Search Results - "Sihto, Harri"

Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy by Bychkov, Dmitrii, Linder, Nina, Tiulpin, Aleksei, Kücükel, Hakan, Lundin, Mikael, Nordling, Stig, Sihto, Harri, Isola, Jorma, Lehtimäki, Tiina, Kellokumpu-Lehtinen, Pirkko-Liisa, von Smitten, Karl, Joensuu, Heikki, Lundin, Johan

“…The treatment of patients with ERBB2 (HER2)-positive breast cancer with anti- ERBB2 therapy is based on the detection of ERBB2 gene amplification or protein…”
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UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma by Puttonen, Maya, Isola, Jorma, Ylinen, Onni, Böhling, Tom, Koljonen, Virve, Sihto, Harri

“…Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light…”
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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy by Haikala, Heidi M., Anttila, Johanna M., Marques, Elsa, Raatikainen, Tiina, Ilander, Mette, Hakanen, Henna, Ala-Hongisto, Hanna, Savelius, Mariel, Balboa, Diego, Von Eyss, Bjoern, Eskelinen, Vilja, Munne, Pauliina, Nieminen, Anni I., Otonkoski, Timo, Schüler, Julia, Laajala, Teemu D., Aittokallio, Tero, Sihto, Harri, Mattson, Johanna, Heikkilä, Päivi, Leidenius, Marjut, Joensuu, Heikki, Mustjoki, Satu, Kovanen, Panu, Eilers, Martin, Leverson, Joel D., Klefström, Juha

“…Elevated MYC expression sensitizes tumor cells to apoptosis but the therapeutic potential of this mechanism remains unclear. We find, in a model of MYC-driven…”
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L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling by Jacquemet, Guillaume, Baghirov, Habib, Georgiadou, Maria, Sihto, Harri, Peuhu, Emilia, Cettour-Janet, Pierre, He, Tao, Perälä, Merja, Kronqvist, Pauliina, Joensuu, Heikki, Ivaska, Johanna

“…Mounting in vitro , in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput…”
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2 by Pietilä, Mika, Sahgal, Pranshu, Peuhu, Emilia, Jäntti, Niklas Z., Paatero, Ilkka, Närvä, Elisa, Al-Akhrass, Hussein, Lilja, Johanna, Georgiadou, Maria, Andersen, Olav M., Padzik, Artur, Sihto, Harri, Joensuu, Heikki, Blomqvist, Matias, Saarinen, Irena, Boström, Peter J., Taimen, Pekka, Ivaska, Johanna

“…The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal…”
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Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial by Joensuu, Heikki, Eriksson, Mikael, Sundby Hall, Kirsten, Reichardt, Annette, Hartmann, Jörg T, Pink, Daniel, Ramadori, Giuliano, Hohenberger, Peter, Al-Batran, Salah-Eddin, Schlemmer, Marcus, Bauer, Sebastian, Wardelmann, Eva, Nilsson, Bengt, Sihto, Harri, Bono, Petri, Kallio, Raija, Junnila, Jouni, Alvegård, Thor, Reichardt, Peter

“…Three years of adjuvant imatinib therapy are recommended for patients with GI stromal tumor (GIST) with high-risk features, according to survival findings in…”
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LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers by Sundqvist, Benjamin, Sihto, Harri, von Willebrand, Maria, Böhling, Tom, Koljonen, Virve

“…Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin. The cell of origin of MCC is thus far unknown and proposed cells of…”
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Transcriptomic analyses reveal three distinct molecular subgroups of Merkel cell carcinoma with differing prognoses by Sundqvist, Benjamin Z., Kilpinen, Sami K., Böhling, Tom O., Koljonen, Virve S. K., Sihto, Harri J.

“…Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy with a poor prognosis and an unknown cell of origin. Proffered cells of origin include…”
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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription by Kaukonen, Riina, Mai, Anja, Georgiadou, Maria, Saari, Markku, De Franceschi, Nicola, Betz, Timo, Sihto, Harri, Ventelä, Sami, Elo, Laura, Jokitalo, Eija, Westermarck, Jukka, Kellokumpu-Lehtinen, Pirkko-Liisa, Joensuu, Heikki, Grenman, Reidar, Ivaska, Johanna

“…Tissue homeostasis is dependent on the controlled localization of specific cell types and the correct composition of the extracellular stroma. While the role…”
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Neurocan expression associates with better survival and viral positivity in Merkel cell carcinoma by Salmikangas, Marko, Laaksonen, Maria, Edgren, Henrik, Salgado, Marco, Suoranta, Anu, Mattila, Pirkko, Koljonen, Virve, Böhling, Tom, Sihto, Harri

“…Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that is frequently divided into Merkel cell polyomavirus negative and positive tumors…”
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ALK is frequently phosphorylated in Merkel cell carcinoma and associates with longer survival by Jaatinen, Jenni, Veija, Tuukka, Salmikangas, Marko, Böhling, Tom, Sihto, Harri, Koljonen, Virve

