Vijay, Dong, Yin Yao, Bullock, Alex, Sauer, David B., Diliën, Hanne, van Westen, Gerard J.P., Schreiber, Rudy, Heitman, Laura H., Vanmierlo, Tim

“…Excitatory amino acid transporters (EAATs) are important regulators of amino acid transport and in particular glutamate. Recently, more interest has arisen in…”
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Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily by Digles, Daniela, Ingles-Prieto, Alvaro, Dvorak, Vojtech, Mocking, Tamara A M, Goldmann, Ulrich, Garofoli, Andrea, Homan, Evert J, Di Silvio, Alberto, Azzollini, Lucia, Sassone, Francesca, Fogazza, Mario, Bärenz, Felix, Pommereau, Antje, Zuschlag, Yasmin, Ooms, Jasper F, Tranberg-Jensen, Jeppe, Hansen, Jesper S, Stanka, Josefina, Sijben, Hubert J, Batoulis, Helena, Bender, Eckhard, Martini, Riccardo, IJzerman, Adriaan P, Sauer, David B, Heitman, Laura H, Manolova, Vania, Reinhardt, Juergen, Ehrmann, Alexander, Leippe, Philipp, Ecker, Gerhard F, Huber, Kilian V M, Licher, Thomas, Scarabottolo, Lia, Wiedmer, Tabea, Superti-Furga, Giulio

“…With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and…”
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