Search Results - "Sigurdardottir, A. G"

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  1. 1
    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding

    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding by Sigurdardottir, A G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D, Ascher, D B, Blundell, T L, Gherardi, E

    Published in Chemical science (Cambridge) (01-01-2015)
    “…The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential…”
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    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET bindingElectronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c

    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET bindingElectronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c by Sigurdardottir, A. G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D, Ascher, D. B, Blundell, T. L, Gherardi, E

    Published 13-10-2015
    “…The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential…”
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    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding† †Electronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c

    Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding† †Electronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c by Sigurdardottir, A. G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D., Ascher, D. B., Blundell, T. L., Gherardi, E.

    Published in Chemical science (Cambridge) (31-07-2015)
    “…Targeting the lysine-binding pocket of the first kringle domain of HGF/SF using a fragment-based approach identified new chemical entities that can inhibit MET…”
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