“…Merkel cell carcinoma (MCC) is a rare skin cancer with only limited therapeutic options for advanced disease. We previously showed that oncogene ALK is…”
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Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study by SIHTO, Harri, BÖHLING, Tom, KAVOLA, Heli, KOLJONEN, Virve, SALMI, Marko, JALKANEN, Sirpa, JOENSUU, Heikki

“…Merkel cell carcinoma (MCC) is a rare skin cancer that often harbors Merkel cell polyomavirus (MCPyV) DNA. The clinical importance of intratumoral immune cells…”
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Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis by Arjonen, Antti, Kaukonen, Riina, Mattila, Elina, Rouhi, Pegah, Högnäs, Gunilla, Sihto, Harri, Miller, Bryan W, Morton, Jennifer P, Bucher, Elmar, Taimen, Pekka, Virtakoivu, Reetta, Cao, Yihai, Sansom, Owen J, Joensuu, Heikki, Ivaska, Johanna

“…Mutations of the tumor suppressor TP53 are present in many forms of human cancer and are associated with increased tumor cell invasion and metastasis. Several…”
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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study by Sihto, Harri, Lundin, Johan, Lundin, Mikael, Lehtimäki, Tiina, Ristimäki, Ari, Holli, Kaija, Sailas, Liisa, Kataja, Vesa, Turpeenniemi-Hujanen, Taina, Isola, Jorma, Heikkilä, Päivi, Joensuu, Heikki

“…Some molecular subtypes of breast cancer have preferential sites of distant relapse. The protein expression pattern of the primary tumor may influence the…”
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Eccrine Porocarcinoma: Clinical and Histopathological Study of 14 Patients with Special Emphasis on Sentinel Lymph Node Biopsy by Meriläinen, Anna-Stiina, Von Willenbrand-Bäckmann, Maria, Sihto, Harri, Koljonen, Virve

“…Eccrine porocarcinoma is a rare skin adnexal tumour that affects elderly people. Most eccrine porocarcinomas are stage I or II according to the American Joint…”
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Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization by Le Joncour, Vadim, Filppu, Pauliina, Hyvönen, Maija, Holopainen, Minna, Turunen, S Pauliina, Sihto, Harri, Burghardt, Isabel, Joensuu, Heikki, Tynninen, Olli, Jääskeläinen, Juha, Weller, Michael, Lehti, Kaisa, Käkelä, Reijo, Laakkonen, Pirjo

“…The current clinical care of glioblastomas leaves behind invasive, radio‐ and chemo‐resistant cells. We recently identified mammary‐derived growth inhibitor…”
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The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma by Rasheed, Kashif, Moens, Ugo, Policastro, Benedetta, Johnsen, John Inge, Koljonen, Virve, Sihto, Harri, Lui, Weng-Onn, Sveinbjørnsson, Baldur

“…Merkel cell polyomavirus (MCPyV) is a causal factor in Merkel cell carcinoma (MCC). The oncogenic potential is mediated through its viral oncoproteins large…”
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Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment by Ihle, Michaela Angelika, Huss, Sebastian, Jeske, Wiebke, Hartmann, Wolfgang, Merkelbach-Bruse, Sabine, Schildhaus, Hans-Ulrich, Büttner, Reinhard, Sihto, Harri, Sundby Hall, Kirsten, Eriksson, Mikael, Reichardt, Peter, Joensuu, Heikki, Wardelmann, Eva

“…Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the…”
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Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1 by Laine, Anni, Sihto, Harri, Come, Christophe, Rosenfeldt, Mathias T, Zwolinska, Aleksandra, Niemelä, Minna, Khanna, Anchit, Chan, Edward K, Kähäri, Veli-Matti, Kellokumpu-Lehtinen, Pirkko-Liisa, Sansom, Owen J, Evan, Gerard I, Junttila, Melissa R, Ryan, Kevin M, Marine, Jean-Christophe, Joensuu, Heikki, Westermarck, Jukka

“…Senescence induction contributes to cancer therapy responses and is crucial for p53-mediated tumor suppression. However, whether p53 inactivation actively…”
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Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy by Haikala, Heidi M., Anttila, Johanna M., Marques, Elsa, Raatikainen, Tiina, Ilander, Mette, Hakanen, Henna, Ala-Hongisto, Hanna, Savelius, Mariel, Balboa, Diego, Von Eyss, Bjoern, Eskelinen, Vilja, Munne, Pauliina, Nieminen, Anni I., Otonkoski, Timo, Schüler, Julia, Laajala, Teemu D., Aittokallio, Tero, Sihto, Harri, Mattson, Johanna, Heikkilä, Päivi, Leidenius, Marjut, Joensuu, Heikki, Mustjoki, Satu, Kovanen, Panu, Eilers, Martin, Leverson, Joel D., Klefström, Juha

“…The original version of this Article contained an error in Fig. 7. In panel b, the survival curves were shifted relative to the y axis. This error has been…”
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