Search Results - "Sigmund, Rita D"

Discordant effects of corticosteroids and expression of subunits on ENaC activity by Husted, Russell F, Volk, Kenneth A, Sigmund, Rita D, Stokes, John B

“…In renal distal nephron and airway epithelial cells, adrenocortical steroids increase epithelial Na+ channel (ENaC) activity and also markedly increase the…”
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Regulation of rENaC mRNA by dietary NaCl and steroids: organ, tissue, and steroid heterogeneity by Stokes, J.B, Sigmund, R.D

“…Rats on a low-NaCl diet have a high Na+ channel activity in colon and kidney. To address the mechanism of this increased activity, we measured mRNA levels of…”
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Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medulla by Stein, Colleen S, Yancey, Paul H, Martins, Inês, Sigmund, Rita D, Stokes, John B, Davidson, Beverly L

“…Recessive inheritance of mutations in ceroid neuronal lipofuscinosis type 3 (CLN3) results in juvenile neuronal ceroid lipofuscinosis (JNCL), a childhood…”
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Oxygen regulation of the epithelial Na channel in the collecting duct by Husted, Russell F, Lu, Hongyan, Sigmund, Rita D, Stokes, John B

“…The PO(2) within the kidney changes dramatically from cortex to medulla. The present experiments examined the effect of changing PO(2) on epithelial Na channel…”
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Amiloride-sensitive Na+ channels in pelvic uroepithelium involved in renal sensory receptor activation by Kopp, U C, Matsushita, K, Sigmund, R D, Smith, L A, Watanabe, S, Stokes, J B

“…Stretching the renal pelvic wall increases ipsilateral afferent renal nerve activity (ARNA). This response is enhanced by inhibiting Na+-K+-ATPase with…”
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Overexpression of the epithelial Na+ channel gamma subunit in collecting duct cells: interactions of Liddle's mutations and steroids on expression and function by Volk, Kenneth A, Husted, Russell F, Sigmund, Rita D, Stokes, John B

“…The epithelial Na(+) channel (ENaC) has three subunits; the expression of each can be regulated. Liddle's syndrome is caused by an activating mutation in the C…”
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Mice heterozygous for beta-ENaC deletion have defective potassium excretion by Cao, X Renee, Shi, P Peter, Sigmund, Rita D, Husted, Russell F, Sigmund, Curt D, Williamson, Roger A, Stokes, John B, Yang, Baoli

“…The present studies were designed to determine whether mice heterozygous for deletion of beta-ENaC exhibited defects in Na+/K+ transport and blood pressure…”
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Mechanisms of inactivation of the action of aldosterone on collecting duct by TGF-beta by Husted, R F, Sigmund, R D, Stokes, J B

“…The purpose of these experiments was to investigate the mechanisms whereby transforming growth factor-beta (TGF-beta) antagonizes the action of adrenocorticoid…”
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DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells by Woynarowski, Jan M, Sigmund, Rita D, Beerman, Terry A

“…This study demonstrated that agents capable of interacting with the minor groove in nuclear DNA interfere with topoisomerase II mediated effects of antitumor…”
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Genetic Characterization of the 'New' Harlan Sprague Dawley Dahl Salt-Sensitive Rats by Walder, Roxanne Y, Morgan, Donald A, Haynes, William G, Sigmund, Rita D, McClain, Ann M, Stokes, John B, Mark, Allyn L

“…In 1994, it was reported that Dahl salt-sensitive SS/Jr rats supplied by Harlan Sprague Dawley were genetically contaminated and resistant to the pressor…”
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Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in murine cells by deoxyribonuclease I, bleomycin, neocarzinostatin, or ionizing radiation by Beckmann, Richard P, Agostino, Michael J, McHugh, Mary M, Sigmund, Rita D, Beerman, Terry A

“…Preferential cleavage induced by bleomycin, neocarzinostatin, or ionizing radiation in a transcribed cellular gene was evaluated through comparisons with…”
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Overexpression of the Epithelial Na+ Channel γ Subunit in Collecting Duct Cells by Volk, Kenneth A., Husted, Russell F., Sigmund, Rita D., Stokes, John B.

“…The epithelial Na+ channel (ENaC) has three subunits; the expression of each can be regulated. Liddle's syndrome is caused by an activating mutation in the C…”
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Overexpression of the Epithelial Na super(+) Channel gamma Subunit in Collecting Duct Cells: Interactions of Liddle's Mutations and Steriods on Expression and Function by Volk, Kenneth A, Husted, Russell F, Sigmund, Rita D, Stokes, John B

“…The epithelial Na super(+) channel (ENaC) has three subunits; the expression of each can be regulated. Liddle's syndrome is caused by an activating mutation in…”
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Overexpression of the Epithelial Na+ Channel γ Subunit in Collecting Duct Cells by Kenneth A. Volk, Russell F. Husted, Rita D. Sigmund, John B. Stokes

“…The epithelial Na + channel (ENaC) has three subunits; the expression of each can be regulated. Liddle's syndrome is caused by an activating mutation in the C…”
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Anion secretion by the inner medullary collecting duct. Evidence for involvement of the cystic fibrosis transmembrane conductance regulator by Husted, R F, Volk, K A, Sigmund, R D, Stokes, J B

“…It is well established that the terminal renal collecting duct is capable of electrogenic Na+ absorption. The present experiments examined other active ion…”
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rENaC is the predominant Na+ channel in the apical membrane of the rat renal inner medullary collecting duct by Volk, K A, Sigmund, R D, Snyder, P M, McDonald, F J, Welsh, M J, Stokes, J B

“…The terminal nephron segment, the inner medullary collecting duct (IMCD), absorbs Na+ by an electrogenic process that involves the entry through an apical…”
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Effect of minor groove binding drugs on mammalian topoisomerase I activity by McHugh, M M, Woynarowski, J M, Sigmund, R D, Beerman, T A

“…Three minor groove binding drugs, distamycin A, bisbenzimide (Hoechst 33258) and 4',6-diamidino-2-phenylindole (DAPI), were examined for their abilities to…”
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Effects of minor groove binding drugs on camptothecin-induced DNA lesions in L1210 nuclei by McHugh, M M, Sigmund, R D, Beerman, T A

“…Topoisomerase I inhibition detected in mammalian cells can be correlated with reduced tumor growth. Camptothecin specifically inhibits topoisomerase I by…”
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Neurospora glucamylase and a mutant affected in its regulation by SIGMUND, R. D, MCNALLY, M. T, LEE, D. B, FREE, S. J

“…Neurospora glucamylase is a glucose-repressible extracellular enzyme. The enzyme was purified to homogeneity and found to have a molecular weight of 82,000 and…”
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