Search Results - "Signore, Pierre"

A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats by Signore, Pierre E, Guo, Guangjie, Wei, Zhihua, Zhang, Weihua, Lin, Al, del Balzo, Ughetta

“…Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a transcription factor known to regulate erythropoiesis,…”
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Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease by Del Balzo, Ughetta, Signore, Pierre E, Walkinshaw, Gail, Seeley, Todd W, Brenner, Mitchell C, Wang, Qingjian, Guo, Guangjie, Arend, Michael P, Flippin, Lee A, Chow, F Aisha, Gervasi, David C, Kjaergaard, Christian H, Langsetmo, Ingrid, Guenzler, Volkmar, Liu, David Y, Klaus, Steve J, Lin, Al, Neff, Thomas B

“…Anemia of chronic kidney disease (CKD) is a multifactorial disorder caused by impaired erythropoietin (EPO) production and altered iron homeostasis associated…”
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Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction by Vainio, Laura E., MD, Szabó, Zoltán, MSc, Lin, Ruizhu, MSc, Ulvila, Johanna, PhD, Yrjölä, Raisa, MSc, Alakoski, Tarja, MSc, Piuhola, Jarkko, MD, PhD, Koch, Walter J., PhD, Ruskoaho, Heikki, MD, PhD, Fouse, Shaun D., PhD, Seeley, Todd W., PhD, Gao, Erhe, MD, PhD, Signore, Pierre, PhD, Lipson, Kenneth E., PhD, Magga, Johanna, PhD, Kerkelä, Risto, MD, PhD

“…Visual Abstract…”
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FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition by Brenner, Mitchell C., Krzyzanski, Wojciech, Chou, James Z., Signore, Pierre E., Fung, Cyra K., Guzman, David, Li, Dongxia, Zhang, Weihua, Olsen, David R., Nguyen, Viet-Tam L., Koo, Carolyn W., Sternlicht, Mark D., Lipson, Kenneth E.

“…Purpose To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue…”
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Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload-Induced Heart Failure by SZABO, Zoltán, MAGGA, Johanna, SIGNORE, Pierre, KERKELÄ, Risto, ALAKOSKI, Tarja, ULVILA, Johanna, PIUHOLA, Jarkko, VAINIO, Laura, KIVIRIKKO, Kari I, VUOLTEENAHO, Olli, RUSKOAHO, Heikki, LIPSON, Kenneth E

“…Connective tissue growth factor (CTGF) is involved in the pathogenesis of various fibrotic disorders. However, its role in the heart is not clear. To…”
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Effect of pharmacological blockade on cardiovascular responses to voluntary and forced diving in muskrats by Signore, P E, Jones, D R

“…Neural control of free and forced diving bradycardia and peripheral resistance was studied in the muskrat (Ondatra zibethicus) by means of acute…”
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Autonomic nervous control of heart rate in muskrats during exercise in air and under water by Signore, P E, Jones, D R

“…Neural control of the cardiac responses to exercise in air (running) and under water (diving) was studied in the muskrat (Ondatra zibethicus) by means of acute…”
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Abstract 16852: Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Reduces Infarct Size and Improves Cardiac Function in a Rat Model of Myocardial Ischemia Reperfusion Injury by Signore, Pierre, Wei, Zhihua, Fung, Cyra, Russell, Loren, Arend, Michael, Flippin, Lee, Walkinshaw, Gail, del Balzo, Ughetta

“…Abstract only Hypoxia-inducible factor (HIF) has been shown to have cardioprotective effects when stabilized prior to a cardiac ischemic event. In the present…”
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Characterization of perivascular poly(lactic-co-glycolic acid) films containing paclitaxel by Jackson, John K., Smith, Janet, Letchford, Kevin, Babiuk, Kelly Anne, Machan, Lindsay, Signore, Pierre, Hunter, William L., Wang, Kaiyue, Burt, Helen M.

“…The objectives of this study were to investigate the use of poly(lactic-co-glycolic acid) (PLGA) for the formulation of paclitaxel loaded films and to…”
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A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats by Pierre E. Signore, Guangjie Guo, Zhihua Wei, Weihua Zhang, Al Lin, Ughetta del Balzo

“…Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a transcription factor known to regulate erythropoiesis,…”
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Complete inhibition of intimal hyperplasia by perivascular delivery of paclitaxel in balloon-injured rat carotid arteries by Signore, P E, Machan, L S, Jackson, J K, Burt, H, Bromley, P, Wilson, J E, McManus, B M

“…To determine whether perivascular delivery of paclitaxel prevents luminal narrowing after balloon injury by inhibiting intimal hyperplasia. Immediately after…”
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An assessment of handedness in mice by Signore, P, Nosten-Bertrand, M, Chaoui, M, Roubertoux, P L, Marchaland, C, Perez-Diaz, F

“…Mice from a pool of inbred strains (384 males and 329 females) were tested for handedness according to Collins' protocol in order to assess the reliability of…”
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Paw preference and intra-/infrapyramidal mossy fibers in the hippocampus of the mouse by Lipp, H P, Collins, R L, Hausheer-Zarmakupi, Z, Leisinger-Trigona, M C, Crusio, W E, Nosten-Bertrand, M, Signore, P, Schwegler, H, Wolfer, D P

“…The size of the intra-/infrapyramidal mossy fiber projections (IIP-MF) and their left/right asymmetry were assessed in 86 mice of either sex, including 26…”
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Handedness in mice : comparison across eleven inbred strains by SIGNORE, P, MOHAMED CHAOUI, NOSTEN-BERTRAND, M, PEREZ-DIAZ, F, MARCHALAND, C

“…Screening for handedness was performed in 11 inbred strains of mice. Direction and degree of handedness were measured for both males and females in each…”
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