Search Results - "Sigman, Matthew S"

Holistic prediction of enantioselectivity in asymmetric catalysis by Reid, Jolene P., Sigman, Matthew S.

“…When faced with unfamiliar reaction space, synthetic chemists typically apply the reported conditions (reagents, catalyst, solvent and additives) of a…”
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Enantioselective construction of remote quaternary stereocentres by Mei, Tian-Sheng, Patel, Harshkumar H., Sigman, Matthew S.

“…Small molecules that contain all-carbon quaternary stereocentres—carbon atoms bonded to four distinct carbon substituents—are found in many secondary…”
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Predictive and mechanistic multivariate linear regression models for reaction development by Santiago, Celine B, Guo, Jing-Yao, Sigman, Matthew S

“…Multivariate Linear Regression (MLR) models utilizing computationally-derived and empirically-derived physical organic molecular descriptors are described in…”
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Applications of ortho-Quinone Methide Intermediates in Catalysis and Asymmetric Synthesis by Pathak, Tejas P, Sigman, Matthew S

“…Ortho-quinone methides are important synthetic intermediates and widely implicated in biological processes. In this Synopsis, recent advances concerning the…”
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A synthetic chemist's guide to electroanalytical tools for studying reaction mechanisms by Sandford, Christopher, Edwards, Martin A, Klunder, Kevin J, Hickey, David P, Li, Min, Barman, Koushik, Sigman, Matthew S, White, Henry S, Minteer, Shelley D

“…Monitoring reactive intermediates can provide vital information in the study of synthetic reaction mechanisms, enabling the design of new catalysts and…”
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Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners by Jana, Ranjan, Pathak, Tejas P, Sigman, Matthew S

“…Ranjan et al discuss recent research in transition metal catalyzed cross-coupling reactions. The use of alkyl-organometallics as reaction partners is also…”
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Palladium-catalyzed enantioselective Heck alkenylation of acyclic alkenols using a redox-relay strategy by Patel, Harshkumar H, Sigman, Matthew S

“…We report a highly enantioselective intermolecular Heck reaction of alkenyl triflates and acyclic primary or racemic secondary alkenols. The mild reaction…”
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Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols To Form Allylic Quaternary Centers by Patel, Harshkumar H, Sigman, Matthew S

“…In this report, we describe the generation of remote allylic quaternary stereocenters β, γ, and δ relative to a carbonyl in high enantioselectivity. We utilize…”
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Integrating Electrochemical and Statistical Analysis Tools for Molecular Design and Mechanistic Understanding by Robinson, Sophia G, Sigman, Matthew S

“…Conspectus Medicinal chemistry campaigns set the foundation for streamlined molecular design strategies through the development of quantitative…”
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Enantioselective construction of remote tertiary carbon–fluorine bonds by Liu, Jianbo, Yuan, Qianjia, Toste, F. Dean, Sigman, Matthew S.

“…The carbon–fluorine bond engenders distinctive physicochemical properties and significant changes to general reactivity. The development of catalytic,…”
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Univariate classification of phosphine ligation state and reactivity in cross-coupling catalysis by Newman-Stonebraker, Samuel H, Smith, Sleight R, Borowski, Julia E, Peters, Ellyn, Gensch, Tobias, Johnson, Heather C, Sigman, Matthew S, Doyle, Abigail G

“…Chemists often use statistical analysis of reaction data with molecular descriptors to identify structure-reactivity relationships, which can enable prediction…”
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Imparting Catalyst Control upon Classical Palladium-Catalyzed Alkenyl C–H Bond Functionalization Reactions by Sigman, Matthew S, Werner, Erik W

“…The functional group transformations carried out by the palladium-catalyzed Wacker and Heck reactions are radically different, but they are both alkenyl C–H…”
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Data Science Meets Physical Organic Chemistry by Crawford, Jennifer M, Kingston, Cian, Toste, F. Dean, Sigman, Matthew S

“…Conspectus At the heart of synthetic chemistry is the holy grail of predictable catalyst design. In particular, researchers involved in reaction development in…”
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Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy by Werner, Erik W., Mei, Tian-Sheng, Burckle, Alexander J., Sigman, Matthew S.

“…Progress in the development of asymmetric Heck couplings of arenes and acyclic olefins has been limited by a tenuous understanding of the factors that dictate…”
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Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes by Niemeyer, Zachary L., Milo, Anat, Hickey, David P., Sigman, Matthew S.

“…The mechanistic foundation behind the identity of a phosphine ligand that best promotes a desired reaction outcome is often non-intuitive, and thus has been…”
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Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines by Woods, Brian P, Orlandi, Manuel, Huang, Chung-Yang, Sigman, Matthew S, Doyle, Abigail G

“…A Ni-catalyzed reductive cross-coupling of styrenyl aziridines with aryl iodides is reported. This reaction proceeds by a stereoconvergent mechanism and is…”
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Three-Dimensional Correlation of Steric and Electronic Free Energy Relationships Guides Asymmetric Propargylation by Harper, Kaid C., Sigman, Matthew S.

“…Chemical reaction outcomes are often rationalized on the basis of independent analyses of steric and electronic effects. We applied three-dimensional free…”
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Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization by Zhao, Shibin, Gensch, Tobias, Murray, Benjamin, Niemeyer, Zachary L, Sigman, Matthew S, Biscoe, Mark R

“…Despite the enormous potential for the use of stereospecific cross-coupling reactions to rationally manipulate the three-dimensional structure of organic…”
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Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols by Chen, Zhi-Min, Hilton, Margaret J, Sigman, Matthew S

“…An enantio­selective redox-relay oxidative Heck arylation of 1,1-disubstituted alkenes to construct β-stereo­centers was developed using a new…”
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Synthesis of Highly Functionalized Tri- and Tetrasubstituted Alkenes via Pd-Catalyzed 1,2-Hydrovinylation of Terminal 1,3-Dienes by Saini, Vaneet, O’Dair, Mark, Sigman, Matthew S

“…An efficient method for the construction of Csp2–Csp3 bond in a regio- and stereoselective fashion involving 1,3-terminal dienes, enol triflates/nonaflates,…”
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