Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 16; no. 3; p. 431
Main Authors:	Garbati, Patrizia, Picco, Cristiana, Magrassi, Raffaella, Signorello, Paolo, Cacopardo, Ludovica, Dalla Serra, Mauro, Faticato, Maria Grazia, De Luca, Maria, Balestra, Francesco, Scavo, Maria Principia, Viti, Federica
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-03-2024 MDPI
Subjects:	Abdomen Cancer therapies Celiac disease colon cancer Colorectal cancer Crohns disease Drug delivery systems Drugs Dysphagia Enzymes Food Gastrointestinal agents Gastrointestinal diseases gut IBD IBS Inflammatory bowel disease Irritable bowel syndrome Large intestine Ligands Mediation Morphology Motility nanocarriers Nanoparticles Protection and preservation Small intestine Sulindac Systematic Review targeted drug delivery Vehicles Honduras colon cancer gut nanocarriers celiac disease targeted drug delivery IBD IBS
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Summary:	The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical-chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics16030431