Search Results - "Signoret, Nathalie"

New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5 by Tufail, Afzaal, Akkad, Saeed, Noble, Amanda R., Fascione, Martin A., Signoret, Nathalie

“…Chemokines are proteins important for a range of biological processes from cell-directed migration (chemotaxis) to cell activation and differentiation…”
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Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug by Porter, Jack, Noble, Amanda R., Signoret, Nathalie, Fascione, Martin A., Miller, Gavin J.

“…Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer…”
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A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid 'xenoautoantigen' Neu5Gc in humans and the need for a standardised approach to quantification by Hutton, Esme, Scott, Emma, Robson, Craig N, Signoret, Nathalie, Fascione, Martin A

“…Despite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid…”
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Single-molecule and super-resolved imaging deciphers membrane behavior of onco-immunogenic CCR5 by Hunter, Patrick, Payne-Dwyer, Alex L., Shaw, Michael, Signoret, Nathalie, Leake, Mark C.

“…The ability of tumors to establish a pro-tumorigenic microenvironment is an important point of investigation in the search for new therapeutics. Tumors form…”
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Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19 by Wilson, Julie C., Kealy, David, James, Sally R., Plowman, Tobias, Newling, Katherine, Jagger, Christopher, Filbey, Kara, Mann, Elizabeth R., Konkel, Joanne E., Menon, Madhvi, Knight, Sean B., Simpson, Angela, Prihartadi, Aliya, Forshaw, Greg, Todd, Neil, Yates, David R.A., Grainger, John R., Hussell, Tracy, Kaye, Paul M., Signoret, Nathalie, Lagos, Dimitris

“…Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity…”
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Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7 by Phillips, Rebecca, Svensson, Mattias, Aziz, Naveed, Maroof, Asher, Brown, Najmeeyah, Beattie, Lynette, Signoret, Nathalie, Kaye, Paul M

“…Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed…”
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Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent by Signoret, Nathalie, Hewlett, Lindsay, Wavre, Silène, Pelchen-Matthews, Annegret, Oppermann, Martin, Marsh, Mark

“…The signaling activity of several chemokine receptors, including CC chemokine receptor 5 (CCR5), is in part controlled by their internalization, recycling,…”
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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity by Mack, M, Luckow, B, Nelson, P J, Cihak, J, Simmons, G, Clapham, P R, Signoret, N, Marsh, M, Stangassinger, M, Borlat, F, Wells, T N, Schlöndorff, D, Proudfoot, A E

“…CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal…”
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Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis by Kealy, David, Wilson, Julie, Jaconelli, Tom, Hogg, Karen, Coop, Rebecca, Forshaw, Greg, Todd, Neil, Yates, David, Signoret, Nathalie

“…We report on a pilot study exploring whether blood immune signatures can reveal early specific indicator profiles for patients meeting sepsis criteria upon…”
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Mechanisms regulating chemokine receptor activity by Bennett, Laura D., Fox, James M., Signoret, Nathalie

“…Summary Co‐ordinated movement and controlled positioning of leucocytes is key to the development, maintenance and proper functioning of the immune system…”
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Harnessing glycofluoroforms for impedimetric biosensing by Hewson, Alice R, Lloyd-Laney, Henry O, Keenan, Tessa, Richards, Sarah-Jane, Gibson, Matthew I, Linclau, Bruno, Signoret, Nathalie, Fascione, Martin A, Parkin, Alison

“…Glycans play a major role in biological cell-cell recognition and signal transduction but have found limited application in biosensors due to glycan/lectin…”
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Preparation and Application of an Inexpensive α‑Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis by Yates, Nicholas D. J., Warnes, Matthew E., Breetveld, Reuben, Spicer, Christopher D., Signoret, Nathalie, Fascione, Martin

“…α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases and serves as a precursor to pharmaceutically relevant motifs. The…”
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CCR5 susceptibility to ligand‐mediated down‐modulation differs between human T lymphocytes and myeloid cells by Fox, James M., Kasprowicz, Richard, Hartley, Oliver, Signoret, Nathalie

“…The behavior of endogenous CCR5 receptors is influenced by the cellular context on primary human leukocytes. CCR5 is a chemokine receptor expressed on…”
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Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer by Noble, Amanda R, Akkad, Saeed, Yates, Nicholas D J, Jeffries, James M, Signoret, Nathalie, Fascione, Martin A

“…Prostate cancer is the most common cancer in men in the UK with over 50 000 new cases diagnosed each year and although therapeutic advances in surgery,…”
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Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH by Tufail, Afzaal, Akkad, Saeed, Hatton, Natasha E, Yates, Nicholas D. J, Spears, Richard J, Keenan, Tessa, Parkin, Alison, Signoret, Nathalie, Fascione, Martin A

“…Novel methods to construct small molecule-protein bioconjugates are integral to the development of new biomedicines for a variety of diseases. C-C linked…”
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Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients by Ashwin, Helen, Milross, Luke, Wilson, Julie, Majo, Joaquim, Hang Lee, Jimmy Tsz, Calder, Grant, Hunter, Bethany, James, Sally, Lagos, Dimitris, Signoret, Nathalie, Filby, Andrew, Bayraktar, Omer Ali, Fisher, Andrew J, Kaye, Paul M

“…Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with…”
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A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses by Kasprowicz, Richard, Rand, Emma, O’Toole, Peter J., Signoret, Nathalie

“…Cell-to-cell communication engages signaling and spatiotemporal reorganization events driven by highly context-dependent and dynamic intercellular…”
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CD4-Chemokine Receptor Hybrids in Human Immunodeficiency Virus Type 1 Infection by Klasse, P J, Rosenkilde, M M, Signoret, N, Pelchen-Matthews, A, Schwartz, T W, Marsh, M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transduction of Activation Signal That Follows HIV-1 Binding to CD4 and CD4 Dimerization Involves the Immunoglobulin CDR3-like Region in Domain 1 of CD4 by Briant, Laurence, Signoret, Nathalie, Gaubin, Muriel, Robert-Hebmann, Véronique, Zhang, Xin, Murali, Ramachandran, Greene, Mark I., Piatier-Tonneau, Dominique, Devaux, Christian

“…The role of CD4 during the human immunodeficiency virus type 1 (HIV-1) life cycle in T cells is not restricted to binding functions. HIV-1 binding to CD4 also…”
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A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations by Keenan, Tessa, Spears, Richard J, Akkad, Saeed, Mahon, Clare S, Hatton, Natasha E, Walton, Julia, Noble, Amanda, Yates, Nicholas D, Baumann, Christoph G, Parkin, Alison, Signoret, Nathalie, Fascione, Martin A

“…Site-selective chemical methods for protein bioconjugation have revolutionized the fields of cell and chemical biology through the development of novel…”
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